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Diaminocarbene Complexes of Palladium(II) Containing 2-Aminooxazole and 2-Aminothiazole Heterocyclic Ligands as Potential Antitumor Agents. / Boyarskii, V. P.; Mikherdov, A. S.; Baikov, S. V.; Savko, P. Yu; Suezov, R. V.; Trifonov, R. E.

In: Pharmaceutical Chemistry Journal, Vol. 55, No. 2, 01.05.2021, p. 130-132.

Research output: Contribution to journal › Article › peer-review

Harvard

Boyarskii, VP, Mikherdov, AS, Baikov, SV, Savko, PY, Suezov, RV & Trifonov, RE 2021, 'Diaminocarbene Complexes of Palladium(II) Containing 2-Aminooxazole and 2-Aminothiazole Heterocyclic Ligands as Potential Antitumor Agents', Pharmaceutical Chemistry Journal, vol. 55, no. 2, pp. 130-132. https://doi.org/10.1007/s11094-021-02393-1

APA

Boyarskii, V. P., Mikherdov, A. S., Baikov, S. V., Savko, P. Y., Suezov, R. V., & Trifonov, R. E. (2021). Diaminocarbene Complexes of Palladium(II) Containing 2-Aminooxazole and 2-Aminothiazole Heterocyclic Ligands as Potential Antitumor Agents. Pharmaceutical Chemistry Journal, 55(2), 130-132. https://doi.org/10.1007/s11094-021-02393-1

Vancouver

Boyarskii VP, Mikherdov AS, Baikov SV, Savko PY, Suezov RV, Trifonov RE. Diaminocarbene Complexes of Palladium(II) Containing 2-Aminooxazole and 2-Aminothiazole Heterocyclic Ligands as Potential Antitumor Agents. Pharmaceutical Chemistry Journal. 2021 May 1;55(2):130-132. https://doi.org/10.1007/s11094-021-02393-1

Author

Boyarskii, V. P. ; Mikherdov, A. S. ; Baikov, S. V. ; Savko, P. Yu ; Suezov, R. V. ; Trifonov, R. E. / Diaminocarbene Complexes of Palladium(II) Containing 2-Aminooxazole and 2-Aminothiazole Heterocyclic Ligands as Potential Antitumor Agents. In: Pharmaceutical Chemistry Journal. 2021 ; Vol. 55, No. 2. pp. 130-132.

BibTeX

@article{fd8b737c57374e48ae0c5b4982ead038,
title = "Diaminocarbene Complexes of Palladium(II) Containing 2-Aminooxazole and 2-Aminothiazole Heterocyclic Ligands as Potential Antitumor Agents",
abstract = "A new diaminocarbene cis-palladium(II) complex containing a 2-aminobenzoxazole ligand was synthesized by reacting cis-[PdCl2(CNCy)2] and 2-aminobenzoxazole. The structure and composition of the obtained complex were proven by NMR spectroscopy and high-resolution mass spectrometry. The cytotoxicities of the obtained complex and structurally similar palladium(II) complexes containing a 2-aminothiazole ligand were tested against human cancer cells of various histogenesis (MCF-7, HL60, HeLa, DLD1, A431). The activities of several complexes against cancer cells were higher than those of the reference drug cisplatin and the free ligands, i.e., 2-aminooxazole and substituted 2-aminothiazoles.",
keywords = "2-aminooxazole, 2-aminothiazole, cytotoxicity, diaminocarbene complexes, heterocyclic ligands",
author = "Boyarskii, {V. P.} and Mikherdov, {A. S.} and Baikov, {S. V.} and Savko, {P. Yu} and Suezov, {R. V.} and Trifonov, {R. E.}",
note = "Publisher Copyright: {\textcopyright} 2021, Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2021",
month = may,
day = "1",
doi = "10.1007/s11094-021-02393-1",
language = "English",
volume = "55",
pages = "130--132",
journal = "Pharmaceutical Chemistry Journal",
issn = "0091-150X",
publisher = "Springer Nature",
number = "2",

}

RIS

TY - JOUR

T1 - Diaminocarbene Complexes of Palladium(II) Containing 2-Aminooxazole and 2-Aminothiazole Heterocyclic Ligands as Potential Antitumor Agents

AU - Boyarskii, V. P.

AU - Mikherdov, A. S.

AU - Baikov, S. V.

AU - Savko, P. Yu

AU - Suezov, R. V.

AU - Trifonov, R. E.

N1 - Publisher Copyright: © 2021, Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2021/5/1

Y1 - 2021/5/1

N2 - A new diaminocarbene cis-palladium(II) complex containing a 2-aminobenzoxazole ligand was synthesized by reacting cis-[PdCl2(CNCy)2] and 2-aminobenzoxazole. The structure and composition of the obtained complex were proven by NMR spectroscopy and high-resolution mass spectrometry. The cytotoxicities of the obtained complex and structurally similar palladium(II) complexes containing a 2-aminothiazole ligand were tested against human cancer cells of various histogenesis (MCF-7, HL60, HeLa, DLD1, A431). The activities of several complexes against cancer cells were higher than those of the reference drug cisplatin and the free ligands, i.e., 2-aminooxazole and substituted 2-aminothiazoles.

AB - A new diaminocarbene cis-palladium(II) complex containing a 2-aminobenzoxazole ligand was synthesized by reacting cis-[PdCl2(CNCy)2] and 2-aminobenzoxazole. The structure and composition of the obtained complex were proven by NMR spectroscopy and high-resolution mass spectrometry. The cytotoxicities of the obtained complex and structurally similar palladium(II) complexes containing a 2-aminothiazole ligand were tested against human cancer cells of various histogenesis (MCF-7, HL60, HeLa, DLD1, A431). The activities of several complexes against cancer cells were higher than those of the reference drug cisplatin and the free ligands, i.e., 2-aminooxazole and substituted 2-aminothiazoles.

KW - 2-aminooxazole

KW - 2-aminothiazole

KW - cytotoxicity

KW - diaminocarbene complexes

KW - heterocyclic ligands

UR - http://www.scopus.com/inward/record.url?scp=85105386248&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/6fe69eca-6db9-36ac-b5f5-8438918ec7c3/

U2 - 10.1007/s11094-021-02393-1

DO - 10.1007/s11094-021-02393-1

M3 - Article

AN - SCOPUS:85105386248

VL - 55

SP - 130

EP - 132

JO - Pharmaceutical Chemistry Journal

JF - Pharmaceutical Chemistry Journal

SN - 0091-150X

IS - 2

ER -

ID: 87469275