Dronedarone in high-risk permanent atrial fibrillation

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Dronedarone in high-risk permanent atrial fibrillation. / Connolly, Stuart J.; Camm, A. John; Halperin, Jonathan L.; Joyner, Campbell; Alings, Marco; Amerena, John; Atar, Dan; Avezum, Álvaro; Blomström, Per; Borggrefe, Martin; Budaj, Andrzej; Chen, Shih Ann; Ching, Chi Keong; Commerford, Patrick; Dans, Antonio; Davy, Jean Marc; Delacrétaz, Etienne; Di Pasquale, Giuseppe; Diaz, Rafael; Dorian, Paul; Flaker, Greg; Golitsyn, Sergey; Gonzalez-Hermosillo, Antonio; Granger, Christopher B.; Heidbüchel, Hein; Kautzner, Josef; Kim, June Soo; Lanas, Fernando; Lewis, Basil S.; Merino, Jose L.; Morillo, Carlos; Murin, Jan; Narasimhan, Calambur; Paolasso, Ernesto; Parkhomenko, Alexander; Peters, Nicholas S.; Sim, Kui Hian; Stiles, Martin K.; Tanomsup, Supachai; Toivonen, Lauri; Tomcsányi, János; Torp-Pedersen, Christian; Tse, Hung Fat; Vardas, Panos; Vinereanu, Dragos; Xavier, Denis; Zhu, Jun; Zhu, Jun Ren; Baret-Cormel, Lydie; Weinling, Estelle; Staiger, Christoph; Yusuf, Salim; Chrolavicius, Susan; Afzal, Rizwan; Hohnloser, Stefan H.; Wyse, D. G.; Cairns, J.; Pfeffer, M.; Pocock, S.; Wellens, H.; Atra, M.; Basart, D. C.; Bornstein, N. M.; Brandes, A.; De Raedt, H.; Doiny, D.; Duray, G. Z.; Dvorakova, H.; Estrada, A.; Fodor, G.; Gross, B.; Halon, D.; Häppölä, O.; Hart, R.; Healey, J. S.; Jacobsson, F.; Kalvach, P.; Krahn, A.; Laine, M.; Maggioni, A. P.; Mairesse, G. H.; Muir, S. W.; Norrving, B.; Peeters, A.; Pizzolato, G.; Ruiz-Ares, G.; Veltmann, C.; Verdecchia, P.; Widimsky, P.; Zaborski, J.; Zimlichman, R.; Demaerschalk, B.; Diener, H. C.; Tirschwell, D.; Holmes, E.; Lawrence, M.; Bajkor, S.; McCready, T.; Meeks, B.; Gao, P.; Smith, J.; Yang, X.; Yuan, F.; Blake, L.; Dunlop, V.; Gasic, Z.; Molnar, S.; Nieuwlaat, R.; Pasadyn, E.; Sephton, J.; Tuhy, R.; Wild, M.; Caccavo, A.; Cartasegna, L. R.; Cuneo, C. A.; Garrido, M. A.; Guzman, L. A.; Hominal, M. A.; Llanos, J. R.; MacKinnon, I. J.; Vico, M. L.; Vogel, D. R.; Zaidman, C. J.; Colquhoun, D.; Counsell, J. T.; de Looze, F. J.; Durbidge, V. K.; Purnell, P. W.; Soward, A. L.; van Gaal, W. J.; William, M.; Burkart-Kuettner, D.; Huber, K.; Pieske, B.; Roithinger, F. X.; Catez, E. M.; Cools, F. J.; De Roy, L.; De Vusser, P.; De Wolf, L.; Deceuninck, O.; Dilling-Boer, D.; Goethals, M. P.; Paparella, G.; Provenier, F.; Scavée, C.; Vervoort, G.; Botelho, R. V.; Braga, J. S.; de Paola, A. A.; de Souza, W. K.; Genta, P. R.; Hernandes, M. E.; Jaber, J.; Lorga-Filho, A. M.; Manenti, E. R.; Jorge, J. C.; Précoma, D. B.; Reis, G.; Rossi, P. R.; Sousa, A. C.; Zimmermann, S. L.; Gronkova, N. I.; Tumbev, H. S.; Bose, S.; Boucher, P.; Cha, J. Y.; Constance, C. M.; Costi, P.; Coutu, B.; Gupta, M.; Kouz, S.; Lam, A. S.; Leather, R.; Pandey, A. S.; Rebane, T.; Savard, D.; St-Hilaire, R.; Vizel, S.; Cobos, J. L.; Corbalan, R.; Donoso, H.; Escobar, E.; Medina, M. E.; Potthoff, S. H.; Raffo, C. A.; Saavedra, J. G.; Tijerino, M. A.; Ballek, L.; Boček, P.; Choura, M.; Dědek, V.; Egert, A.; Hudcovic, M.; Klimsa, Z.; Labrova, R.; Malecha, J.; Petrova, I.; Podpera, I.; Poklopová, Z.; Velimsky, T.; Dixen, U.; Egstrup, K.; Frost, L.; Gislason, G.; Husted, S. E.; Jakobsen, T. J.; Jeppesen, J.; Kaae Dodt, K.; Klarlund, K. K.; Melchior, T. M.; Nielsen, H.; Skagen, K.; Aro, A.; Huikuri, H. V.; Kyto, V.; Nyman, K.; Utriainen, S.; Ylitalo, A.; Fouche, R.; Gacem, K.; Mansour, M.; Pasquie, J. L.; Poulard, J. E.; Appel, K. F.; Axthelm, C.; Bosch, R. F.; Bushoven, P.; Darius, H.; Grönefeld, G. C.; Hanefeld, C.; Haverkamp, W.; Horacek, T.; Israel, C. W.; Killat, H.; Klingenheben, T.; Kreuzer, J.; Leicht, M.; Licka, M. B.; Niethammer, M.; Rieker, W. A.; Salbach, P.; Schenkenberger, I.; Schmidt, A.; Spitzer, S. G.; Toursarkissian, N.; Veltkamp, R.; Weissbrodt, M.; Winkelmann, B. R.; Wurziger, J.; Zemmrich, C.; Vogiatzis, I. A.; Siu, C. W.; Ferencz, G.; Katona, A.; Keltai, K.; Kovács, Z.; Laszlo, Z.; Poor, F.; Szakal, I.; Toldy-Schedel, E.; Vertes, A.; Eldar, M.; Elias, M.; Freedberg, N. A.; Halabi, S.; Hamoud, S.; Katz, A.; Klainman, E. E.; Marmor, A.; Medina, A.; Mosseri, M.; Motro, M.; Stein, G. Y.; Weiss, T.; Zeltser, D.; Calabrese, D.; Cosmi, F.; de Tommasi, F.; Glorioso, N.; Gulizia, M. M.; Mennuni, M.; Piovaccari, G.; Chee, K. H.; Alcocer Gamba, M. A.; Alvarado-Ruiz, R.; Arenas, J. L.; Bayram Llamas, E.; Calvo Vargas, C. G.; Carrillo, J.; Fernandez-Bonetti, P.; Gomez, J. F.; Llamas-Esperón, G.; Lopez Rosas, E.; Matadamas Hernandez, N.; Ramirez Isunza, J. M.; Salcido, E.; Velasco-Sanchez, R. G.; Bartels, G. L.; Bracke, F.; Bruning, T. A.; Cozijnsen, L.; de Weerd, G. J.; den Hartog, F. R.; Geertman, H.; Hamraoui, K.; Heesen, W. F.; Hunze, I.; Idzerda, H. H.; Kragten, J.; Liem, A. H.; Lok, D. J.; Moens, A.; Plomp, J.; Pos, L.; Ramdat Misier, A. R.; Remmen, J. J.; Ruiter, J. H.; Scholten, M. F.; Swart, H. P.; Tans, J. G.; Theunissen, L.; Tukkie, R.; van der Heijden, R.; Van Doorn, D. J.; Van Gelder, I. C.; van Hessen, M. W.; Westendorp, P. H.; Willems, A. R.; Zoet-Nugteren, S. K.; Aitken, S. A.; Elliott, J. M.; Scales, J. E.; Scott, B.; Ternouth, I. F.; Tisch, J.; Berg-Johansen, J.; Husvik, M. A.; Istad, H.; Risberg, K.; Rød, R.; Sirnes, P. A.; Skjelvan, G. K.; Bednarski, J.; Bronisz, M.; Bryniarski, L.; Gniot, J. R.; Kawka-Urbanek, T.; Kopaczewski, J.; Miekus, P.; Pasierski, T. J.; Piepiorka, M.; Prochaczek, F.; Raczak, G.; Rekosz, J.; Stepinska, J.; Szelemej, R.; Szpajer, M.; Zaborska, B.; Cinteza, M. A.; Ciobanu, A. O.; Dan, A. R.; Dimulescu, D.; Fierbinteanu-Braticevici, C. G.; Istratoaie, O.; Lighezan, D. F.; Minescu, B.; Vintila, M. M.; Akhmedzhanov, N. M.; Alikhanov, B. A.; Barabashkina, A. V.; Barbarash, O.; Barbarich, V. B.; Bart, B. Y.; Boyarkin, M. V.; Burova, N. N.; Bychkova, L.; Fitilev, S. B.; Gizatulina, T. P.; Khaisheva, L. A.; Konstantinov, V. O.; Koziolova, N.; Lesnov, V.; Lukyanov, Y.; Lyamina, N. P.; Malkina, T. A.; Miller, O. N.; Moiseev, V.; Novikova, N. V.; Orlikova, O. V.; Orlov, V. A.; Osipenko, M. F.; Panchenko, E.; Platonov, D. Y.; Popov, S. V.; Rafalakiy, V. V.; Ruda, M. Y.; Seliverstova, S. A.; Shalaev, S. V.; Shchekotov, V. V.; Shubik, Y.; Shvarts, Y.; Sulimov, V. A.; Tretyakova, T. V.; Vaniev, S.; Vishnevsky, A.; Yakusevich, V. V.; Yakushin, S. S.; Zrazhevskiy, K. N.; Teo, W. S.; Bugan, V.; Kaliská, G.; Masarovičová, M.; Nociar, J.; Pella, D.; Uhliar, R.; Bushidi, M.; Engelbrecht, J. M.; Okreglicki, A. M.; Pillay, T.; Snyders, F. A.; Theron, H. D.; Venter, T. P.; Cho, J. G.; Kim, D.; Kim, Y. H.; Lee, M. H.; Oh, S.; On, Y. K.; Rho, T. H.; Shin, D. H.; Alzueta, J.; Bruguera, J.; Castrejon, S.; Díaz-Infante, E.; Grigorian Shamagian, L.; Martínez-Rubio, A.; Mont, L.; Vida, M.; Viñolas, X.; Berglund, S. T.; Blomstrom-Lundqvist, C.; Cherfan, P.; Jakobsson, S.; Johansson, L.; Juhlin, T.; Kozak, P.; Rönn, F.; Rosenqvist, M.; Sprock, L.; Gallino, A. F.; Lyrer, P. A.; Moccetti, T.; Chen, M. C.; Hu, Y. F.; Lin, J. L.; Wen, M. S.; Karpenko, O. I.; Kozhukhov, S.; Kraiz, I.; Pavlyk, S. S.; Potapenko, P. I.; Prokhorov, O. V.; Prudkyi, I. V.; Prykhodko, V. Y.; Rudenko, L. V.; Sychov, O. S.; Tseluyko, V. I.; Vizir, V. A.; Zharinov, O. J.; Aggarwal, R.; Copley, A. J.; Davey, P. P.; Kadr, H. H.; Lip, G. Y.; Lord, S.; Moriarty, A. J.; Pye, M. P.; Ryding, A. D.; Savelieva, I.; Abadier, R.; Ahmad, S.; Ahmad, Z. M.; Alexander, K. P.; Alfieri, A. D.; Baker, S.; Ball, E. M.; Baruch, L.; Bellam, R. P.; Benjamin, S. A.; Brill, D. A.; Browne, K. F.; Call, J. T.; Carr, K. W.; Chandna, H.; Chen, C.; Chen, Y. C.; Chilakapati, V. S.; Colan, D.; Cossu, S. F.; Dean, J.; DeFehr, S. P.; Dempsey, S. J.; Desai, V. S.; Dohrmann, M. L.; Ellison, H. S.; Emlein, G.; Farris, N.; Fields, R. H.; Fishbein, G. J.; Flores, E. A.; Friedlander, I. R.; Gelernt, M. D.; Genovely, H. C.; Gillespie, E. L.; Go, B. M.; Gottlieb, D. W.; Grena, P. G.; Guarnieri, T.; Gupta, D. K.; Haidar, A. A.; Hamroff, G. S.; Hargrove, J. L.; Haskel, E. J.; Hearne, S. E.; Henderson, D. A.; Herre, J. M.; Herzog, W. R.; Hoppe, B. L.; Hotchkiss, D.; Humiston, D. J.; Igic, P. G.; Jackson, B. K.; Jacobson, A. K.; Jaffrani, N. A.; Jarzabkowski, D.; Jazayeri, M. R.; Kaplan, A. J.; Khant, R. N.; Kim, A. C.; Klancke, K. A.; Kosinski, E. J.; Kovach, M.; Kramer, J. H.; Lader, E. W.; LeLevier, J. A.; Lepor, N. E.; Levy, R. M.; Littlefield, R. H.; Marple, R. N.; McGrew, F. A.; McWilliams, M. J.; Meholick, A.; Mirro, M. J.; Murphy, J. F.; Murray, A. V.; Nadar, V. K.; Nanna, M.; Navarrete-Casas, A. J.; O'Dea, D. J.; O'Neill, P. G.; Oza, S. R.; Patel, R. J.; Perlmutter, N. S.; Pierce, D. L.; Promisloff, S. D.; Pulido, J. G.; Rahman, J.; Rhodes, D. V.; Rubin, A. M.; Sandberg, J. H.; Sandesara, C. M.; Schreiman, R.; Shah, A.; Sheikh, K. H.; Singh, N.; Sloan, S. B.; Sofley, C. W.; Staniloae, C. S.; Teixeira, J. M.; Tuan, W. M.; Vaid, B. R.; Vicari, R. M.; Vijay, N. K.; Vora, K. N.; Weiss, R. J.; Wenocur, H. S.; Yunus, A.

