The methods of circular dichroism, ultraviolet spectrophotometry, dynamic light scattering, viscometry, dynamic birefringence, and atomic force microscopy are employed to study the conformational properties of the DNA molecule during its complexation with oligopeptides. Samples with 2, 3, and 5 monomeric Llysine residues are used. Experimental data evidence that in the diluted solutions (with a low ionic strength) of DNA with oligopeptides (with 3 and 5 monomeric units) the condensation of the macromolecule is observed at specific peptide concentrations. For the bipeptide the DNA condensation in the solution is not observed. In the DNA solutions with a high ionic strength (1 M NaCl), oligopeptides do not affect the macromolecule size. Original Russian Text

Original languageEnglish
Pages (from-to)1202-1208
Number of pages7
JournalJournal of Structural Chemistry
Volume52
Issue number6
DOIs
StatePublished - Dec 2011

    Research areas

  • Condensation, DNA, Lysine, Oligopeptides

    Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

ID: 73389888