Research output: Contribution to journal › Article › peer-review
Effects of tyrosine and tryptophan supplements on the vital indicators in mice differently prone to diet-induced obesity. / Gmoshinski, Ivan V.; Shipelin, Vladimir A.; Trusov, Nikita V.; Apryatin, Sergey A.; Mzhelskaya, Kristina V.; Shumakova, Antonina A.; Timonin, Andrey N.; Riger, Nikolay A.; Nikityuk, Dmitry B.
In: International Journal of Molecular Sciences, Vol. 22, No. 11, 01.06.2021.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Effects of tyrosine and tryptophan supplements on the vital indicators in mice differently prone to diet-induced obesity
AU - Gmoshinski, Ivan V.
AU - Shipelin, Vladimir A.
AU - Trusov, Nikita V.
AU - Apryatin, Sergey A.
AU - Mzhelskaya, Kristina V.
AU - Shumakova, Antonina A.
AU - Timonin, Andrey N.
AU - Riger, Nikolay A.
AU - Nikityuk, Dmitry B.
PY - 2021/6/1
Y1 - 2021/6/1
N2 - We studied the effects of the addition of large neutral amino acids, such as tyrosine (Tyr) and tryptophan (Trp), in mice DBA/2J and tetrahybrid mice DBCB receiving a high-fat, high-carbohydrate diet (HFCD) for 65 days. The locomotor activity, anxiety, muscle tone, mass of internal organs, liver morphology, adipokines, cytokines, and biochemical indices of animals were assessed. The Tyr supplementation potentiated increased anxiety in EPM and contributed to a muscle tone increase, a decrease in the AST/ALT ratio, and an increase in protein anabolism in both mice strains. Tyr contributed to a decrease in liver fatty degeneration and ALT reduction only in DBCB that were sensitive to the development of obesity. The addition of Trp caused an increase in muscle tone and potentiated an increase in anxiety with age in animals of both genotypes. Trp had toxic effects on the livers of mice, which was manifested in increased fatty degeneration in DBCB, edema, and the appearance of micronuclei in DBA/2J. The main identified effects of Tyr on mice are considered in the light of its modulating effect on the dopamine neurotransmitter metabolism, while for the Trp supplement, effects were presumably associated with the synthesis of its toxic metabolites by representatives of the intestinal microflora.
AB - We studied the effects of the addition of large neutral amino acids, such as tyrosine (Tyr) and tryptophan (Trp), in mice DBA/2J and tetrahybrid mice DBCB receiving a high-fat, high-carbohydrate diet (HFCD) for 65 days. The locomotor activity, anxiety, muscle tone, mass of internal organs, liver morphology, adipokines, cytokines, and biochemical indices of animals were assessed. The Tyr supplementation potentiated increased anxiety in EPM and contributed to a muscle tone increase, a decrease in the AST/ALT ratio, and an increase in protein anabolism in both mice strains. Tyr contributed to a decrease in liver fatty degeneration and ALT reduction only in DBCB that were sensitive to the development of obesity. The addition of Trp caused an increase in muscle tone and potentiated an increase in anxiety with age in animals of both genotypes. Trp had toxic effects on the livers of mice, which was manifested in increased fatty degeneration in DBCB, edema, and the appearance of micronuclei in DBA/2J. The main identified effects of Tyr on mice are considered in the light of its modulating effect on the dopamine neurotransmitter metabolism, while for the Trp supplement, effects were presumably associated with the synthesis of its toxic metabolites by representatives of the intestinal microflora.
KW - Behavior
KW - Cytokines
KW - Inflammation
KW - Liver morphology
KW - Mice
KW - Obesity
KW - Tryptophan
KW - Tyrosine
UR - http://www.scopus.com/inward/record.url?scp=85106937107&partnerID=8YFLogxK
U2 - 10.3390/ijms22115956
DO - 10.3390/ijms22115956
M3 - Article
C2 - 34073081
AN - SCOPUS:85106937107
VL - 22
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1422-0067
IS - 11
ER -
ID: 115015686