In: New England Journal of Medicine, Vol. 365, No. 24, 15.12.2011, p. 2268-2276.

Research output: Contribution to journal › Article › peer-review

Harvard

Connolly, SJ, Camm, AJ, Halperin, JL, Joyner, C, Alings, M, Amerena, J, Atar, D, Avezum, Á, Blomström, P, Borggrefe, M, Budaj, A, Chen, SA, Ching, CK, Commerford, P, Dans, A, Davy, JM, Delacrétaz, E, Di Pasquale, G, Diaz, R, Dorian, P, Flaker, G, Golitsyn, S, Gonzalez-Hermosillo, A, Granger, CB, Heidbüchel, H, Kautzner, J, Kim, JS, Lanas, F, Lewis, BS, Merino, JL, Morillo, C, Murin, J, Narasimhan, C, Paolasso, E, Parkhomenko, A, Peters, NS, Sim, KH, Stiles, MK, Tanomsup, S, Toivonen, L, Tomcsányi, J, Torp-Pedersen, C, Tse, HF, Vardas, P, Vinereanu, D, Xavier, D, Zhu, J, Zhu, JR, Baret-Cormel, L, Weinling, E, Staiger, C, Yusuf, S, Chrolavicius, S, Afzal, R, Hohnloser, SH, Wyse, DG, Cairns, J, Pfeffer, M, Pocock, S, Wellens, H, Atra, M, Basart, DC, Bornstein, NM, Brandes, A, De Raedt, H, Doiny, D, Duray, GZ, Dvorakova, H, Estrada, A, Fodor, G, Gross, B, Halon, D, Häppölä, O, Hart, R, Healey, JS, Jacobsson, F, Kalvach, P, Krahn, A, Laine, M, Maggioni, AP, Mairesse, GH, Muir, SW, Norrving, B, Peeters, A, Pizzolato, G, Ruiz-Ares, G, Veltmann, C, Verdecchia, P, Widimsky, P, Zaborski, J, Zimlichman, R, Demaerschalk, B, Diener, HC, Tirschwell, D, Holmes, E, Lawrence, M, Bajkor, S, McCready, T, Meeks, B, Gao, P, Smith, J, Yang, X, Yuan, F, Blake, L, Dunlop, V, Gasic, Z, Molnar, S, Nieuwlaat, R, Pasadyn, E, Sephton, J, Tuhy, R, Wild, M, Caccavo, A, Cartasegna, LR, Cuneo, CA, Garrido, MA, Guzman, LA, Hominal, MA, Llanos, JR, MacKinnon, IJ, Vico, ML, Vogel, DR, Zaidman, CJ, Colquhoun, D, Counsell, JT, de Looze, FJ, Durbidge, VK, Purnell, PW, Soward, AL, van Gaal, WJ, William, M, Burkart-Kuettner, D, Huber, K, Pieske, B, Roithinger, FX, Catez, EM, Cools, FJ, De Roy, L, De Vusser, P, De Wolf, L, Deceuninck, O, Dilling-Boer, D, Goethals, MP, Paparella, G, Provenier, F, Scavée, C, Vervoort, G, Botelho, RV, Braga, JS, de Paola, AA, de Souza, WK, Genta, PR, Hernandes, ME, Jaber, J, Lorga-Filho, AM, Manenti, ER, Jorge, JC, Précoma, DB, Reis, G, Rossi, PR, Sousa, AC, Zimmermann, SL, Gronkova, NI, Tumbev, HS, Bose, S, Boucher, P, Cha, JY, Constance, CM, Costi, P, Coutu, B, Gupta, M, Kouz, S, Lam, AS, Leather, R, Pandey, AS, Rebane, T, Savard, D, St-Hilaire, R, Vizel, S, Cobos, JL, Corbalan, R, Donoso, H, Escobar, E, Medina, ME, Potthoff, SH, Raffo, CA, Saavedra, JG, Tijerino, MA, Ballek, L, Boček, P, Choura, M, Dědek, V, Egert, A, Hudcovic, M, Klimsa, Z, Labrova, R, Malecha, J, Petrova, I, Podpera, I, Poklopová, Z, Velimsky, T, Dixen, U, Egstrup, K, Frost, L, Gislason, G, Husted, SE, Jakobsen, TJ, Jeppesen, J, Kaae Dodt, K, Klarlund, KK, Melchior, TM, Nielsen, H, Skagen, K, Aro, A, Huikuri, HV, Kyto, V, Nyman, K, Utriainen, S, Ylitalo, A, Fouche, R, Gacem, K, Mansour, M, Pasquie, JL, Poulard, JE, Appel, KF, Axthelm, C, Bosch, RF, Bushoven, P, Darius, H, Grönefeld, GC, Hanefeld, C, Haverkamp, W, Horacek, T, Israel, CW, Killat, H, Klingenheben, T, Kreuzer, J, Leicht, M, Licka, MB, Niethammer, M, Rieker, WA, Salbach, P, Schenkenberger, I, Schmidt, A, Spitzer, SG, Toursarkissian, N, Veltkamp, R, Weissbrodt, M, Winkelmann, BR, Wurziger, J, Zemmrich, C, Vogiatzis, IA, Siu, CW, Ferencz, G, Katona, A, Keltai, K, Kovács, Z, Laszlo, Z, Poor, F, Szakal, I, Toldy-Schedel, E, Vertes, A, Eldar, M, Elias, M, Freedberg, NA, Halabi, S, Hamoud, S, Katz, A, Klainman, EE, Marmor, A, Medina, A, Mosseri, M, Motro, M, Stein, GY, Weiss, T, Zeltser, D, Calabrese, D, Cosmi, F, de Tommasi, F, Glorioso, N, Gulizia, MM, Mennuni, M, Piovaccari, G, Chee, KH, Alcocer Gamba, MA, Alvarado-Ruiz, R, Arenas, JL, Bayram Llamas, E, Calvo Vargas, CG, Carrillo, J, Fernandez-Bonetti, P, Gomez, JF, Llamas-Esperón, G, Lopez Rosas, E, Matadamas Hernandez, N, Ramirez Isunza, JM, Salcido, E, Velasco-Sanchez, RG, Bartels, GL, Bracke, F, Bruning, TA, Cozijnsen, L, de Weerd, GJ, den Hartog, FR, Geertman, H, Hamraoui, K, Heesen, WF, Hunze, I, Idzerda, HH, Kragten, J, Liem, AH, Lok, DJ, Moens, A, Plomp, J, Pos, L, Ramdat Misier, AR, Remmen, JJ, Ruiter, JH, Scholten, MF, Swart, HP, Tans, JG, Theunissen, L, Tukkie, R, van der Heijden, R, Van Doorn, DJ, Van Gelder, IC, van Hessen, MW, Westendorp, PH, Willems, AR, Zoet-Nugteren, SK, Aitken, SA, Elliott, JM, Scales, JE, Scott, B, Ternouth, IF, Tisch, J, Berg-Johansen, J, Husvik, MA, Istad, H, Risberg, K, Rød, R, Sirnes, PA, Skjelvan, GK, Bednarski, J, Bronisz, M, Bryniarski, L, Gniot, JR, Kawka-Urbanek, T, Kopaczewski, J, Miekus, P, Pasierski, TJ, Piepiorka, M, Prochaczek, F, Raczak, G, Rekosz, J, Stepinska, J, Szelemej, R, Szpajer, M, Zaborska, B, Cinteza, MA, Ciobanu, AO, Dan, AR, Dimulescu, D, Fierbinteanu-Braticevici, CG, Istratoaie, O, Lighezan, DF, Minescu, B, Vintila, MM, Akhmedzhanov, NM, Alikhanov, BA, Barabashkina, AV, Barbarash, O, Barbarich, VB, Bart, BY, Boyarkin, MV, Burova, NN, Bychkova, L, Fitilev, SB, Gizatulina, TP, Khaisheva, LA, Konstantinov, VO, Koziolova, N, Lesnov, V, Lukyanov, Y, Lyamina, NP, Malkina, TA, Miller, ON, Moiseev, V, Novikova, NV, Orlikova, OV, Orlov, VA, Osipenko, MF, Panchenko, E, Platonov, DY, Popov, SV, Rafalakiy, VV, Ruda, MY, Seliverstova, SA, Shalaev, SV, Shchekotov, VV, Shubik, Y, Shvarts, Y, Sulimov, VA, Tretyakova, TV, Vaniev, S, Vishnevsky, A, Yakusevich, VV, Yakushin, SS, Zrazhevskiy, KN, Teo, WS, Bugan, V, Kaliská, G, Masarovičová, M, Nociar, J, Pella, D, Uhliar, R, Bushidi, M, Engelbrecht, JM, Okreglicki, AM, Pillay, T, Snyders, FA, Theron, HD, Venter, TP, Cho, JG, Kim, D, Kim, YH, Lee, MH, Oh, S, On, YK, Rho, TH, Shin, DH, Alzueta, J, Bruguera, J, Castrejon, S, Díaz-Infante, E, Grigorian Shamagian, L, Martínez-Rubio, A, Mont, L, Vida, M, Viñolas, X, Berglund, ST, Blomstrom-Lundqvist, C, Cherfan, P, Jakobsson, S, Johansson, L, Juhlin, T, Kozak, P, Rönn, F, Rosenqvist, M, Sprock, L, Gallino, AF, Lyrer, PA, Moccetti, T, Chen, MC, Hu, YF, Lin, JL, Wen, MS, Karpenko, OI, Kozhukhov, S, Kraiz, I, Pavlyk, SS, Potapenko, PI, Prokhorov, OV, Prudkyi, IV, Prykhodko, VY, Rudenko, LV, Sychov, OS, Tseluyko, VI, Vizir, VA, Zharinov, OJ, Aggarwal, R, Copley, AJ, Davey, PP, Kadr, HH, Lip, GY, Lord, S, Moriarty, AJ, Pye, MP, Ryding, AD, Savelieva, I, Abadier, R, Ahmad, S, Ahmad, ZM, Alexander, KP, Alfieri, AD, Baker, S, Ball, EM, Baruch, L, Bellam, RP, Benjamin, SA, Brill, DA, Browne, KF, Call, JT, Carr, KW, Chandna, H, Chen, C, Chen, YC, Chilakapati, VS, Colan, D, Cossu, SF, Dean, J, DeFehr, SP, Dempsey, SJ, Desai, VS, Dohrmann, ML, Ellison, HS, Emlein, G, Farris, N, Fields, RH, Fishbein, GJ, Flores, EA, Friedlander, IR, Gelernt, MD, Genovely, HC, Gillespie, EL, Go, BM, Gottlieb, DW, Grena, PG, Guarnieri, T, Gupta, DK, Haidar, AA, Hamroff, GS, Hargrove, JL, Haskel, EJ, Hearne, SE, Henderson, DA, Herre, JM, Herzog, WR, Hoppe, BL, Hotchkiss, D, Humiston, DJ, Igic, PG, Jackson, BK, Jacobson, AK, Jaffrani, NA, Jarzabkowski, D, Jazayeri, MR, Kaplan, AJ, Khant, RN, Kim, AC, Klancke, KA, Kosinski, EJ, Kovach, M, Kramer, JH, Lader, EW, LeLevier, JA, Lepor, NE, Levy, RM, Littlefield, RH, Marple, RN, McGrew, FA, McWilliams, MJ, Meholick, A, Mirro, MJ, Murphy, JF, Murray, AV, Nadar, VK, Nanna, M, Navarrete-Casas, AJ, O'Dea, DJ, O'Neill, PG, Oza, SR, Patel, RJ, Perlmutter, NS, Pierce, DL, Promisloff, SD, Pulido, JG, Rahman, J, Rhodes, DV, Rubin, AM, Sandberg, JH, Sandesara, CM, Schreiman, R, Shah, A, Sheikh, KH, Singh, N, Sloan, SB, Sofley, CW, Staniloae, CS, Teixeira, JM, Tuan, WM, Vaid, BR, Vicari, RM, Vijay, NK, Vora, KN, Weiss, RJ, Wenocur, HS & Yunus, A 2011, 'Dronedarone in high-risk permanent atrial fibrillation', New England Journal of Medicine, vol. 365, no. 24, pp. 2268-2276. https://doi.org/10.1056/NEJMoa1109867, https://doi.org/10.1056/NEJMoa1109867

