Standard

Effect of Chirality of Phenylalanine in a Copolymer with L-Lysine on the Self-Assembly and Properties of the Resulting Nanoparticles. / Коржикова-Влах, Евгения Георгиевна; Джужа, Аполлинария Юрьевна; Матвиенко, Влад; Платонова, Г.А.; Тенникова, Татьяна Борисовна.

In: Polymer Science. Series A, Vol. 66, No. 1, 01.02.2024, p. 57-68.

Research output: Contribution to journal › Article › peer-review

Harvard

Коржикова-Влах, ЕГ, Джужа, АЮ, Матвиенко, В, Платонова, ГА & Тенникова, ТБ 2024, 'Effect of Chirality of Phenylalanine in a Copolymer with L-Lysine on the Self-Assembly and Properties of the Resulting Nanoparticles', Polymer Science. Series A, vol. 66, no. 1, pp. 57-68. https://doi.org/10.1134/s0965545x24600194

APA

Коржикова-Влах, Е. Г., Джужа, А. Ю., Матвиенко, В., Платонова, Г. А., & Тенникова, Т. Б. (2024). Effect of Chirality of Phenylalanine in a Copolymer with L-Lysine on the Self-Assembly and Properties of the Resulting Nanoparticles. Polymer Science. Series A, 66(1), 57-68. https://doi.org/10.1134/s0965545x24600194

Vancouver

Коржикова-Влах ЕГ, Джужа АЮ, Матвиенко В, Платонова ГА, Тенникова ТБ. Effect of Chirality of Phenylalanine in a Copolymer with L-Lysine on the Self-Assembly and Properties of the Resulting Nanoparticles. Polymer Science. Series A. 2024 Feb 1;66(1):57-68. https://doi.org/10.1134/s0965545x24600194

Author

Коржикова-Влах, Евгения Георгиевна ; Джужа, Аполлинария Юрьевна ; Матвиенко, Влад ; Платонова, Г.А. ; Тенникова, Татьяна Борисовна. / Effect of Chirality of Phenylalanine in a Copolymer with L-Lysine on the Self-Assembly and Properties of the Resulting Nanoparticles. In: Polymer Science. Series A. 2024 ; Vol. 66, No. 1. pp. 57-68.

BibTeX

@article{b043f96796364cc080ed3e20eb78cbda,
title = "Effect of Chirality of Phenylalanine in a Copolymer with L-Lysine on the Self-Assembly and Properties of the Resulting Nanoparticles",
abstract = "Abstract: Amphiphilic copolymers of amino acids capable of self-assembly in aqueous media into nanoparticles are of interest as potential drug delivery systems. In this work, a series of amphiphilic copolymers of lysine and phenylalanine with different chirality and content of monomer units are synthesized and characterized. Effect of the composition of copolymers on the characteristics and physicochemical and biological properties of nanoparticles formed due to self-assembly is studied. Specifically, the hydrodynamic characteristics of nanoparticles are determined and compared with average diameters in the dry state. Critical aggregation concentrations are assessed and effect of the рН of medium and the time of incubation on the stability of dispersions of nanoparticles is investigated. In addition, the data on the cytotoxicity of nanosystems depending on the chirality of hydrophobic amino acid are obtained.",
author = "Коржикова-Влах, {Евгения Георгиевна} and Джужа, {Аполлинария Юрьевна} and Влад Матвиенко and Г.А. Платонова and Тенникова, {Татьяна Борисовна}",
year = "2024",
month = feb,
day = "1",
doi = "10.1134/s0965545x24600194",
language = "English",
volume = "66",
pages = "57--68",
journal = "Polymer Science - Series A",
issn = "0965-545X",
publisher = "МАИК {"}Наука/Интерпериодика{"}",
number = "1",

}

RIS

TY - JOUR

T1 - Effect of Chirality of Phenylalanine in a Copolymer with L-Lysine on the Self-Assembly and Properties of the Resulting Nanoparticles

AU - Коржикова-Влах, Евгения Георгиевна

AU - Джужа, Аполлинария Юрьевна

AU - Матвиенко, Влад

AU - Платонова, Г.А.

AU - Тенникова, Татьяна Борисовна

PY - 2024/2/1

Y1 - 2024/2/1

N2 - Abstract: Amphiphilic copolymers of amino acids capable of self-assembly in aqueous media into nanoparticles are of interest as potential drug delivery systems. In this work, a series of amphiphilic copolymers of lysine and phenylalanine with different chirality and content of monomer units are synthesized and characterized. Effect of the composition of copolymers on the characteristics and physicochemical and biological properties of nanoparticles formed due to self-assembly is studied. Specifically, the hydrodynamic characteristics of nanoparticles are determined and compared with average diameters in the dry state. Critical aggregation concentrations are assessed and effect of the рН of medium and the time of incubation on the stability of dispersions of nanoparticles is investigated. In addition, the data on the cytotoxicity of nanosystems depending on the chirality of hydrophobic amino acid are obtained.

AB - Abstract: Amphiphilic copolymers of amino acids capable of self-assembly in aqueous media into nanoparticles are of interest as potential drug delivery systems. In this work, a series of amphiphilic copolymers of lysine and phenylalanine with different chirality and content of monomer units are synthesized and characterized. Effect of the composition of copolymers on the characteristics and physicochemical and biological properties of nanoparticles formed due to self-assembly is studied. Specifically, the hydrodynamic characteristics of nanoparticles are determined and compared with average diameters in the dry state. Critical aggregation concentrations are assessed and effect of the рН of medium and the time of incubation on the stability of dispersions of nanoparticles is investigated. In addition, the data on the cytotoxicity of nanosystems depending on the chirality of hydrophobic amino acid are obtained.

UR - https://www.mendeley.com/catalogue/5835dbf1-6dcf-3d3b-a03c-874d4eebfd4b/

U2 - 10.1134/s0965545x24600194

DO - 10.1134/s0965545x24600194

M3 - Article

VL - 66

SP - 57

EP - 68

JO - Polymer Science - Series A

JF - Polymer Science - Series A

SN - 0965-545X

IS - 1

ER -

ID: 121684683