Research output: Contribution to journal › Article › peer-review
Effects of quercetin on the neuromotor function and behavioral responses of Wistar and Zucker rats fed a high-fat and high-carbohydrate diet. / Mzhelskaya, Kristina V.; Shipelin, Vladimir A.; Shumakova, Antonina A.; Musaeva, Anna D.; Soto, Jorge S.; Riger, Nikolay A.; Trusov, Nikita V.; Kirbaeva, Natalya V.; Apryatin, Sergey A.; Gmoshinski, Ivan V.
In: Behavioural Brain Research, Vol. 378, 27.01.2020.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Effects of quercetin on the neuromotor function and behavioral responses of Wistar and Zucker rats fed a high-fat and high-carbohydrate diet
AU - Mzhelskaya, Kristina V.
AU - Shipelin, Vladimir A.
AU - Shumakova, Antonina A.
AU - Musaeva, Anna D.
AU - Soto, Jorge S.
AU - Riger, Nikolay A.
AU - Trusov, Nikita V.
AU - Kirbaeva, Natalya V.
AU - Apryatin, Sergey A.
AU - Gmoshinski, Ivan V.
PY - 2020/1/27
Y1 - 2020/1/27
N2 - Quercetin can affect some pathological manifestations in obesity. The mechanism underlying the presumed therapeutic effect of quercetin is probably related to the influence on the central processes regulating energy homeostasis. Thus, the purpose of this study was to examine the effect of quercetin on the neuromotor and behavioral functions in Zucker (Z) and Wistar (W) rats with genetically and/or diet-induced obesity. Rats of both strains received balanced or high fat and fructose diet (HFCD) in a 62-day experiment or the same diets supplemented with quercetin at the dose of 50 mg/kg body weight per day. The neuromotor function and behavioral responses were examined using the grip strength test, open field test, elevated plus maze test and conditioned passive avoidance response (CPAR) test. The quercetin potentiated a decrease in anxiety in W rats consumed HFCD and this effect was absent in Z rats with a defect in the leptin receptor gene. In contrast, quercetin increased locomotor activity and impaired short-term memory in the CPAR test only in Z rats with the absence of normal leptin reception. Against the background of the identified changes quercetin exerted significant effects on the lipid and nitrogen metabolism indices such as HDL cholesterol, AsAT/AlAT activities ratio, urea level as well as body and fat mass that were different in Z and W rats. The data obtained show that the effects of quercetin on behavior vary significantly between two strains of rat and consequently are mediated by processes of leptin reception.
AB - Quercetin can affect some pathological manifestations in obesity. The mechanism underlying the presumed therapeutic effect of quercetin is probably related to the influence on the central processes regulating energy homeostasis. Thus, the purpose of this study was to examine the effect of quercetin on the neuromotor and behavioral functions in Zucker (Z) and Wistar (W) rats with genetically and/or diet-induced obesity. Rats of both strains received balanced or high fat and fructose diet (HFCD) in a 62-day experiment or the same diets supplemented with quercetin at the dose of 50 mg/kg body weight per day. The neuromotor function and behavioral responses were examined using the grip strength test, open field test, elevated plus maze test and conditioned passive avoidance response (CPAR) test. The quercetin potentiated a decrease in anxiety in W rats consumed HFCD and this effect was absent in Z rats with a defect in the leptin receptor gene. In contrast, quercetin increased locomotor activity and impaired short-term memory in the CPAR test only in Z rats with the absence of normal leptin reception. Against the background of the identified changes quercetin exerted significant effects on the lipid and nitrogen metabolism indices such as HDL cholesterol, AsAT/AlAT activities ratio, urea level as well as body and fat mass that were different in Z and W rats. The data obtained show that the effects of quercetin on behavior vary significantly between two strains of rat and consequently are mediated by processes of leptin reception.
KW - Behavioral reactions
KW - In vivo model
KW - Leptin
KW - Neuromotor responses
KW - Obesity
KW - Rats
UR - http://www.scopus.com/inward/record.url?scp=85073114661&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2019.112270
DO - 10.1016/j.bbr.2019.112270
M3 - Article
C2 - 31585131
AN - SCOPUS:85073114661
VL - 378
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
ER -
ID: 115016357