APA

Connolly, S. J., Camm, A. J., Halperin, J. L., Joyner, C., Alings, M., Amerena, J., Atar, D., Avezum, Á., Blomström, P., Borggrefe, M., Budaj, A., Chen, S. A., Ching, C. K., Commerford, P., Dans, A., Davy, J. M., Delacrétaz, E., Di Pasquale, G., Diaz, R., ... Yunus, A. (2011). Dronedarone in high-risk permanent atrial fibrillation. New England Journal of Medicine, 365(24), 2268-2276. https://doi.org/10.1056/NEJMoa1109867, https://doi.org/10.1056/NEJMoa1109867

Vancouver

Connolly SJ, Camm AJ, Halperin JL, Joyner C, Alings M, Amerena J et al. Dronedarone in high-risk permanent atrial fibrillation. New England Journal of Medicine. 2011 Dec 15;365(24):2268-2276. https://doi.org/10.1056/NEJMoa1109867, https://doi.org/10.1056/NEJMoa1109867

Author

Connolly, Stuart J. ; Camm, A. John ; Halperin, Jonathan L. ; Joyner, Campbell ; Alings, Marco ; Amerena, John ; Atar, Dan ; Avezum, Álvaro ; Blomström, Per ; Borggrefe, Martin ; Budaj, Andrzej ; Chen, Shih Ann ; Ching, Chi Keong ; Commerford, Patrick ; Dans, Antonio ; Davy, Jean Marc ; Delacrétaz, Etienne ; Di Pasquale, Giuseppe ; Diaz, Rafael ; Dorian, Paul ; Flaker, Greg ; Golitsyn, Sergey ; Gonzalez-Hermosillo, Antonio ; Granger, Christopher B. ; Heidbüchel, Hein ; Kautzner, Josef ; Kim, June Soo ; Lanas, Fernando ; Lewis, Basil S. ; Merino, Jose L. ; Morillo, Carlos ; Murin, Jan ; Narasimhan, Calambur ; Paolasso, Ernesto ; Parkhomenko, Alexander ; Peters, Nicholas S. ; Sim, Kui Hian ; Stiles, Martin K. ; Tanomsup, Supachai ; Toivonen, Lauri ; Tomcsányi, János ; Torp-Pedersen, Christian ; Tse, Hung Fat ; Vardas, Panos ; Vinereanu, Dragos ; Xavier, Denis ; Zhu, Jun ; Zhu, Jun Ren ; Baret-Cormel, Lydie ; Weinling, Estelle ; Staiger, Christoph ; Yusuf, Salim ; Chrolavicius, Susan ; Afzal, Rizwan ; Hohnloser, Stefan H. ; Wyse, D. G. ; Cairns, J. ; Pfeffer, M. ; Pocock, S. ; Wellens, H. ; Atra, M. ; Basart, D. C. ; Bornstein, N. M. ; Brandes, A. ; De Raedt, H. ; Doiny, D. ; Duray, G. Z. ; Dvorakova, H. ; Estrada, A. ; Fodor, G. ; Gross, B. ; Halon, D. ; Häppölä, O. ; Hart, R. ; Healey, J. S. ; Jacobsson, F. ; Kalvach, P. ; Krahn, A. ; Laine, M. ; Maggioni, A. P. ; Mairesse, G. H. ; Muir, S. W. ; Norrving, B. ; Peeters, A. ; Pizzolato, G. ; Ruiz-Ares, G. ; Veltmann, C. ; Verdecchia, P. ; Widimsky, P. ; Zaborski, J. ; Zimlichman, R. ; Demaerschalk, B. ; Diener, H. C. ; Tirschwell, D. ; Holmes, E. ; Lawrence, M. ; Bajkor, S. ; McCready, T. ; Meeks, B. ; Gao, P. ; Smith, J. ; Yang, X. ; Yuan, F. ; Blake, L. ; Dunlop, V. ; Gasic, Z. ; Molnar, S. ; Nieuwlaat, R. ; Pasadyn, E. ; Sephton, J. ; Tuhy, R. ; Wild, M. ; Caccavo, A. ; Cartasegna, L. R. ; Cuneo, C. A. ; Garrido, M. A. ; Guzman, L. A. ; Hominal, M. A. ; Llanos, J. R. ; MacKinnon, I. J. ; Vico, M. L. ; Vogel, D. R. ; Zaidman, C. J. ; Colquhoun, D. ; Counsell, J. T. ; de Looze, F. J. ; Durbidge, V. K. ; Purnell, P. W. ; Soward, A. L. ; van Gaal, W. J. ; William, M. ; Burkart-Kuettner, D. ; Huber, K. ; Pieske, B. ; Roithinger, F. X. ; Catez, E. M. ; Cools, F. J. ; De Roy, L. ; De Vusser, P. ; De Wolf, L. ; Deceuninck, O. ; Dilling-Boer, D. ; Goethals, M. P. ; Paparella, G. ; Provenier, F. ; Scavée, C. ; Vervoort, G. ; Botelho, R. V. ; Braga, J. S. ; de Paola, A. A. ; de Souza, W. K. ; Genta, P. R. ; Hernandes, M. E. ; Jaber, J. ; Lorga-Filho, A. M. ; Manenti, E. R. ; Jorge, J. C. ; Précoma, D. B. ; Reis, G. ; Rossi, P. R. ; Sousa, A. C. ; Zimmermann, S. L. ; Gronkova, N. I. ; Tumbev, H. S. ; Bose, S. ; Boucher, P. ; Cha, J. Y. ; Constance, C. M. ; Costi, P. ; Coutu, B. ; Gupta, M. ; Kouz, S. ; Lam, A. S. ; Leather, R. ; Pandey, A. S. ; Rebane, T. ; Savard, D. ; St-Hilaire, R. ; Vizel, S. ; Cobos, J. L. ; Corbalan, R. ; Donoso, H. ; Escobar, E. ; Medina, M. E. ; Potthoff, S. H. ; Raffo, C. A. ; Saavedra, J. G. ; Tijerino, M. A. ; Ballek, L. ; Boček, P. ; Choura, M. ; Dědek, V. ; Egert, A. ; Hudcovic, M. ; Klimsa, Z. ; Labrova, R. ; Malecha, J. ; Petrova, I. ; Podpera, I. ; Poklopová, Z. ; Velimsky, T. ; Dixen, U. ; Egstrup, K. ; Frost, L. ; Gislason, G. ; Husted, S. E. ; Jakobsen, T. J. ; Jeppesen, J. ; Kaae Dodt, K. ; Klarlund, K. K. ; Melchior, T. M. ; Nielsen, H. ; Skagen, K. ; Aro, A. ; Huikuri, H. V. ; Kyto, V. ; Nyman, K. ; Utriainen, S. ; Ylitalo, A. ; Fouche, R. ; Gacem, K. ; Mansour, M. ; Pasquie, J. L. ; Poulard, J. E. ; Appel, K. F. ; Axthelm, C. ; Bosch, R. F. ; Bushoven, P. ; Darius, H. ; Grönefeld, G. C. ; Hanefeld, C. ; Haverkamp, W. ; Horacek, T. ; Israel, C. W. ; Killat, H. ; Klingenheben, T. ; Kreuzer, J. ; Leicht, M. ; Licka, M. B. ; Niethammer, M. ; Rieker, W. A. ; Salbach, P. ; Schenkenberger, I. ; Schmidt, A. ; Spitzer, S. G. ; Toursarkissian, N. ; Veltkamp, R. ; Weissbrodt, M. ; Winkelmann, B. R. ; Wurziger, J. ; Zemmrich, C. ; Vogiatzis, I. A. ; Siu, C. W. ; Ferencz, G. ; Katona, A. ; Keltai, K. ; Kovács, Z. ; Laszlo, Z. ; Poor, F. ; Szakal, I. ; Toldy-Schedel, E. ; Vertes, A. ; Eldar, M. ; Elias, M. ; Freedberg, N. A. ; Halabi, S. ; Hamoud, S. ; Katz, A. ; Klainman, E. E. ; Marmor, A. ; Medina, A. ; Mosseri, M. ; Motro, M. ; Stein, G. Y. ; Weiss, T. ; Zeltser, D. ; Calabrese, D. ; Cosmi, F. ; de