Eighty patients with symptomatic drug-resistant temporal epilepsy aged 2–17 years were operated on from 2011 to 2016, the factors that influenced the outcome of surgical treatment were studied. Favorable prognostic factors for the effectiveness of surgical treatment in the long-term period were: male sex (p<0.01), children older than seven years (p<0.01), disease duration less than three years (p<0.05), intake of fewer than three anticonvulsants drugs (p<0.01), no history of febrile seizures and epileptic reactions (p<0.05), no comorbid conditions (p<0.05), serial seizures and statuses (p<0.01), no early postoperative seizures (p<0.01). The most effective were left-sided resections (p<0.05), lesionectomy (p<0.05) with removal of epileptogenic foci (p<0.01). Thus, rational tactics for surgical treatment of drug-resistant temporal epilepsy in children should be carried out by taking into account the age-related characteristics of the child’s development, the nature of the intercurrent pathology, as well as the alleged etiological factor, taking into account the peculiarity of the course of the pathological process.