Research output: Contribution to journal › Article › peer-review
Electrophysiological and behavioral markers of hyperdopaminergia in DAT-KO rats. / Фесенко, Зоя Сергеевна; Птуха, Мария Александровна; da Silva, Marcelo M ; de Carvalho, Raquel S. Marques ; Цыцарев, Василий ; Гайнетдинов, Рауль Радикович; Faber, Jean; Вольнова, Анна Борисовна.
In: Biomedicines, Vol. 12, No. 9, 17.09.2024.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Electrophysiological and behavioral markers of hyperdopaminergia in DAT-KO rats
AU - Фесенко, Зоя Сергеевна
AU - Птуха, Мария Александровна
AU - da Silva, Marcelo M
AU - de Carvalho, Raquel S. Marques
AU - Цыцарев, Василий
AU - Гайнетдинов, Рауль Радикович
AU - Faber, Jean
AU - Вольнова, Анна Борисовна
PY - 2024/9/17
Y1 - 2024/9/17
N2 - Background/Objectives: Dopamine dysfunction (DA) is a hallmark of many neurological disorders. In this case, the mechanism of changes in dopamine transmission on behavior remains unclear. This study is a look into the intricate link between disrupted DA signaling, neuronal activity patterns, and behavioral abnormalities in a hyperdopaminergic animal model. Methods: To study the relationship between altered DA levels, neuronal activity, and behavioral deficits, local field potentials (LFPs) were recorded during four different behaviors in dopamine transporter knockout rats (DAT-KO). At the same time, local field potentials were recorded in the striatum and prefrontal cortex. Correlates of LFP and accompanying behavioral patterns in genetically modified (DAT-KO) and control animals were studied. Results: DAT-KO rats exhibited desynchronization between LFPs of the striatum and prefrontal cortex, particularly during exploratory behavior. A suppressive effect of high dopamine levels on the striatum was also observed. Wild-type rats showed greater variability in LFP patterns across certain behaviors, while DAT-KO rats showed more uniform patterns. Conclusions: The decisive role of the synchrony of STR and PFC neurons in the organization of motor acts has been revealed. The greater variability of control animals in certain forms of behavior probably suggests greater adaptability. More uniform patterns in DAT-KO rats, indicating a loss of striatal flexibility when adapting to specific motor tasks. It is likely that hyperdopaminergy in the DAT-KO rat reduces the efficiency of information processing due to less synchronized activity during active behavior.
AB - Background/Objectives: Dopamine dysfunction (DA) is a hallmark of many neurological disorders. In this case, the mechanism of changes in dopamine transmission on behavior remains unclear. This study is a look into the intricate link between disrupted DA signaling, neuronal activity patterns, and behavioral abnormalities in a hyperdopaminergic animal model. Methods: To study the relationship between altered DA levels, neuronal activity, and behavioral deficits, local field potentials (LFPs) were recorded during four different behaviors in dopamine transporter knockout rats (DAT-KO). At the same time, local field potentials were recorded in the striatum and prefrontal cortex. Correlates of LFP and accompanying behavioral patterns in genetically modified (DAT-KO) and control animals were studied. Results: DAT-KO rats exhibited desynchronization between LFPs of the striatum and prefrontal cortex, particularly during exploratory behavior. A suppressive effect of high dopamine levels on the striatum was also observed. Wild-type rats showed greater variability in LFP patterns across certain behaviors, while DAT-KO rats showed more uniform patterns. Conclusions: The decisive role of the synchrony of STR and PFC neurons in the organization of motor acts has been revealed. The greater variability of control animals in certain forms of behavior probably suggests greater adaptability. More uniform patterns in DAT-KO rats, indicating a loss of striatal flexibility when adapting to specific motor tasks. It is likely that hyperdopaminergy in the DAT-KO rat reduces the efficiency of information processing due to less synchronized activity during active behavior.
KW - DAT-KO rats
KW - behavior
KW - dopamine
KW - dopamine transporter (DAT)
KW - hyperdopaminergia
KW - local field potential (LFP)
UR - https://www.mendeley.com/catalogue/fc405b06-ed8d-3432-a301-66796259c8ab/
U2 - https://doi.org/10.3390/biomedicines12092114
DO - https://doi.org/10.3390/biomedicines12092114
M3 - Article
C2 - 39335627
VL - 12
JO - Biomedicines
JF - Biomedicines
SN - 2227-9059
IS - 9
ER -
ID: 124534759