Tommasi, F. ; Glorioso, N. ; Gulizia, M. M. ; Mennuni, M. ; Piovaccari, G. ; Chee, K. H. ; Alcocer Gamba, M. A. ; Alvarado-Ruiz, R. ; Arenas, J. L. ; Bayram Llamas, E. ; Calvo Vargas, C. G. ; Carrillo, J. ; Fernandez-Bonetti, P. ; Gomez, J. F. ; Llamas-Esperón, G. ; Lopez Rosas, E. ; Matadamas Hernandez, N. ; Ramirez Isunza, J. M. ; Salcido, E. ; Velasco-Sanchez, R. G. ; Bartels, G. L. ; Bracke, F. ; Bruning, T. A. ; Cozijnsen, L. ; de Weerd, G. J. ; den Hartog, F. R. ; Geertman, H. ; Hamraoui, K. ; Heesen, W. F. ; Hunze, I. ; Idzerda, H. H. ; Kragten, J. ; Liem, A. H. ; Lok, D. J. ; Moens, A. ; Plomp, J. ; Pos, L. ; Ramdat Misier, A. R. ; Remmen, J. J. ; Ruiter, J. H. ; Scholten, M. F. ; Swart, H. P. ; Tans, J. G. ; Theunissen, L. ; Tukkie, R. ; van der Heijden, R. ; Van Doorn, D. J. ; Van Gelder, I. C. ; van Hessen, M. W. ; Westendorp, P. H. ; Willems, A. R. ; Zoet-Nugteren, S. K. ; Aitken, S. A. ; Elliott, J. M. ; Scales, J. E. ; Scott, B. ; Ternouth, I. F. ; Tisch, J. ; Berg-Johansen, J. ; Husvik, M. A. ; Istad, H. ; Risberg, K. ; Rød, R. ; Sirnes, P. A. ; Skjelvan, G. K. ; Bednarski, J. ; Bronisz, M. ; Bryniarski, L. ; Gniot, J. R. ; Kawka-Urbanek, T. ; Kopaczewski, J. ; Miekus, P. ; Pasierski, T. J. ; Piepiorka, M. ; Prochaczek, F. ; Raczak, G. ; Rekosz, J. ; Stepinska, J. ; Szelemej, R. ; Szpajer, M. ; Zaborska, B. ; Cinteza, M. A. ; Ciobanu, A. O. ; Dan, A. R. ; Dimulescu, D. ; Fierbinteanu-Braticevici, C. G. ; Istratoaie, O. ; Lighezan, D. F. ; Minescu, B. ; Vintila, M. M. ; Akhmedzhanov, N. M. ; Alikhanov, B. A. ; Barabashkina, A. V. ; Barbarash, O. ; Barbarich, V. B. ; Bart, B. Y. ; Boyarkin, M. V. ; Burova, N. N. ; Bychkova, L. ; Fitilev, S. B. ; Gizatulina, T. P. ; Khaisheva, L. A. ; Konstantinov, V. O. ; Koziolova, N. ; Lesnov, V. ; Lukyanov, Y. ; Lyamina, N. P. ; Malkina, T. A. ; Miller, O. N. ; Moiseev, V. ; Novikova, N. V. ; Orlikova, O. V. ; Orlov, V. A. ; Osipenko, M. F. ; Panchenko, E. ; Platonov, D. Y. ; Popov, S. V. ; Rafalakiy, V. V. ; Ruda, M. Y. ; Seliverstova, S. A. ; Shalaev, S. V. ; Shchekotov, V. V. ; Shubik, Y. ; Shvarts, Y. ; Sulimov, V. A. ; Tretyakova, T. V. ; Vaniev, S. ; Vishnevsky, A. ; Yakusevich, V. V. ; Yakushin, S. S. ; Zrazhevskiy, K. N. ; Teo, W. S. ; Bugan, V. ; Kaliská, G. ; Masarovičová, M. ; Nociar, J. ; Pella, D. ; Uhliar, R. ; Bushidi, M. ; Engelbrecht, J. M. ; Okreglicki, A. M. ; Pillay, T. ; Snyders, F. A. ; Theron, H. D. ; Venter, T. P. ; Cho, J. G. ; Kim, D. ; Kim, Y. H. ; Lee, M. H. ; Oh, S. ; On, Y. K. ; Rho, T. H. ; Shin, D. H. ; Alzueta, J. ; Bruguera, J. ; Castrejon, S. ; Díaz-Infante, E. ; Grigorian Shamagian, L. ; Martínez-Rubio, A. ; Mont, L. ; Vida, M. ; Viñolas, X. ; Berglund, S. T. ; Blomstrom-Lundqvist, C. ; Cherfan, P. ; Jakobsson, S. ; Johansson, L. ; Juhlin, T. ; Kozak, P. ; Rönn, F. ; Rosenqvist, M. ; Sprock, L. ; Gallino, A. F. ; Lyrer, P. A. ; Moccetti, T. ; Chen, M. C. ; Hu, Y. F. ; Lin, J. L. ; Wen, M. S. ; Karpenko, O. I. ; Kozhukhov, S. ; Kraiz, I. ; Pavlyk, S. S. ; Potapenko, P. I. ; Prokhorov, O. V. ; Prudkyi, I. V. ; Prykhodko, V. Y. ; Rudenko, L. V. ; Sychov, O. S. ; Tseluyko, V. I. ; Vizir, V. A. ; Zharinov, O. J. ; Aggarwal, R. ; Copley, A. J. ; Davey, P. P. ; Kadr, H. H. ; Lip, G. Y. ; Lord, S. ; Moriarty, A. J. ; Pye, M. P. ; Ryding, A. D. ; Savelieva, I. ; Abadier, R. ; Ahmad, S. ; Ahmad, Z. M. ; Alexander, K. P. ; Alfieri, A. D. ; Baker, S. ; Ball, E. M. ; Baruch, L. ; Bellam, R. P. ; Benjamin, S. A. ; Brill, D. A. ; Browne, K. F. ; Call, J. T. ; Carr, K. W. ; Chandna, H. ; Chen, C. ; Chen, Y. C. ; Chilakapati, V. S. ; Colan, D. ; Cossu, S. F. ; Dean, J. ; DeFehr, S. P. ; Dempsey, S. J. ; Desai, V. S. ; Dohrmann, M. L. ; Ellison, H. S. ; Emlein, G. ; Farris, N. ; Fields, R. H. ; Fishbein, G. J. ; Flores, E. A. ; Friedlander, I. R. ; Gelernt, M. D. ; Genovely, H. C. ; Gillespie, E. L. ; Go, B. M. ; Gottlieb, D. W. ; Grena, P. G. ; Guarnieri, T. ; Gupta, D. K. ; Haidar, A. A. ; Hamroff, G. S. ; Hargrove, J. L. ; Haskel, E. J. ; Hearne, S. E. ; Henderson, D. A. ; Herre, J. M. ; Herzog, W. R. ; Hoppe, B. L. ; Hotchkiss, D. ; Humiston, D. J. ; Igic, P. G. ; Jackson, B. K. ; Jacobson, A. K. ; Jaffrani, N. A. ; Jarzabkowski, D. ; Jazayeri, M. R. ; Kaplan, A. J. ; Khant, R. N. ; Kim, A. C. ; Klancke, K. A. ; Kosinski, E. J. ; Kovach, M. ; Kramer, J. H. ; Lader, E. W. ; LeLevier, J. A. ; Lepor, N. E. ; Levy, R. M. ; Littlefield, R. H. ; Marple, R. N. ; McGrew, F. A. ; McWilliams, M. J. ; Meholick, A. ; Mirro, M. J. ; Murphy, J. F. ; Murray, A. V. ; Nadar, V. K. ; Nanna, M. ; Navarrete-Casas, A. J. ; O'Dea, D. J. ; O'Neill, P. G. ; Oza, S. R. ; Patel, R. J. ; Perlmutter, N. S. ; Pierce, D. L. ; Promisloff, S. D. ; Pulido, J. G. ; Rahman, J. ; Rhodes, D. V. ; Rubin, A. M. ; Sandberg, J. H. ; Sandesara, C. M. ; Schreiman, R. ; Shah, A. ; Sheikh, K. H. ; Singh, N. ; Sloan, S. B. ; Sofley, C. W. ; Staniloae, C. S. ; Teixeira, J. M. ; Tuan, W. M. ; Vaid, B. R. ; Vicari, R. M. ; Vijay, N. K. ; Vora, K. N. ; Weiss, R. J. ; Wenocur, H. S. ; Yunus, A. / Dronedarone in high-risk permanent atrial fibrillation. In: New England Journal of Medicine. 2011 ; Vol. 365, No. 24. pp. 2268-2276.

