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Effect of TT genotype of the vitamin D receptor gene on bone mineral density in dialysis patients. / Shishkin, A. N.; Mazurenko, S. O.; Aseyev, M. V.

In: Terapevticheskii Arkhiv, Vol. 82, No. 6, 2010, p. 39-43.

Research output: Contribution to journal › Article › peer-review

Harvard

Shishkin, AN, Mazurenko, SO & Aseyev, MV 2010, 'Effect of TT genotype of the vitamin D receptor gene on bone mineral density in dialysis patients', Terapevticheskii Arkhiv, vol. 82, no. 6, pp. 39-43.

APA

Shishkin, A. N., Mazurenko, S. O., & Aseyev, M. V. (2010). Effect of TT genotype of the vitamin D receptor gene on bone mineral density in dialysis patients. Terapevticheskii Arkhiv, 82(6), 39-43.

Vancouver

Shishkin AN, Mazurenko SO, Aseyev MV. Effect of TT genotype of the vitamin D receptor gene on bone mineral density in dialysis patients. Terapevticheskii Arkhiv. 2010;82(6):39-43.

Author

Shishkin, A. N. ; Mazurenko, S. O. ; Aseyev, M. V. / Effect of TT genotype of the vitamin D receptor gene on bone mineral density in dialysis patients. In: Terapevticheskii Arkhiv. 2010 ; Vol. 82, No. 6. pp. 39-43.

BibTeX

@article{468ed916de2d43d88c95365ee3702ea8,
title = "Effect of TT genotype of the vitamin D receptor gene on bone mineral density in dialysis patients",
abstract = "Aim: to evaluate the effect of TaqI genotypes of vitamin D receptor (VDR) gene polymorphism on bone mineral density (BMD) and the risk for secondary osteoporosis (OP) in patients on programmed hemodialysis. Subjects and methods. Eighty-two patients treated with long-term hemodialysis were examined. Along with physical examination, osteodensitometry was carried out and VDR gene polymorphism was studied in all the patients. Results. OP in the study skeletal parts was more common in the TT-genotype group. The serum concentration of intact parathyroid hormone and the activity of alkaline phosphatase were also higher in the TT-genotype group. However, the differences were statistically insignificant between the TT-, Tt-, and tt- genotype groups. BMD was lowest in each study skeletal parts in the TT-genotype group and this difference was statistically significant in the proximal femur, which was estimated by the Z index (p = 0.02). Conclusion. The results of the present study confirm the hypothesis that the VRD gene is a genetic determinant of bone metabolism in patients with chronic renal disease who receive long-term hemodialysis.",
keywords = "Hemodialysis, Hyperparathyroidism, Osteoporosis, VDR gene polymorphism",
author = "Shishkin, {A. N.} and Mazurenko, {S. O.} and Aseyev, {M. V.}",
note = "Copyright: Copyright 2011 Elsevier B.V., All rights reserved.",
year = "2010",
language = "English",
volume = "82",
pages = "39--43",
journal = "ТЕРАПЕВТИЧЕСКИЙ АРХИВ (TERAPEVTICHESKII ARKHIV)",
issn = "0040-3660",
publisher = "Медицина",
number = "6",

}

RIS

TY - JOUR

T1 - Effect of TT genotype of the vitamin D receptor gene on bone mineral density in dialysis patients

AU - Shishkin, A. N.

AU - Mazurenko, S. O.

AU - Aseyev, M. V.

N1 - Copyright: Copyright 2011 Elsevier B.V., All rights reserved.

PY - 2010

Y1 - 2010

N2 - Aim: to evaluate the effect of TaqI genotypes of vitamin D receptor (VDR) gene polymorphism on bone mineral density (BMD) and the risk for secondary osteoporosis (OP) in patients on programmed hemodialysis. Subjects and methods. Eighty-two patients treated with long-term hemodialysis were examined. Along with physical examination, osteodensitometry was carried out and VDR gene polymorphism was studied in all the patients. Results. OP in the study skeletal parts was more common in the TT-genotype group. The serum concentration of intact parathyroid hormone and the activity of alkaline phosphatase were also higher in the TT-genotype group. However, the differences were statistically insignificant between the TT-, Tt-, and tt- genotype groups. BMD was lowest in each study skeletal parts in the TT-genotype group and this difference was statistically significant in the proximal femur, which was estimated by the Z index (p = 0.02). Conclusion. The results of the present study confirm the hypothesis that the VRD gene is a genetic determinant of bone metabolism in patients with chronic renal disease who receive long-term hemodialysis.

AB - Aim: to evaluate the effect of TaqI genotypes of vitamin D receptor (VDR) gene polymorphism on bone mineral density (BMD) and the risk for secondary osteoporosis (OP) in patients on programmed hemodialysis. Subjects and methods. Eighty-two patients treated with long-term hemodialysis were examined. Along with physical examination, osteodensitometry was carried out and VDR gene polymorphism was studied in all the patients. Results. OP in the study skeletal parts was more common in the TT-genotype group. The serum concentration of intact parathyroid hormone and the activity of alkaline phosphatase were also higher in the TT-genotype group. However, the differences were statistically insignificant between the TT-, Tt-, and tt- genotype groups. BMD was lowest in each study skeletal parts in the TT-genotype group and this difference was statistically significant in the proximal femur, which was estimated by the Z index (p = 0.02). Conclusion. The results of the present study confirm the hypothesis that the VRD gene is a genetic determinant of bone metabolism in patients with chronic renal disease who receive long-term hemodialysis.

KW - Hemodialysis

KW - Hyperparathyroidism

KW - Osteoporosis

KW - VDR gene polymorphism

UR - http://www.scopus.com/inward/record.url?scp=77955580735&partnerID=8YFLogxK

M3 - Article

C2 - 20731109

AN - SCOPUS:77955580735

VL - 82

SP - 39

EP - 43

JO - ТЕРАПЕВТИЧЕСКИЙ АРХИВ (TERAPEVTICHESKII ARKHIV)

JF - ТЕРАПЕВТИЧЕСКИЙ АРХИВ (TERAPEVTICHESKII ARKHIV)

SN - 0040-3660

IS - 6

ER -

ID: 76249337