Research output: Contribution to journal › Article › peer-review
Effects of oxytocin and prostaglandin F2α (enzaprost) on platelet aggregation. / Ailamazyan, E. K.; Petrishchev, N. N.; Vivulanets, E. V.; Maryutina, L. V.; Mindukshev, I. V.; Khachaturyan, A. R.
In: Bulletin of Experimental Biology and Medicine, Vol. 134, No. 5, 01.11.2002, p. 439-441.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Effects of oxytocin and prostaglandin F2α (enzaprost) on platelet aggregation
AU - Ailamazyan, E. K.
AU - Petrishchev, N. N.
AU - Vivulanets, E. V.
AU - Maryutina, L. V.
AU - Mindukshev, I. V.
AU - Khachaturyan, A. R.
PY - 2002/11/1
Y1 - 2002/11/1
N2 - The effects of uterotonic agents (oxytocin and enzaprost) on platelet aggregation in pregnant and nonpregnant women were studied by low-angle light scattering. In nonpregnant women oxytocin produced different effects on ADP-induced platelet aggregation: potentiation at low (<200 nM) and inhibition at high (>400 nM) ADP concentrations. In pregnant women oxytocin did not modulate ADP-induced platelet aggregation or this effect was negligible. Enzaprost competitively inhibited ADP-induced platelet aggregation in all examined women (inhibition constant 84.8±25.7 nM).
AB - The effects of uterotonic agents (oxytocin and enzaprost) on platelet aggregation in pregnant and nonpregnant women were studied by low-angle light scattering. In nonpregnant women oxytocin produced different effects on ADP-induced platelet aggregation: potentiation at low (<200 nM) and inhibition at high (>400 nM) ADP concentrations. In pregnant women oxytocin did not modulate ADP-induced platelet aggregation or this effect was negligible. Enzaprost competitively inhibited ADP-induced platelet aggregation in all examined women (inhibition constant 84.8±25.7 nM).
KW - Labor
KW - Oxytocin
KW - Platelet aggregation
KW - Pregnancy
KW - Prostaglandin F
UR - http://www.scopus.com/inward/record.url?scp=0037616395&partnerID=8YFLogxK
U2 - 10.1023/A:1022677927836
DO - 10.1023/A:1022677927836
M3 - Article
C2 - 12802445
AN - SCOPUS:0037616395
VL - 134
SP - 439
EP - 441
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 5
ER -
ID: 87787840