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Discovery of Strecker-type alpha-aminonitriles as a new class of human carbonic anhydrase inhibitors using differential scanning fluorimetry. / Krasavin, Mikhail; Stavniichuk, Roman; Zozulya, Sergey; Borysko, Petro; Vullo, Daniela; Supuran, Claudiu T.

In: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 31, No. 6, 2016, p. 1707-1711.

Research output: Contribution to journal › Article › peer-review

Harvard

Krasavin, M, Stavniichuk, R, Zozulya, S, Borysko, P, Vullo, D & Supuran, CT 2016, 'Discovery of Strecker-type alpha-aminonitriles as a new class of human carbonic anhydrase inhibitors using differential scanning fluorimetry', Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 31, no. 6, pp. 1707-1711. https://doi.org/10.3109/14756366.2016.1156676, https://doi.org/10.3109/14756366.2016.1156676

APA

Krasavin, M., Stavniichuk, R., Zozulya, S., Borysko, P., Vullo, D., & Supuran, C. T. (2016). Discovery of Strecker-type alpha-aminonitriles as a new class of human carbonic anhydrase inhibitors using differential scanning fluorimetry. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(6), 1707-1711. https://doi.org/10.3109/14756366.2016.1156676, https://doi.org/10.3109/14756366.2016.1156676

Vancouver

Krasavin M, Stavniichuk R, Zozulya S, Borysko P, Vullo D, Supuran CT. Discovery of Strecker-type alpha-aminonitriles as a new class of human carbonic anhydrase inhibitors using differential scanning fluorimetry. Journal of Enzyme Inhibition and Medicinal Chemistry. 2016;31(6):1707-1711. https://doi.org/10.3109/14756366.2016.1156676, https://doi.org/10.3109/14756366.2016.1156676

Author

Krasavin, Mikhail ; Stavniichuk, Roman ; Zozulya, Sergey ; Borysko, Petro ; Vullo, Daniela ; Supuran, Claudiu T. / Discovery of Strecker-type alpha-aminonitriles as a new class of human carbonic anhydrase inhibitors using differential scanning fluorimetry. In: Journal of Enzyme Inhibition and Medicinal Chemistry. 2016 ; Vol. 31, No. 6. pp. 1707-1711.

BibTeX

@article{f9a490da29ac4e868bb40eded05da025,
title = "Discovery of Strecker-type alpha-aminonitriles as a new class of human carbonic anhydrase inhibitors using differential scanning fluorimetry",
abstract = "A new type of carbonic anhydrase inhibitors was identified via differential scanning fluorimetry (DSF) screening. The compounds displayed interesting inhibition profile against human carbonic anhydrase isoforms I, II, IX and XII with an obvious selectivity displayed by one compound toward carbonic anhydrase (CA) IX, an established anti-cancer target. A hypothetical mechanism of inhibitory action by the Strecker-type alpha-aminonitriles has been proposed.",
keywords = "Carbonic anhydrases, cyanide donors, differential scanning fluorimetry, isoform selectivity, protein affinity, suicide inhibitors, thermal shift assay, IX, STABILITY, AFFINITY, DESIGN, SITE",
author = "Mikhail Krasavin and Roman Stavniichuk and Sergey Zozulya and Petro Borysko and Daniela Vullo and Supuran, {Claudiu T.}",
year = "2016",
doi = "10.3109/14756366.2016.1156676",
language = "Английский",
volume = "31",
pages = "1707--1711",
journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",
issn = "1475-6366",
publisher = "Taylor & Francis",
number = "6",

}

RIS

TY - JOUR

T1 - Discovery of Strecker-type alpha-aminonitriles as a new class of human carbonic anhydrase inhibitors using differential scanning fluorimetry

AU - Krasavin, Mikhail

AU - Stavniichuk, Roman

AU - Zozulya, Sergey

AU - Borysko, Petro

AU - Vullo, Daniela

AU - Supuran, Claudiu T.

PY - 2016

Y1 - 2016

N2 - A new type of carbonic anhydrase inhibitors was identified via differential scanning fluorimetry (DSF) screening. The compounds displayed interesting inhibition profile against human carbonic anhydrase isoforms I, II, IX and XII with an obvious selectivity displayed by one compound toward carbonic anhydrase (CA) IX, an established anti-cancer target. A hypothetical mechanism of inhibitory action by the Strecker-type alpha-aminonitriles has been proposed.

AB - A new type of carbonic anhydrase inhibitors was identified via differential scanning fluorimetry (DSF) screening. The compounds displayed interesting inhibition profile against human carbonic anhydrase isoforms I, II, IX and XII with an obvious selectivity displayed by one compound toward carbonic anhydrase (CA) IX, an established anti-cancer target. A hypothetical mechanism of inhibitory action by the Strecker-type alpha-aminonitriles has been proposed.

KW - Carbonic anhydrases

KW - cyanide donors

KW - differential scanning fluorimetry

KW - isoform selectivity

KW - protein affinity

KW - suicide inhibitors

KW - thermal shift assay

KW - IX

KW - STABILITY

KW - AFFINITY

KW - DESIGN

KW - SITE

U2 - 10.3109/14756366.2016.1156676

DO - 10.3109/14756366.2016.1156676

M3 - статья

VL - 31

SP - 1707

EP - 1711

JO - Journal of Enzyme Inhibition and Medicinal Chemistry

JF - Journal of Enzyme Inhibition and Medicinal Chemistry

SN - 1475-6366

IS - 6

ER -

ID: 9433063