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Endogenous retrovirus insertion in the KIT oncogene determines white and white spotting in domestic cats. / David, V.A.; Menotti-Raymond, M.; Wallace, A.C.; Roelke, M.; Kehler, J.; Leighty, R.; Eizirik, E.; Hannah, S.S.; Nelson, G.; Schäffer, A.A.; Connelly, C.J.; O'Brien, S.J.; Ryugo, D.K.

In: G3 (Bethesda, Md.), No. 10, 2014, p. 1881-1891.

Research output: Contribution to journal › Article

Harvard

David, VA, Menotti-Raymond, M, Wallace, AC, Roelke, M, Kehler, J, Leighty, R, Eizirik, E, Hannah, SS, Nelson, G, Schäffer, AA, Connelly, CJ, O'Brien, SJ & Ryugo, DK 2014, 'Endogenous retrovirus insertion in the KIT oncogene determines white and white spotting in domestic cats', G3 (Bethesda, Md.), no. 10, pp. 1881-1891. https://doi.org/10.1534/g3.114.013425

APA

David, V. A., Menotti-Raymond, M., Wallace, A. C., Roelke, M., Kehler, J., Leighty, R., Eizirik, E., Hannah, S. S., Nelson, G., Schäffer, A. A., Connelly, C. J., O'Brien, S. J., & Ryugo, D. K. (2014). Endogenous retrovirus insertion in the KIT oncogene determines white and white spotting in domestic cats. G3 (Bethesda, Md.), (10), 1881-1891. https://doi.org/10.1534/g3.114.013425

Vancouver

David VA, Menotti-Raymond M, Wallace AC, Roelke M, Kehler J, Leighty R et al. Endogenous retrovirus insertion in the KIT oncogene determines white and white spotting in domestic cats. G3 (Bethesda, Md.). 2014;(10):1881-1891. https://doi.org/10.1534/g3.114.013425

Author

David, V.A. ; Menotti-Raymond, M. ; Wallace, A.C. ; Roelke, M. ; Kehler, J. ; Leighty, R. ; Eizirik, E. ; Hannah, S.S. ; Nelson, G. ; Schäffer, A.A. ; Connelly, C.J. ; O'Brien, S.J. ; Ryugo, D.K. / Endogenous retrovirus insertion in the KIT oncogene determines white and white spotting in domestic cats. In: G3 (Bethesda, Md.). 2014 ; No. 10. pp. 1881-1891.

BibTeX

@article{1f814d3f121e494189ab69ade3a448ff,
title = "Endogenous retrovirus insertion in the KIT oncogene determines white and white spotting in domestic cats",
abstract = "Copyright {\textcopyright} 2014 David et al. The Dominant White locus (W) in the domestic cat demonstrates pleiotropic effects exhibiting complete penetrance for absence of coat pigmentation and incomplete penetrance for deafness and iris hypopigmentation. We performed linkage analysis using a pedigree segregating White to identify KIT (Chr. B1) as the feline W locus. Segregation and sequence analysis of the KIT gene in two pedigrees (P1 and P2) revealed the remarkable retrotransposition and evolution of a feline endogenous retrovirus (FERV1) as responsible for two distinct phenotypes of the W locus, Dominant White, and white spotting. A full-length (7125 bp) FERV1 element is associated with white spotting, whereas a FERV1 long terminal repeat (LTR) is associated with all Dominant White individuals. For purposes of statistical analysis, the alternatives of wild-type sequence, FERV1 element, and LTR-only define a triallelic marker. Taking into account pedigree relationships, deafness is genetically linked and associated with",
author = "V.A. David and M. Menotti-Raymond and A.C. Wallace and M. Roelke and J. Kehler and R. Leighty and E. Eizirik and S.S. Hannah and G. Nelson and A.A. Sch{\"a}ffer and C.J. Connelly and S.J. O'Brien and D.K. Ryugo",
year = "2014",
doi = "10.1534/g3.114.013425",
language = "English",
pages = "1881--1891",
journal = "G3: Genes, Genomes, Genetics",
issn = "2160-1836",
publisher = "Genetics Society of America",
number = "10",

}

RIS

TY - JOUR

T1 - Endogenous retrovirus insertion in the KIT oncogene determines white and white spotting in domestic cats

AU - David, V.A.

AU - Menotti-Raymond, M.

AU - Wallace, A.C.

AU - Roelke, M.

AU - Kehler, J.

AU - Leighty, R.

AU - Eizirik, E.

AU - Hannah, S.S.

AU - Nelson, G.

AU - Schäffer, A.A.

AU - Connelly, C.J.

AU - O'Brien, S.J.

AU - Ryugo, D.K.

PY - 2014

Y1 - 2014

N2 - Copyright © 2014 David et al. The Dominant White locus (W) in the domestic cat demonstrates pleiotropic effects exhibiting complete penetrance for absence of coat pigmentation and incomplete penetrance for deafness and iris hypopigmentation. We performed linkage analysis using a pedigree segregating White to identify KIT (Chr. B1) as the feline W locus. Segregation and sequence analysis of the KIT gene in two pedigrees (P1 and P2) revealed the remarkable retrotransposition and evolution of a feline endogenous retrovirus (FERV1) as responsible for two distinct phenotypes of the W locus, Dominant White, and white spotting. A full-length (7125 bp) FERV1 element is associated with white spotting, whereas a FERV1 long terminal repeat (LTR) is associated with all Dominant White individuals. For purposes of statistical analysis, the alternatives of wild-type sequence, FERV1 element, and LTR-only define a triallelic marker. Taking into account pedigree relationships, deafness is genetically linked and associated with

AB - Copyright © 2014 David et al. The Dominant White locus (W) in the domestic cat demonstrates pleiotropic effects exhibiting complete penetrance for absence of coat pigmentation and incomplete penetrance for deafness and iris hypopigmentation. We performed linkage analysis using a pedigree segregating White to identify KIT (Chr. B1) as the feline W locus. Segregation and sequence analysis of the KIT gene in two pedigrees (P1 and P2) revealed the remarkable retrotransposition and evolution of a feline endogenous retrovirus (FERV1) as responsible for two distinct phenotypes of the W locus, Dominant White, and white spotting. A full-length (7125 bp) FERV1 element is associated with white spotting, whereas a FERV1 long terminal repeat (LTR) is associated with all Dominant White individuals. For purposes of statistical analysis, the alternatives of wild-type sequence, FERV1 element, and LTR-only define a triallelic marker. Taking into account pedigree relationships, deafness is genetically linked and associated with

U2 - 10.1534/g3.114.013425

DO - 10.1534/g3.114.013425

M3 - Article

SP - 1881

EP - 1891

JO - G3: Genes, Genomes, Genetics

JF - G3: Genes, Genomes, Genetics

SN - 2160-1836

IS - 10

ER -

ID: 7065897