Diethanolammonium protic ionic liquids - promising buffers for the synthesis of 68Ga- labelled radiopharmaceuticals

Diethanolammonium protic ionic liquids - promising buffers for the synthesis of ⁶⁸Ga- labelled radiopharmaceuticals

Research output: Contribution to journal › Article › peer-review

DOI

https://doi.org/10.1016/j.molliq.2021.117029
Final published version

Yulia A. Kondratenko
Dmitrii O. Antuganov
Andrey A. Zolotarev
Michail A. Nadporojskii
Valery L. Ugolkov
Tatyana A. Kochina

Fifteen new protic ionic liquids based on diethanolammonium (DEA) salts of carboxylic acids have been synthesized and identified using a complex of physicochemical methods (NMR, FT-IR spectroscopy, elemental, thermal analysis). The crystal structure of diethanolammonium salts of benzoic and 1-hydroxy-2-naphthoic acids was determined for the first time by XRD. A comparative analysis of the conformations of DEA cations was carried out. The effectiveness of synthesized DEA ionic liquids as buffer agents was demonstrated on ⁶⁸Ga-radiolabeling reactions with different chelators and clinically approved peptides.

Original language	English
Article number	117029
Number of pages	10
Journal	Journal of Molecular Liquids
Volume	345
DOIs	https://doi.org/10.1016/j.molliq.2021.117029
State	Published - 1 Jan 2022

Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Materials Chemistry
Atomic and Molecular Physics, and Optics
Spectroscopy
Physical and Theoretical Chemistry

Research areas

Buffer activity, Cation conformation, Diethanolamine, PET, Protic ionic liquids, Radiolabeling, Room-temperature ionic liquids, ACID, CO2, ENZYME, MEDIA, TRIETHANOLAMMONIUM SALTS, GOODS BUFFERS

ID: 88857907