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Efficient labeling of organic molecules using 13C elemental carbon: universal access to 13С2-labeled synthetic building blocks, polymers and pharmaceuticals. / Ledovskaya, Maria S. ; Voronin, Vladimir V.; Rodygin, Konstantin S. ; Ananikov, Valentine P. ч.

In: Organic Chemistry Frontiers, Vol. 7, No. 4, 2020, p. 638-647.

Research output: Contribution to journal › Article › peer-review

Harvard

Ledovskaya, MS, Voronin, VV, Rodygin, KS & Ananikov, VPЧ 2020, 'Efficient labeling of organic molecules using 13C elemental carbon: universal access to 13С2-labeled synthetic building blocks, polymers and pharmaceuticals', Organic Chemistry Frontiers, vol. 7, no. 4, pp. 638-647.

APA

Ledovskaya, M. S., Voronin, V. V., Rodygin, K. S., & Ananikov, V. P. Ч. (2020). Efficient labeling of organic molecules using 13C elemental carbon: universal access to 13С2-labeled synthetic building blocks, polymers and pharmaceuticals. Organic Chemistry Frontiers, 7(4), 638-647.

Vancouver

Ledovskaya MS, Voronin VV, Rodygin KS, Ananikov VPЧ. Efficient labeling of organic molecules using 13C elemental carbon: universal access to 13С2-labeled synthetic building blocks, polymers and pharmaceuticals. Organic Chemistry Frontiers. 2020;7(4):638-647.

Author

Ledovskaya, Maria S. ; Voronin, Vladimir V. ; Rodygin, Konstantin S. ; Ananikov, Valentine P. ч. / Efficient labeling of organic molecules using 13C elemental carbon: universal access to 13С2-labeled synthetic building blocks, polymers and pharmaceuticals. In: Organic Chemistry Frontiers. 2020 ; Vol. 7, No. 4. pp. 638-647.

BibTeX

@article{6b6fb11a0cd942928e91d7847239ed13,
title = "Efficient labeling of organic molecules using 13C elemental carbon: universal access to 13С2-labeled synthetic building blocks, polymers and pharmaceuticals",
abstract = "Among different types of labeling, 13C-labeled compounds are the most demanding in organic chemistry, life sciences and materials design. However, 13C-labeled organic molecules are very difficult to employ in practice due to extreme cost. The rather narrow range of labeled organic starting materials and the absence of universal synthetic building units further complicate the problem and make utilization of 13C-labeled molecules hardly possible in many cases. Here we report a versatile approach for 13C2-labeling of organic molecules starting with 13C elemental carbon: 13C carbon is applied for the synthesis of calcium carbide (Ca13C2), which is subsequently used to generate acetylene – a universal 13C2 unit for atom-economic organic transformations. Syntheses of labeled alkynes, O,S,N-functionalized vinyl derivatives, polymers and pharmaceutical substances were demonstrated. Elemental 13C carbon, as the chemically most simple source for 13C2-labeling, here was successfully combined with universal synthetic applicability of alkynes.",
author = "Ledovskaya, {Maria S.} and Voronin, {Vladimir V.} and Rodygin, {Konstantin S.} and Ananikov, {Valentine P. ч}",
note = "Org. Chem. Front., 2020,7, 638-647",
year = "2020",
language = "English",
volume = "7",
pages = "638--647",
journal = "Organic Chemistry Frontiers",
issn = "2052-4110",
publisher = "Royal Society of Chemistry",
number = "4",

}

RIS

TY - JOUR

T1 - Efficient labeling of organic molecules using 13C elemental carbon: universal access to 13С2-labeled synthetic building blocks, polymers and pharmaceuticals

AU - Ledovskaya, Maria S.

AU - Voronin, Vladimir V.

AU - Rodygin, Konstantin S.

AU - Ananikov, Valentine P. ч

N1 - Org. Chem. Front., 2020,7, 638-647

PY - 2020

Y1 - 2020

N2 - Among different types of labeling, 13C-labeled compounds are the most demanding in organic chemistry, life sciences and materials design. However, 13C-labeled organic molecules are very difficult to employ in practice due to extreme cost. The rather narrow range of labeled organic starting materials and the absence of universal synthetic building units further complicate the problem and make utilization of 13C-labeled molecules hardly possible in many cases. Here we report a versatile approach for 13C2-labeling of organic molecules starting with 13C elemental carbon: 13C carbon is applied for the synthesis of calcium carbide (Ca13C2), which is subsequently used to generate acetylene – a universal 13C2 unit for atom-economic organic transformations. Syntheses of labeled alkynes, O,S,N-functionalized vinyl derivatives, polymers and pharmaceutical substances were demonstrated. Elemental 13C carbon, as the chemically most simple source for 13C2-labeling, here was successfully combined with universal synthetic applicability of alkynes.

AB - Among different types of labeling, 13C-labeled compounds are the most demanding in organic chemistry, life sciences and materials design. However, 13C-labeled organic molecules are very difficult to employ in practice due to extreme cost. The rather narrow range of labeled organic starting materials and the absence of universal synthetic building units further complicate the problem and make utilization of 13C-labeled molecules hardly possible in many cases. Here we report a versatile approach for 13C2-labeling of organic molecules starting with 13C elemental carbon: 13C carbon is applied for the synthesis of calcium carbide (Ca13C2), which is subsequently used to generate acetylene – a universal 13C2 unit for atom-economic organic transformations. Syntheses of labeled alkynes, O,S,N-functionalized vinyl derivatives, polymers and pharmaceutical substances were demonstrated. Elemental 13C carbon, as the chemically most simple source for 13C2-labeling, here was successfully combined with universal synthetic applicability of alkynes.

UR - https://pubs.rsc.org/en/content/articlelanding/2020/qo/c9qo01357a#!divAbstract

M3 - Article

VL - 7

SP - 638

EP - 647

JO - Organic Chemistry Frontiers

JF - Organic Chemistry Frontiers

SN - 2052-4110

IS - 4

ER -

ID: 49359043