BibTeX

@article{c77f6120e760491e896640034b742808,

title = "Dronedarone in high-risk permanent atrial fibrillation",

abstract = "BACKGROUND: Dronedarone restores sinus rhythm and reduces hospitalization or death in intermittent atrial fibrillation. It also lowers heart rate and blood pressure and has antiadrenergic and potential ventricular antiarrhythmic effects. We hypothesized that dronedarone would reduce major vascular events in high-risk permanent atrial fibrillation. METHODS: We assigned patients who were at least 65 years of age with at least a 6-month history of permanent atrial fibrillation and risk factors for major vascular events to receive dronedarone or placebo. The first coprimary outcome was stroke, myocardial infarction, systemic embolism, or death from cardiovascular causes. The second coprimary outcome was unplanned hospitalization for a cardiovascular cause or death. RESULTS: After the enrollment of 3236 patients, the study was stopped for safety reasons. The first coprimary outcome occurred in 43 patients receiving dronedarone and 19 receiving placebo (hazard ratio, 2.29; 95% confidence interval [CI], 1.34 to 3.94; P = 0.002). There were 21 deaths from cardiovascular causes in the dronedarone group and 10 in the placebo group (hazard ratio, 2.11; 95% CI, 1.00 to 4.49; P = 0.046), including death from arrhythmia in 13 patients and 4 patients, respectively (hazard ratio, 3.26; 95% CI, 1.06 to 10.00; P = 0.03). Stroke occurred in 23 patients in the dronedarone group and 10 in the placebo group (hazard ratio, 2.32; 95% CI, 1.11 to 4.88; P = 0.02). Hospitalization for heart failure occurred in 43 patients in the dronedarone group and 24 in the placebo group (hazard ratio, 1.81; 95% CI, 1.10 to 2.99; P = 0.02). CONCLUSIONS: Dronedarone increased rates of heart failure, stroke, and death from cardiovascular causes in patients with permanent atrial fibrillation who were at risk for major vascular events. Our data show that this drug should not be used in such patients. (Funded by Sanofi-Aventis; PALLAS ClinicalTrials.gov number, NCT01151137.)",

