DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment : A 27-year follow-up. / O'Donnell, Kieran J.; Chen, Li; MacIsaac, Julia L.; McEwen, Lisa M.; Nguyen, Thao; Beckmann, Katherine; Zhu, Yuecai; Chen, Lawrence Ming; Brooks-Gunn, Jeanne; Goldman, David; Grigorenko, Elena L.; Leckman, James F.; Diorio, Josie; Karnani, Neerja; Olds, David L.; Holbrook, Joanna D.; Kobor, Michael S.; Meaney, Michael J.
In: Translational Psychiatry, Vol. 8, No. 1, 15, 10.01.2018.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment
T2 - A 27-year follow-up
AU - O'Donnell, Kieran J.
AU - Chen, Li
AU - MacIsaac, Julia L.
AU - McEwen, Lisa M.
AU - Nguyen, Thao
AU - Beckmann, Katherine
AU - Zhu, Yuecai
AU - Chen, Lawrence Ming
AU - Brooks-Gunn, Jeanne
AU - Goldman, David
AU - Grigorenko, Elena L.
AU - Leckman, James F.
AU - Diorio, Josie
AU - Karnani, Neerja
AU - Olds, David L.
AU - Holbrook, Joanna D.
AU - Kobor, Michael S.
AU - Meaney, Michael J.
PY - 2018/1/10
Y1 - 2018/1/10
N2 - This study reveals the influence of child maltreatment on DNA methylation across the genome and provides the first evidence that a psychosocial intervention program, the Nurse Family Partnership (NFP), which targets mothers at risk for abusive parenting, associates with variation in the DNA methylome in adult offspring. The 188 participants were born to women randomly assigned to control (n = 99) or nurse-visited intervention groups (n = 89) and provided blood samples and a diagnostic interview at age 27 years. Interindividual variation in the blood DNA methylome was described using principal components (PC) scores derived from principal component analysis and showed that the NFP program (PC10: p = 0.029) and a history of abuse/neglect (PC1: p = 0.029, PC2: p = 0.009) significantly associated with DNA methylome variation at 27 years of age independent of gender, ancestry, cellular heterogeneity, and a polygenic risk index for major psychiatric disorders. The magnitude of the association between child maltreatment and DNA methylation was reduced when accounting for lifestyle factors, including smoking. These findings reflect the sustained impact of both childhood adversity as well as intervention programs that target such adversity on the epigenome but highlight the need for prospective longitudinal studies of DNA methylome variation in the context of early intervention programs.
AB - This study reveals the influence of child maltreatment on DNA methylation across the genome and provides the first evidence that a psychosocial intervention program, the Nurse Family Partnership (NFP), which targets mothers at risk for abusive parenting, associates with variation in the DNA methylome in adult offspring. The 188 participants were born to women randomly assigned to control (n = 99) or nurse-visited intervention groups (n = 89) and provided blood samples and a diagnostic interview at age 27 years. Interindividual variation in the blood DNA methylome was described using principal components (PC) scores derived from principal component analysis and showed that the NFP program (PC10: p = 0.029) and a history of abuse/neglect (PC1: p = 0.029, PC2: p = 0.009) significantly associated with DNA methylome variation at 27 years of age independent of gender, ancestry, cellular heterogeneity, and a polygenic risk index for major psychiatric disorders. The magnitude of the association between child maltreatment and DNA methylation was reduced when accounting for lifestyle factors, including smoking. These findings reflect the sustained impact of both childhood adversity as well as intervention programs that target such adversity on the epigenome but highlight the need for prospective longitudinal studies of DNA methylome variation in the context of early intervention programs.
KW - Adolescent
KW - Adult
KW - Canada
KW - Child Abuse/prevention & control
KW - DNA Methylation
KW - Female
KW - Follow-Up Studies
KW - House Calls
KW - Humans
KW - Maternal-Child Nursing
KW - Mental Disorders/genetics
KW - Multifactorial Inheritance
KW - Nurse-Patient Relations
KW - Perinatal Care
KW - Pregnancy
KW - Prospective Studies
KW - Risk Factors
KW - Young Adult
KW - METHYLATION
KW - GLUCOCORTICOID-RECEPTOR
KW - ABUSE
KW - EPIGENETIC REGULATION
KW - HOME VISITATION
KW - GENE
KW - DEMETHYLATION
KW - GENOME-WIDE ANALYSIS
KW - PSYCHIATRIC-DISORDERS
KW - ASSOCIATION
UR - http://www.scopus.com/inward/record.url?scp=85040530218&partnerID=8YFLogxK
U2 - 10.1038/s41398-017-0063-9
DO - 10.1038/s41398-017-0063-9
M3 - Article
C2 - 29317599
AN - SCOPUS:85040530218
VL - 8
JO - Translational Psychiatry
JF - Translational Psychiatry
SN - 2158-3188
IS - 1
M1 - 15
ER -
ID: 36390275