Research output: Contribution to journal › Article › peer-review
Distribution of structural polymorphisms of angiotensin converting enzyme and serotonin receptor (5-HT2A) genes among long-living individuals from Northwestern Russia. / Smirnova, T.Y.; Spivak, D.L.; Yakupova, G.S.; Zakharchuk, A.G.; Spivak, I.M.
In: Advances in Gerontology (Uspekhi Gerontologii), Vol. 2, No. 3, 2012, p. 247-252.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Distribution of structural polymorphisms of angiotensin converting enzyme and serotonin receptor (5-HT2A) genes among long-living individuals from Northwestern Russia
AU - Smirnova, T.Y.
AU - Spivak, D.L.
AU - Yakupova, G.S.
AU - Zakharchuk, A.G.
AU - Spivak, I.M.
PY - 2012
Y1 - 2012
N2 - The I/D polymorphism of the angiotensin converting enzyme (ACE) gene and C102T polymorphism of the serotonin receptor gene (5-HT2A) were studied in a group of long-living individuals from northwestern Russia. No significant differences in allele frequencies of these genes were detected between long-living individuals and young people. At the same time, strongly pronounced differences in the 5-HT2A gene A1 and A2 alleles in populations of the northwestern region of the Russian Federation and the United States (0.397 (A1) and 0.603 (A2), and 0.615 (A1) and 0.385 (A2), respectively) were detected. These significant population differences deserve serious attention and a detailed analysis of polymorphism in other serotonin system genes in different populations of Russian Federation. © Pleiades Publishing, Ltd., 2012.
AB - The I/D polymorphism of the angiotensin converting enzyme (ACE) gene and C102T polymorphism of the serotonin receptor gene (5-HT2A) were studied in a group of long-living individuals from northwestern Russia. No significant differences in allele frequencies of these genes were detected between long-living individuals and young people. At the same time, strongly pronounced differences in the 5-HT2A gene A1 and A2 alleles in populations of the northwestern region of the Russian Federation and the United States (0.397 (A1) and 0.603 (A2), and 0.615 (A1) and 0.385 (A2), respectively) were detected. These significant population differences deserve serious attention and a detailed analysis of polymorphism in other serotonin system genes in different populations of Russian Federation. © Pleiades Publishing, Ltd., 2012.
U2 - 10.1134/S2079057012030149
DO - 10.1134/S2079057012030149
M3 - Article
VL - 2
SP - 247
EP - 252
JO - Advances in Gerontology
JF - Advances in Gerontology
SN - 2079-0570
IS - 3
ER -
ID: 5548910