author = "Connolly, {Stuart J.} and Camm, {A. John} and Halperin, {Jonathan L.} and Campbell Joyner and Marco Alings and John Amerena and Dan Atar and {\'A}lvaro Avezum and Per Blomstr{\"o}m and Martin Borggrefe and Andrzej Budaj and Chen, {Shih Ann} and Ching, {Chi Keong} and Patrick Commerford and Antonio Dans and Davy, {Jean Marc} and Etienne Delacr{\'e}taz and {Di Pasquale}, Giuseppe and Rafael Diaz and Paul Dorian and Greg Flaker and Sergey Golitsyn and Antonio Gonzalez-Hermosillo and Granger, {Christopher B.} and Hein Heidb{\"u}chel and Josef Kautzner and Kim, {June Soo} and Fernando Lanas and Lewis, {Basil S.} and Merino, {Jose L.} and Carlos Morillo and Jan Murin and Calambur Narasimhan and Ernesto Paolasso and Alexander Parkhomenko and Peters, {Nicholas S.} and Sim, {Kui Hian} and Stiles, {Martin K.} and Supachai Tanomsup and Lauri Toivonen and J{\'a}nos Tomcs{\'a}nyi and Christian Torp-Pedersen and Tse, {Hung Fat} and Panos Vardas and Dragos Vinereanu and Denis Xavier and Jun Zhu and Zhu, {Jun Ren} and Lydie Baret-Cormel and Estelle Weinling and Christoph Staiger and Salim Yusuf and Susan Chrolavicius and Rizwan Afzal and Hohnloser, {Stefan H.} and Wyse, {D. G.} and J. Cairns and M. Pfeffer and S. Pocock and H. Wellens and M. Atra and Basart, {D. C.} and Bornstein, {N. M.} and A. Brandes and {De Raedt}, H. and D. Doiny and Duray, {G. Z.} and H. Dvorakova and A. Estrada and G. Fodor and B. Gross and D. Halon and O. H{\"a}pp{\"o}l{\"a} and R. Hart and Healey, {J. S.} and F. Jacobsson and P. Kalvach and A. Krahn and M. Laine and Maggioni, {A. P.} and Mairesse, {G. H.} and Muir, {S. W.} and B. Norrving and A. Peeters and G. Pizzolato and G. Ruiz-Ares and C. Veltmann and P. Verdecchia and P. Widimsky and J. Zaborski and R. Zimlichman and B. Demaerschalk and Diener, {H. C.} and D. Tirschwell and E. Holmes and M. Lawrence and S. Bajkor and T. McCready and B. Meeks and P. Gao and J. Smith and X. Yang and F. Yuan and L. Blake and V. Dunlop and Z. Gasic and S. Molnar and R. Nieuwlaat and E. Pasadyn and J. Sephton and R. Tuhy and M. Wild and A. Caccavo and Cartasegna, {L. R.} and Cuneo, {C. A.} and Garrido, {M. A.} and Guzman, {L. A.} and Hominal, {M. A.} and Llanos, {J. R.} and MacKinnon, {I. J.} and Vico, {M. L.} and Vogel, {D. R.} and Zaidman, {C. J.} and D. Colquhoun and Counsell, {J. T.} and {de Looze}, {F. J.} and Durbidge, {V. K.} and Purnell, {P. W.} and Soward, {A. L.} and {van Gaal}, {W. J.} and M. William and D. Burkart-Kuettner and K. Huber and B. Pieske and Roithinger, {F. X.} and Catez, {E. M.} and Cools, {F. J.} and {De Roy}, L. and {De Vusser}, P. and {De Wolf}, L. and O. Deceuninck and D. Dilling-Boer and Goethals, {M. P.} and G. Paparella and F. Provenier and C. Scav{\'e}e and G. Vervoort and Botelho, {R. V.} and Braga, {J. S.} and {de Paola}, {A. A.} and {de Souza}, {W. K.} and Genta, {P. R.} and Hernandes, {M. E.} and J. Jaber and Lorga-Filho, {A. M.} and Manenti, {E. R.} and Jorge, {J. C.} and Pr{\'e}coma, {D. B.} and G. Reis and Rossi, {P. R.} and Sousa, {A. C.} and Zimmermann, {S. L.} and Gronkova, {N. I.} and Tumbev, {H. S.} and S. Bose and P. Boucher and Cha, {J. Y.} and Constance, {C. M.} and P. Costi and B. Coutu and M. Gupta and S. Kouz and Lam, {A. S.} and R. Leather and Pandey, {A. S.} and T. Rebane and D. Savard and R. St-Hilaire and S. Vizel and Cobos, {J. L.} and R. Corbalan and H. Donoso and E. Escobar and Medina, {M. E.} and Potthoff, {S. H.} and Raffo, {C. A.} and Saavedra, {J. G.} and Tijerino, {M. A.} and L. Ballek and P. Bo{\v c}ek and M. Choura and V. D{\v e}dek and A. Egert and M. Hudcovic and Z. Klimsa and R. Labrova and J. Malecha and I. Petrova and I. Podpera and Z. Poklopov{\'a} and T. Velimsky and U. Dixen and K. Egstrup and L. Frost and G. Gislason and Husted, {S. E.} and Jakobsen, {T. J.} and J. Jeppesen and {Kaae Dodt}, K. and Klarlund, {K. K.} and Melchior, {T. M.} and H. Nielsen and K. Skagen and A. Aro and Huikuri, {H. V.} and V. Kyto and K. Nyman and S. Utriainen and A. Ylitalo and R. Fouche and K. Gacem and M. Mansour and Pasquie, {J. L.} and Poulard, {J. E.} and Appel, {K. F.} and C. Axthelm and Bosch, {R. F.} and P. Bushoven and H. Darius and Gr{\"o}nefeld, {G. C.} and C. Hanefeld and W. Haverkamp and T. Horacek and Israel, {C. W.} and H. Killat and T. Klingenheben and J. Kreuzer and M. Leicht and Licka, {M. B.} and M. Niethammer and Rieker, {W. A.} and P. Salbach and I. Schenkenberger and A. Schmidt and Spitzer, {S. G.} and N. Toursarkissian and R. Veltkamp and M. Weissbrodt and Winkelmann, {B. R.} and J. Wurziger and C. Zemmrich and Vogiatzis, {I. A.} and Siu, {C. W.} and G. Ferencz and A. Katona and K. Keltai and Z. Kov{\'a}cs and Z. Laszlo and F. Poor and I. Szakal and E. Toldy-Schedel and A. Vertes and M. Eldar and M. Elias and Freedberg, {N. A.} and S. Halabi and S. Hamoud and A. Katz and Klainman, {E. E.} and A. Marmor and A. Medina and M. Mosseri and M. Motro and Stein, {G. Y.} and T. Weiss and D. Zeltser and D. Calabrese and F. Cosmi and {de Tommasi}, F. and N. Glorioso and Gulizia, {M. M.} and M. Mennuni and G. Piovaccari and Chee, {K. H.} and {Alcocer Gamba}, {M. A.} and R. Alvarado-Ruiz and Arenas, {J. L.} and {Bayram Llamas}, E. and {Calvo Vargas}, {C. G.} and J. Carrillo and P. Fernandez-Bonetti and Gomez, {J. F.} and G. Llamas-Esper{\'o}n and {Lopez Rosas}, E. and {Matadamas Hernandez}, N. and {Ramirez Isunza}, {J. M.} and E. Salcido and Velasco-Sanchez, {R. G.} and Bartels, {G. L.} and F. Bracke and Bruning, {T. A.