DISTURBANCES IN DIFFERENTIATION AND POLARIZATION OF PERIPHERAL BLOOD T-HELPER CELLS IN PATIENTS WITH MULTIPLE SCLEROSIS Background

Multiple sclerosis (MS) is an autoimmune disease targeting the central nervous system with neurodegeneration and neuroinflammation. The underlying mechanisms of MS are not fully understood yet, but CD3+CD4+ T cells (Th) are thought to be of importance in disease pathogenesis.