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DNA methylation alterations in blood cells of toddlers with down syndrome. / Naumova, Oxana Yu; Lipschutz, Rebecca; Rychkov, Sergey Yu; Zhukova, Olga V.; Grigorenko, Elena L.

In: Genes, Vol. 12, No. 8, 1115, 23.07.2021.

Research output: Contribution to journal › Article › peer-review

Harvard

Naumova, OY, Lipschutz, R, Rychkov, SY, Zhukova, OV & Grigorenko, EL 2021, 'DNA methylation alterations in blood cells of toddlers with down syndrome', Genes, vol. 12, no. 8, 1115. https://doi.org/10.3390/genes12081115

APA

Naumova, O. Y., Lipschutz, R., Rychkov, S. Y., Zhukova, O. V., & Grigorenko, E. L. (2021). DNA methylation alterations in blood cells of toddlers with down syndrome. Genes, 12(8), [1115]. https://doi.org/10.3390/genes12081115

Vancouver

Naumova OY, Lipschutz R, Rychkov SY, Zhukova OV, Grigorenko EL. DNA methylation alterations in blood cells of toddlers with down syndrome. Genes. 2021 Jul 23;12(8). 1115. https://doi.org/10.3390/genes12081115

Author

Naumova, Oxana Yu ; Lipschutz, Rebecca ; Rychkov, Sergey Yu ; Zhukova, Olga V. ; Grigorenko, Elena L. / DNA methylation alterations in blood cells of toddlers with down syndrome. In: Genes. 2021 ; Vol. 12, No. 8.

BibTeX

@article{8201bb53fa1b49f1873f9c096b94397a,
title = "DNA methylation alterations in blood cells of toddlers with down syndrome",
abstract = "Recent research has provided evidence on genome-wide alterations in DNA methylation patterns due to trisomy 21, which have been detected in various tissues of individuals with Down syndrome (DS) across different developmental stages. Here, we report new data on the systematic genome-wide DNA methylation perturbations in blood cells of individuals with DS from a previously understudied age group-young children. We show that the study findings are highly consistent with those from the prior literature. In addition, utilizing relevant published data from two other developmental stages, neonatal and adult, we track a quasi-longitudinal trend in the DS-associated DNA methylation patterns as a systematic epigenomic destabilization with age.",
keywords = "DNA methylation, Down syndrome, Illumina 450k human methylation array, Infants and toddlers, Trisomy 21, Illumina 450K Human Methylation Array, ABNORMALITIES, trisomy 21, infants and toddlers, TRISOMY-21, CHILDREN, IMMUNE-SYSTEM, GENOME-WIDE IMPACT, DYSREGULATION, ONTOLOGY, TOOL",
author = "Naumova, {Oxana Yu} and Rebecca Lipschutz and Rychkov, {Sergey Yu} and Zhukova, {Olga V.} and Grigorenko, {Elena L.}",
note = "Naumova, O.Y.; Lipschutz, R.; Rychkov, S.Y.; Zhukova, O.V.; Grigorenko, E.L. DNA Methylation Alterations in Blood Cells of Toddlers with Down Syndrome. Genes 2021, 12, 1115. https://doi.org/10.3390/genes12081115",
year = "2021",
month = jul,
day = "23",
doi = "10.3390/genes12081115",
language = "English",
volume = "12",
journal = "Genes",
issn = "2073-4425",
publisher = "MDPI AG",
number = "8",

}

RIS

TY - JOUR

T1 - DNA methylation alterations in blood cells of toddlers with down syndrome

AU - Naumova, Oxana Yu

AU - Lipschutz, Rebecca

AU - Rychkov, Sergey Yu

AU - Zhukova, Olga V.

AU - Grigorenko, Elena L.

N1 - Naumova, O.Y.; Lipschutz, R.; Rychkov, S.Y.; Zhukova, O.V.; Grigorenko, E.L. DNA Methylation Alterations in Blood Cells of Toddlers with Down Syndrome. Genes 2021, 12, 1115. https://doi.org/10.3390/genes12081115

PY - 2021/7/23

Y1 - 2021/7/23

N2 - Recent research has provided evidence on genome-wide alterations in DNA methylation patterns due to trisomy 21, which have been detected in various tissues of individuals with Down syndrome (DS) across different developmental stages. Here, we report new data on the systematic genome-wide DNA methylation perturbations in blood cells of individuals with DS from a previously understudied age group-young children. We show that the study findings are highly consistent with those from the prior literature. In addition, utilizing relevant published data from two other developmental stages, neonatal and adult, we track a quasi-longitudinal trend in the DS-associated DNA methylation patterns as a systematic epigenomic destabilization with age.

AB - Recent research has provided evidence on genome-wide alterations in DNA methylation patterns due to trisomy 21, which have been detected in various tissues of individuals with Down syndrome (DS) across different developmental stages. Here, we report new data on the systematic genome-wide DNA methylation perturbations in blood cells of individuals with DS from a previously understudied age group-young children. We show that the study findings are highly consistent with those from the prior literature. In addition, utilizing relevant published data from two other developmental stages, neonatal and adult, we track a quasi-longitudinal trend in the DS-associated DNA methylation patterns as a systematic epigenomic destabilization with age.

KW - DNA methylation

KW - Down syndrome

KW - Illumina 450k human methylation array

KW - Infants and toddlers

KW - Trisomy 21

KW - Illumina 450K Human Methylation Array

KW - ABNORMALITIES

KW - trisomy 21

KW - infants and toddlers

KW - TRISOMY-21

KW - CHILDREN

KW - IMMUNE-SYSTEM

KW - GENOME-WIDE IMPACT

KW - DYSREGULATION

KW - ONTOLOGY

KW - TOOL

UR - http://www.scopus.com/inward/record.url?scp=85111425942&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/14a1c697-65d4-329d-a13a-753ef550262b/

U2 - 10.3390/genes12081115

DO - 10.3390/genes12081115

M3 - Article

C2 - 34440289

AN - SCOPUS:85111425942

VL - 12

JO - Genes

JF - Genes

SN - 2073-4425

IS - 8

M1 - 1115

ER -

ID: 86655940