In the article based on authentic investigation and research, the problem of medical waste management, its social, ecologohygienic and epidemiological urgency have been described. The dynamics of establishment and content of the national sanitary guidelines and regulations of 1999 and 2010 (co-authors of the current article participated in development of several of them) has been followed up; based on international sources, there have been considered critical comments of experts to these documents; in order to be understood clearly, some of the guidelines provisions' versions have been updated.