Does the membrane pacemaker theory of metabolism explain the size dependence of metabolic rate in marine mussels?

Standard

Does the membrane pacemaker theory of metabolism explain the size dependence of metabolic rate in marine mussels? / Sukhotin, Alexey; Fokina, Natalia; Ruokolainen, Tatiana; Bock, Christian; Pörtner, Hans Otto; Lannig, Gisela.

In: Journal of Experimental Biology, Vol. 220, No. 8, 15.04.2017, p. 1423-1434.

Research output: Contribution to journal › Article › peer-review

Author

Sukhotin, Alexey ; Fokina, Natalia ; Ruokolainen, Tatiana ; Bock, Christian ; Pörtner, Hans Otto ; Lannig, Gisela. / Does the membrane pacemaker theory of metabolism explain the size dependence of metabolic rate in marine mussels?. In: Journal of Experimental Biology. 2017 ; Vol. 220, No. 8. pp. 1423-1434.

BibTeX

@article{8fe25ff0e58f46c9b0e6253a86c3e6f2,

title = "Does the membrane pacemaker theory of metabolism explain the size dependence of metabolic rate in marine mussels?",

abstract = "According to the membrane pacemaker theory of metabolism (MPT), allometric scaling of metabolic rate in animals is determined by the composition of cellular and mitochondrial membranes, which changes with body size in a predictable manner. MPT has been elaborated from interspecific comparisons in mammals. It projects that the degree of unsaturation of membrane phospholipids decreases in larger organisms, thereby lowering ion permeability of the membranes and making cellular, and thus whole-animal metabolism more efficient. Here, we tested the applicability of the MPT to a marine ectotherm, the mussel Mytilus edulis at the intraspecific level. We determined effects of body mass on wholeorganism, tissue and cellular oxygen consumption rates, on heart rate, metabolic enzyme activities and on the lipid composition of membranes. In line with allometric patterns, the organismal functions and processes such as heart rate, whole-animal respiration rate and phospholipid contents showed a mass-dependent decline. However, the allometry of tissue and cellular respiration and activity of metabolic enzymes was poor; fatty acid unsaturation of membrane phospholipids of gill tissue was independent of animal size. It is thus conceivable that most of the metabolic allometry observed at the organismal level is determined by systemic functions. These wholeorganism patterns may be supported by energy savings associated with growing cell size but not by structural changes in membranes. Overall, the set of processes contributing to metabolic allometry in ectotherms may differ from that operative in mammals and birds, with a reduced involvement of the mechanisms proposed by the MPT.",

keywords = "Allometric scaling, Cardiac magnetic resonance imaging, Cells, Enzyme activity, Fatty acids, Heart rate",

author = "Alexey Sukhotin and Natalia Fokina and Tatiana Ruokolainen and Christian Bock and P{\"o}rtner, {Hans Otto} and Gisela Lannig",

note = "Publisher Copyright: {\textcopyright} 2017. Published by The Company of Biologists Ltd.",

year = "2017",

month = apr,

day = "15",

doi = "10.1242/jeb.147108",

language = "English",

volume = "220",

pages = "1423--1434",

journal = "Journal of Experimental Biology",

issn = "0022-0949",

publisher = "Company of Biologists Ltd",

number = "8",