Results are presented on hyperon and antihyperon production in Pb-Pb, pPb and pBe collisions at 158 GeV/c per nucleon. Λ, Ξ and Ω yields have been measured at central rapidity and medium transverse momentum as functions of the centrality of the collision. Comparing the yields in Pb-Pb to those in pBe interactions, strangeness enhancement is observed. The enhancement increases with the centrality and with the strangeness content of the hyperons, reaching a factor of about 20 for the Ω in the central Pb-Pb collisions.