} and L. Cozijnsen and {de Weerd}, {G. J.} and {den Hartog}, {F. R.} and H. Geertman and K. Hamraoui and Heesen, {W. F.} and I. Hunze and Idzerda, {H. H.} and J. Kragten and Liem, {A. H.} and Lok, {D. J.} and A. Moens and J. Plomp and L. Pos and {Ramdat Misier}, {A. R.} and Remmen, {J. J.} and Ruiter, {J. H.} and Scholten, {M. F.} and Swart, {H. P.} and Tans, {J. G.} and L. Theunissen and R. Tukkie and {van der Heijden}, R. and {Van Doorn}, {D. J.} and {Van Gelder}, {I. C.} and {van Hessen}, {M. W.} and Westendorp, {P. H.} and Willems, {A. R.} and Zoet-Nugteren, {S. K.} and Aitken, {S. A.} and Elliott, {J. M.} and Scales, {J. E.} and B. Scott and Ternouth, {I. F.} and J. Tisch and J. Berg-Johansen and Husvik, {M. A.} and H. Istad and K. Risberg and R. R{\o}d and Sirnes, {P. A.} and Skjelvan, {G. K.} and J. Bednarski and M. Bronisz and L. Bryniarski and Gniot, {J. R.} and T. Kawka-Urbanek and J. Kopaczewski and P. Miekus and Pasierski, {T. J.} and M. Piepiorka and F. Prochaczek and G. Raczak and J. Rekosz and J. Stepinska and R. Szelemej and M. Szpajer and B. Zaborska and Cinteza, {M. A.} and Ciobanu, {A. O.} and Dan, {A. R.} and D. Dimulescu and Fierbinteanu-Braticevici, {C. G.} and O. Istratoaie and Lighezan, {D. F.} and B. Minescu and Vintila, {M. M.} and Akhmedzhanov, {N. M.} and Alikhanov, {B. A.} and Barabashkina, {A. V.} and O. Barbarash and Barbarich, {V. B.} and Bart, {B. Y.} and Boyarkin, {M. V.} and Burova, {N. N.} and L. Bychkova and Fitilev, {S. B.} and Gizatulina, {T. P.} and Khaisheva, {L. A.} and Konstantinov, {V. O.} and N. Koziolova and V. Lesnov and Y. Lukyanov and Lyamina, {N. P.} and Malkina, {T. A.} and Miller, {O. N.} and V. Moiseev and Novikova, {N. V.} and Orlikova, {O. V.} and Orlov, {V. A.} and Osipenko, {M. F.} and E. Panchenko and Platonov, {D. Y.} and Popov, {S. V.} and Rafalakiy, {V. V.} and Ruda, {M. Y.} and Seliverstova, {S. A.} and Shalaev, {S. V.} and Shchekotov, {V. V.} and Y. Shubik and Y. Shvarts and Sulimov, {V. A.} and Tretyakova, {T. V.} and S. Vaniev and A. Vishnevsky and Yakusevich, {V. V.} and Yakushin, {S. S.} and Zrazhevskiy, {K. N.} and Teo, {W. S.} and V. Bugan and G. Kalisk{\'a} and M. Masarovi{\v c}ov{\'a} and J. Nociar and D. Pella and R. Uhliar and M. Bushidi and Engelbrecht, {J. M.} and Okreglicki, {A. M.} and T. Pillay and Snyders, {F. A.} and Theron, {H. D.} and Venter, {T. P.} and Cho, {J. G.} and D. Kim and Kim, {Y. H.} and Lee, {M. H.} and S. Oh and On, {Y. K.} and Rho, {T. H.} and Shin, {D. H.} and J. Alzueta and J. Bruguera and S. Castrejon and E. D{\'i}az-Infante and {Grigorian Shamagian}, L. and A. Mart{\'i}nez-Rubio and L. Mont and M. Vida and X. Vi{\~n}olas and Berglund, {S. T.} and C. Blomstrom-Lundqvist and P. Cherfan and S. Jakobsson and L. Johansson and T. Juhlin and P. Kozak and F. R{\"o}nn and M. Rosenqvist and L. Sprock and Gallino, {A. F.} and Lyrer, {P. A.} and T. Moccetti and Chen, {M. C.} and Hu, {Y. F.} and Lin, {J. L.} and Wen, {M. S.} and Karpenko, {O. I.} and S. Kozhukhov and I. Kraiz and Pavlyk, {S. S.} and Potapenko, {P. I.} and Prokhorov, {O. V.} and Prudkyi, {I. V.} and Prykhodko, {V. Y.} and Rudenko, {L. V.} and Sychov, {O. S.} and Tseluyko, {V. I.} and Vizir, {V. A.} and Zharinov, {O. J.} and R. Aggarwal and Copley, {A. J.} and Davey, {P. P.} and Kadr, {H. H.} and Lip, {G. Y.} and S. Lord and Moriarty, {A. J.} and Pye, {M. P.} and Ryding, {A. D.} and I. Savelieva and R. Abadier and S. Ahmad and Ahmad, {Z. M.} and Alexander, {K. P.} and Alfieri, {A. D.} and S. Baker and Ball, {E. M.} and L. Baruch and Bellam, {R. P.} and Benjamin, {S. A.} and Brill, {D. A.} and Browne, {K. F.} and Call, {J. T.} and Carr, {K. W.} and H. Chandna and C. Chen and Chen, {Y. C.} and Chilakapati, {V. S.} and D. Colan and Cossu, {S. F.} and J. Dean and DeFehr, {S. P.} and Dempsey, {S. J.} and Desai, {V. S.} and Dohrmann, {M. L.} and Ellison, {H. S.} and G. Emlein and N. Farris and Fields, {R. H.} and Fishbein, {G. J.} and Flores, {E. A.} and Friedlander, {I. R.} and Gelernt, {M. D.} and Genovely, {H. C.} and Gillespie, {E. L.} and Go, {B. M.} and Gottlieb, {D. W.} and Grena, {P. G.} and T. Guarnieri and Gupta, {D. K.} and Haidar, {A. A.} and Hamroff, {G. S.} and Hargrove, {J. L.} and Haskel, {E. J.} and Hearne, {S. E.} and Henderson, {D. A.} and Herre, {J. M.} and Herzog, {W. R.} and Hoppe, {B. L.} and D. Hotchkiss and Humiston, {D. J.} and Igic, {P. G.} and Jackson, {B. K.} and Jacobson, {A. K.} and Jaffrani, {N. A.} and D. Jarzabkowski and Jazayeri, {M. R.} and Kaplan, {A. J.} and Khant, {R. N.} and Kim, {A. C.} and Klancke, {K. A.} and Kosinski, {E. J.} and M. Kovach and Kramer, {J. H.} and Lader, {E. W.} and LeLevier, {J. A.} and Lepor, {N. E.} and Levy, {R. M.} and Littlefield, {R. H.} and Marple, {R. N.} and McGrew, {F. A.} and McWilliams, {M. J.} and A. Meholick and Mirro, {M. J.} and Murphy, {J. F.} and Murray, {A. V.} and Nadar, {V. K.} and M. Nanna and Navarrete-Casas, {A. J.} and O'Dea, {D. J.} and O'Neill, {P. G.} and Oza, {S. R.} and Patel, {R. J.} and Perlmutter, {N. S.} and Pierce, {D. L.} and Promisloff, {S. D.} and Pulido, {J. G.} and J. Rahman and Rhodes, {D. V.} and Rubin, {A. M.} and Sandberg, {J. H.} and Sandesara, {C. M.} and R. Schreiman and A. Shah and Sheikh, {K. H.} and N. Singh and Sloan, {S. B.} and Sofley, {C. W.} and Staniloae, {C. S.} and Teixeira, {J. M.} and Tuan, {W. M.} and Vaid, {B. R.} and Vicari, {R. M.} and Vijay, {N. K.} and Vora, {K. N.} and Weiss, {R. J.} and Wenocur, {H. S.} and A. Yunus",

