We study the topological entropy for dynamical systems with discrete or continuous multiple time. Due to the generalization of a well-known one time-dimensional result we show that the definition of topological entropy, using the approach for subshifts, leads to the zero entropy for many systems different from subshift. We define a new type of relative topological entropy to avoid this phenomenon. The generalization of Bowen’s power rule allows us to define topological and relative topological entropies for systems with continuous multiple time. As an application, we find a relation between the relative topological entropy and controllability of linear systems with continuous multiple time.