Standard

Diagnosis of cutaneous graft-versus-host disease : Pathomorphological aspects. / Krivolapova, A. Yu; Belousova, I. E.; Smirnova, I. O.; Lisukova, E. V.; Baikov, V. V.

In: Arkhiv Patologii, Vol. 76, No. 4, 01.01.2014, p. 24-28.

Research output: Contribution to journal › Article › peer-review

Harvard

Krivolapova, AY, Belousova, IE, Smirnova, IO, Lisukova, EV & Baikov, VV 2014, 'Diagnosis of cutaneous graft-versus-host disease: Pathomorphological aspects', Arkhiv Patologii, vol. 76, no. 4, pp. 24-28.

APA

Krivolapova, A. Y., Belousova, I. E., Smirnova, I. O., Lisukova, E. V., & Baikov, V. V. (2014). Diagnosis of cutaneous graft-versus-host disease: Pathomorphological aspects. Arkhiv Patologii, 76(4), 24-28.

Vancouver

Krivolapova AY, Belousova IE, Smirnova IO, Lisukova EV, Baikov VV. Diagnosis of cutaneous graft-versus-host disease: Pathomorphological aspects. Arkhiv Patologii. 2014 Jan 1;76(4):24-28.

Author

Krivolapova, A. Yu ; Belousova, I. E. ; Smirnova, I. O. ; Lisukova, E. V. ; Baikov, V. V. / Diagnosis of cutaneous graft-versus-host disease : Pathomorphological aspects. In: Arkhiv Patologii. 2014 ; Vol. 76, No. 4. pp. 24-28.

BibTeX

@article{45f01387189e4bb78277832afa0c32b1,
title = "Diagnosis of cutaneous graft-versus-host disease: Pathomorphological aspects",
abstract = "Objective. To study the differential diagnostic value of histological and immunohistochemical signs in skin biopsy specimens in graft-versus-host disease (GVHD). Material and methods. Hematoxylin- and eosin-stained skin biopsy specimens from 50 patients with GVHD and 10 patients with toxicoderma were examined; immunohistochemical reactions using antibodies against CD3, CD20, CD4, CD8, FOXP3, CD56, CDIa, and CD68 were performed. The significance of differences between the groups was estimated using the X2 and Mann-Whitney tests. Results. In GVHD, there was a significantly high count of necrotic epidermocytes with satellite cells in the epidermis, more commonly apoptosis of epitheliocytes in the skin appendages and vacuolar dystrophy of epidermocytes. On the contrary, the count of eosinophilic granulocytes, CD1a+ CD3+, FOXP3+, and CD8+ cells and the proportion of FOXP3+ cells proved to be significantly higher in the toxicoderma group. Conclusion. The results of the investigation were used to form groups of signs that were important in the differential diagnosis of cutaneous GVHD and toxic and allergic reactions.",
keywords = "Graft-versus-host disease, Immunohistochemistry, Skin",
author = "Krivolapova, {A. Yu} and Belousova, {I. E.} and Smirnova, {I. O.} and Lisukova, {E. V.} and Baikov, {V. V.}",
year = "2014",
month = jan,
day = "1",
language = "русский",
volume = "76",
pages = "24--28",
journal = "АРХИВ ПАТОЛОГИИ",
issn = "0004-1955",
publisher = "Медиа Сфера",
number = "4",

}

RIS

TY - JOUR

T1 - Diagnosis of cutaneous graft-versus-host disease

T2 - Pathomorphological aspects

AU - Krivolapova, A. Yu

AU - Belousova, I. E.

AU - Smirnova, I. O.

AU - Lisukova, E. V.

AU - Baikov, V. V.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Objective. To study the differential diagnostic value of histological and immunohistochemical signs in skin biopsy specimens in graft-versus-host disease (GVHD). Material and methods. Hematoxylin- and eosin-stained skin biopsy specimens from 50 patients with GVHD and 10 patients with toxicoderma were examined; immunohistochemical reactions using antibodies against CD3, CD20, CD4, CD8, FOXP3, CD56, CDIa, and CD68 were performed. The significance of differences between the groups was estimated using the X2 and Mann-Whitney tests. Results. In GVHD, there was a significantly high count of necrotic epidermocytes with satellite cells in the epidermis, more commonly apoptosis of epitheliocytes in the skin appendages and vacuolar dystrophy of epidermocytes. On the contrary, the count of eosinophilic granulocytes, CD1a+ CD3+, FOXP3+, and CD8+ cells and the proportion of FOXP3+ cells proved to be significantly higher in the toxicoderma group. Conclusion. The results of the investigation were used to form groups of signs that were important in the differential diagnosis of cutaneous GVHD and toxic and allergic reactions.

AB - Objective. To study the differential diagnostic value of histological and immunohistochemical signs in skin biopsy specimens in graft-versus-host disease (GVHD). Material and methods. Hematoxylin- and eosin-stained skin biopsy specimens from 50 patients with GVHD and 10 patients with toxicoderma were examined; immunohistochemical reactions using antibodies against CD3, CD20, CD4, CD8, FOXP3, CD56, CDIa, and CD68 were performed. The significance of differences between the groups was estimated using the X2 and Mann-Whitney tests. Results. In GVHD, there was a significantly high count of necrotic epidermocytes with satellite cells in the epidermis, more commonly apoptosis of epitheliocytes in the skin appendages and vacuolar dystrophy of epidermocytes. On the contrary, the count of eosinophilic granulocytes, CD1a+ CD3+, FOXP3+, and CD8+ cells and the proportion of FOXP3+ cells proved to be significantly higher in the toxicoderma group. Conclusion. The results of the investigation were used to form groups of signs that were important in the differential diagnosis of cutaneous GVHD and toxic and allergic reactions.

KW - Graft-versus-host disease

KW - Immunohistochemistry

KW - Skin

UR - http://www.scopus.com/inward/record.url?scp=84923300056&partnerID=8YFLogxK

M3 - статья

C2 - 25306621

AN - SCOPUS:84923300056

VL - 76

SP - 24

EP - 28

JO - АРХИВ ПАТОЛОГИИ

JF - АРХИВ ПАТОЛОГИИ

SN - 0004-1955

IS - 4

ER -

ID: 49817470