year = "2011",

month = dec,

day = "15",

doi = "10.1056/NEJMoa1109867",

language = "English",

volume = "365",

pages = "2268--2276",

journal = "New England Journal of Medicine",

issn = "0028-4793",

publisher = "Massachussetts Medical Society",

number = "24",

}

RIS

TY - JOUR

T1 - Dronedarone in high-risk permanent atrial fibrillation

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AU - Friedlander, I. R.

AU - Gelernt, M. D.

AU - Genovely, H. C.

AU - Gillespie, E. L.

AU - Go, B. M.

AU - Gottlieb, D. W.

AU - Grena, P. G.

AU - Guarnieri, T.

AU - Gupta, D. K.

AU - Haidar, A. A.

AU - Hamroff, G. S.

AU - Hargrove, J. L.

AU - Haskel, E. J.

AU - Hearne, S. E.

AU - Henderson, D. A.

AU - Herre, J. M.

AU - Herzog, W. R.

AU - Hoppe, B. L.

AU - Hotchkiss, D.

AU - Humiston, D. J.

AU - Igic, P. G.

AU - Jackson, B. K.

AU - Jacobson, A. K.

AU - Jaffrani, N. A.

AU - Jarzabkowski, D.

AU - Jazayeri, M. R.

AU - Kaplan, A. J.

AU - Khant, R. N.

AU - Kim, A. C.

AU - Klancke, K. A.

AU - Kosinski, E. J.

AU - Kovach, M.

AU - Kramer, J. H.

AU - Lader, E. W.

AU - LeLevier, J. A.

AU - Lepor, N. E.

AU - Levy, R. M.

AU - Littlefield, R. H.

AU - Marple, R. N.

AU - McGrew, F. A.

AU - McWilliams, M. J.

AU - Meholick, A.

AU - Mirro, M. J.

AU - Murphy, J. F.

AU - Murray, A. V.

AU - Nadar, V. K.

AU - Nanna, M.

AU - Navarrete-Casas, A. J.

AU - O'Dea, D. J.

AU - O'Neill, P. G.

AU - Oza, S. R.

AU - Patel, R. J.

AU - Perlmutter, N. S.

AU - Pierce, D. L.

AU - Promisloff, S. D.

AU - Pulido, J. G.

AU - Rahman, J.

AU - Rhodes, D. V.

AU - Rubin, A. M.

AU - Sandberg, J. H.

AU - Sandesara, C. M.

AU - Schreiman, R.

AU - Shah, A.

AU - Sheikh, K. H.

AU - Singh, N.

AU - Sloan, S. B.

AU - Sofley, C. W.

AU - Staniloae, C. S.

AU - Teixeira, J. M.

AU - Tuan, W. M.

AU - Vaid, B. R.

AU - Vicari, R. M.

AU - Vijay, N. K.

AU - Vora, K. N.

AU - Weiss, R. J.

AU - Wenocur, H. S.

AU - Yunus, A.

PY - 2011/12/15

Y1 - 2011/12/15

N2 - BACKGROUND: Dronedarone restores sinus rhythm and reduces hospitalization or death in intermittent atrial fibrillation. It also lowers heart rate and blood pressure and has antiadrenergic and potential ventricular antiarrhythmic effects. We hypothesized that dronedarone would reduce major vascular events in high-risk permanent atrial fibrillation. METHODS: We assigned patients who were at least 65 years of age with at least a 6-month history of permanent atrial fibrillation and risk factors for major vascular events to receive dronedarone or placebo. The first coprimary outcome was stroke, myocardial infarction, systemic embolism, or death from cardiovascular causes. The second coprimary outcome was unplanned hospitalization for a cardiovascular cause or death. RESULTS: After the enrollment of 3236 patients, the study was stopped for safety reasons. The first coprimary outcome occurred in 43 patients receiving dronedarone and 19 receiving placebo (hazard ratio, 2.29; 95% confidence interval [CI], 1.34 to 3.94; P = 0.002). There were 21 deaths from cardiovascular causes in the dronedarone group and 10 in the placebo group (hazard ratio, 2.11; 95% CI, 1.00 to 4.49; P = 0.046), including death from arrhythmia in 13 patients and 4 patients, respectively (hazard ratio, 3.26; 95% CI, 1.06 to 10.00; P = 0.03). Stroke occurred in 23 patients in the dronedarone group and 10 in the placebo group (hazard ratio, 2.32; 95% CI, 1.11 to 4.88; P = 0.02). Hospitalization for heart failure occurred in 43 patients in the dronedarone group and 24 in the placebo group (hazard ratio, 1.81; 95% CI, 1.10 to 2.99; P = 0.02). CONCLUSIONS: Dronedarone increased rates of heart failure, stroke, and death from cardiovascular causes in patients with permanent atrial fibrillation who were at risk for major vascular events. Our data show that this drug should not be used in such patients. (Funded by Sanofi-Aventis; PALLAS ClinicalTrials.gov number, NCT01151137.)

AB - BACKGROUND: Dronedarone restores sinus rhythm and reduces hospitalization or death in intermittent atrial fibrillation. It also lowers heart rate and blood pressure and has antiadrenergic and potential ventricular antiarrhythmic effects. We hypothesized that dronedarone would reduce major vascular events in high-risk permanent atrial fibrillation. METHODS: We assigned patients who were at least 65 years of age with at least a 6-month history of permanent atrial fibrillation and risk factors for major vascular events to receive dronedarone or placebo. The first coprimary outcome was stroke, myocardial infarction, systemic embolism, or death from cardiovascular causes. The second coprimary outcome was unplanned hospitalization for a cardiovascular cause or death. RESULTS: After the enrollment of 3236 patients, the study was stopped for safety reasons. The first coprimary outcome occurred in 43 patients receiving dronedarone and 19 receiving placebo (hazard ratio, 2.29; 95% confidence interval [CI], 1.34 to 3.94; P = 0.002). There were 21 deaths from cardiovascular causes in the dronedarone group and 10 in the placebo group (hazard ratio, 2.11; 95% CI, 1.00 to 4.49; P = 0.046), including death from arrhythmia in 13 patients and 4 patients, respectively (hazard ratio, 3.26; 95% CI, 1.06 to 10.00; P = 0.03). Stroke occurred in 23 patients in the dronedarone group and 10 in the placebo group (hazard ratio, 2.32; 95% CI, 1.11 to 4.88; P = 0.02). Hospitalization for heart failure occurred in 43 patients in the dronedarone group and 24 in the placebo group (hazard ratio, 1.81; 95% CI, 1.10 to 2.99; P = 0.02). CONCLUSIONS: Dronedarone increased rates of heart failure, stroke, and death from cardiovascular causes in patients with permanent atrial fibrillation who were at risk for major vascular events. Our data show that this drug should not be used in such patients. (Funded by Sanofi-Aventis; PALLAS ClinicalTrials.gov number, NCT01151137.)

UR - http://www.scopus.com/inward/record.url?scp=84855163167&partnerID=8YFLogxK

U2 - 10.1056/NEJMoa1109867

DO - 10.1056/NEJMoa1109867

M3 - Article

C2 - 22082198

VL - 365

SP - 2268

EP - 2276

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 24

ER -

ID: 8173071