Efficient synthesis of novel fluorinated phenanthridin-6(5H)-one derivatives and in vitro evaluation of their antiviral activity

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Efficient synthesis of novel fluorinated phenanthridin-6(5H)-one derivatives and in vitro evaluation of their antiviral activity. / Gurskaya, Larisa; Politanskaya, Larisa; Wang, Jiaying; Ilyina, Polina; Volobueva, Alexandrina; Zarubaev, Vladimir.

In: Journal of Fluorine Chemistry, Vol. 274, 110240, 01.02.2024.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{c854ea79a695441c8dfd7cd9e0ea9799,

title = "Efficient synthesis of novel fluorinated phenanthridin-6(5H)-one derivatives and in vitro evaluation of their antiviral activity",

abstract = "A convenient and efficient method for the synthesis of fluorinated phenanthridin-6(5H)-ones from the corresponding 2-isocyanato-1,1′-biphenyls mediated by trifluoromethanesulfonic acid in chlorobenzene is described. The reaction uses readily available starting materials, takes place under very mild reaction conditions (r. t.) and provides access to biologically promising fluorinated heterocycles in good to excellent yields. Synthesized compounds were tested in vitro for cytotoxicity in MDCK cell line and for antiviral activity against influenza virus A/Puerto Rico/8/34 (H1N1).",

keywords = "Aryl isocyanates, Fluorinated 2-amino-1,1′-biphenyls, Influenza virus, Trifluoromethanesulfonic acid",

author = "Larisa Gurskaya and Larisa Politanskaya and Jiaying Wang and Polina Ilyina and Alexandrina Volobueva and Vladimir Zarubaev",

year = "2024",

month = feb,

day = "1",

doi = "10.1016/j.jfluchem.2024.110240",

language = "English",

volume = "274",

journal = "Journal of Fluorine Chemistry",

issn = "0022-1139",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Efficient synthesis of novel fluorinated phenanthridin-6(5H)-one derivatives and in vitro evaluation of their antiviral activity

AU - Gurskaya, Larisa

AU - Politanskaya, Larisa

AU - Wang, Jiaying

AU - Ilyina, Polina

AU - Volobueva, Alexandrina

AU - Zarubaev, Vladimir

PY - 2024/2/1

Y1 - 2024/2/1

N2 - A convenient and efficient method for the synthesis of fluorinated phenanthridin-6(5H)-ones from the corresponding 2-isocyanato-1,1′-biphenyls mediated by trifluoromethanesulfonic acid in chlorobenzene is described. The reaction uses readily available starting materials, takes place under very mild reaction conditions (r. t.) and provides access to biologically promising fluorinated heterocycles in good to excellent yields. Synthesized compounds were tested in vitro for cytotoxicity in MDCK cell line and for antiviral activity against influenza virus A/Puerto Rico/8/34 (H1N1).

AB - A convenient and efficient method for the synthesis of fluorinated phenanthridin-6(5H)-ones from the corresponding 2-isocyanato-1,1′-biphenyls mediated by trifluoromethanesulfonic acid in chlorobenzene is described. The reaction uses readily available starting materials, takes place under very mild reaction conditions (r. t.) and provides access to biologically promising fluorinated heterocycles in good to excellent yields. Synthesized compounds were tested in vitro for cytotoxicity in MDCK cell line and for antiviral activity against influenza virus A/Puerto Rico/8/34 (H1N1).

KW - Aryl isocyanates

KW - Fluorinated 2-amino-1,1′-biphenyls

KW - Influenza virus

KW - Trifluoromethanesulfonic acid

UR - https://www.mendeley.com/catalogue/fc05c80e-98d5-32c9-86cd-84da3c9bda98/

U2 - 10.1016/j.jfluchem.2024.110240

DO - 10.1016/j.jfluchem.2024.110240

M3 - Article

VL - 274

JO - Journal of Fluorine Chemistry

JF - Journal of Fluorine Chemistry

SN - 0022-1139

M1 - 110240

ER -

ID: 123930066