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Developing zebrafish models of Notch-related CNS pathologies. / Ерофеева, Наталья Олеговна; Галстян, Давид Самвелович; Yang, Longen; Strekalova, Tatiana; Lim, Lee Wei; de Abreu, Murilo S; Голушко, Никита Игоревич; Stewart, Adam Michael; Калуев, Алан Валерьевич.

In: Neuroscience and Biobehavioral Reviews, Vol. 170, 106059, 03.2025.

Research output: Contribution to journal › Article › peer-review

Harvard

Ерофеева, НО, Галстян, ДС, Yang, L, Strekalova, T, Lim, LW, de Abreu, MS, Голушко, НИ, Stewart, AM & Калуев, АВ 2025, 'Developing zebrafish models of Notch-related CNS pathologies', Neuroscience and Biobehavioral Reviews, vol. 170, 106059. https://doi.org/10.1016/j.neubiorev.2025.106059

APA

Ерофеева, Н. О., Галстян, Д. С., Yang, L., Strekalova, T., Lim, L. W., de Abreu, M. S., Голушко, Н. И., Stewart, A. M., & Калуев, А. В. (2025). Developing zebrafish models of Notch-related CNS pathologies. Neuroscience and Biobehavioral Reviews, 170, [106059]. https://doi.org/10.1016/j.neubiorev.2025.106059

Vancouver

Ерофеева НО, Галстян ДС, Yang L, Strekalova T, Lim LW, de Abreu MS et al. Developing zebrafish models of Notch-related CNS pathologies. Neuroscience and Biobehavioral Reviews. 2025 Mar;170. 106059. https://doi.org/10.1016/j.neubiorev.2025.106059

Author

Ерофеева, Наталья Олеговна ; Галстян, Давид Самвелович ; Yang, Longen ; Strekalova, Tatiana ; Lim, Lee Wei ; de Abreu, Murilo S ; Голушко, Никита Игоревич ; Stewart, Adam Michael ; Калуев, Алан Валерьевич. / Developing zebrafish models of Notch-related CNS pathologies. In: Neuroscience and Biobehavioral Reviews. 2025 ; Vol. 170.

BibTeX

@article{3eeacf33c477440eb1c1a84fe9d7fc7b,
title = "Developing zebrafish models of Notch-related CNS pathologies",
abstract = "Notch signaling is an evolutionarily conserved cellular pathway that regulates various stem cell functions, including fate determination, differentiation, proliferation, and apoptosis. This crucial signaling mechanism also plays an important role in the brain, regulating neurogenesis, cell differentiation, and homeostasis, whereas disrupted Notch signaling is linked to various neurodegenerative diseases and brain cancers. Here, we review the central nervous system (CNS) pathologies associated with aberrant Notch signaling, and summarize the available experimental (animal) models used to study these pathologies, with a special focus on zebrafish (Danio rerio). As genetic, pharmacological, and behavioral models in zebrafish have significantly advanced our understanding of Notch-related CNS disorders, future research is expected to further link Notch signaling to brain disorders and, eventually, lead to their more specific and targeted therapeuties.",
keywords = "Animal model, Neurodegeneration, Notch signaling pathway, Zebrafish",
author = "Ерофеева, {Наталья Олеговна} and Галстян, {Давид Самвелович} and Longen Yang and Tatiana Strekalova and Lim, {Lee Wei} and {de Abreu}, {Murilo S} and Голушко, {Никита Игоревич} and Stewart, {Adam Michael} and Калуев, {Алан Валерьевич}",
year = "2025",
month = mar,
doi = "10.1016/j.neubiorev.2025.106059",
language = "English",
volume = "170",
journal = "Neuroscience and Biobehavioral Reviews",
issn = "0149-7634",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Developing zebrafish models of Notch-related CNS pathologies

AU - Ерофеева, Наталья Олеговна

AU - Галстян, Давид Самвелович

AU - Yang, Longen

AU - Strekalova, Tatiana

AU - Lim, Lee Wei

AU - de Abreu, Murilo S

AU - Голушко, Никита Игоревич

AU - Stewart, Adam Michael

AU - Калуев, Алан Валерьевич

PY - 2025/3

Y1 - 2025/3

N2 - Notch signaling is an evolutionarily conserved cellular pathway that regulates various stem cell functions, including fate determination, differentiation, proliferation, and apoptosis. This crucial signaling mechanism also plays an important role in the brain, regulating neurogenesis, cell differentiation, and homeostasis, whereas disrupted Notch signaling is linked to various neurodegenerative diseases and brain cancers. Here, we review the central nervous system (CNS) pathologies associated with aberrant Notch signaling, and summarize the available experimental (animal) models used to study these pathologies, with a special focus on zebrafish (Danio rerio). As genetic, pharmacological, and behavioral models in zebrafish have significantly advanced our understanding of Notch-related CNS disorders, future research is expected to further link Notch signaling to brain disorders and, eventually, lead to their more specific and targeted therapeuties.

AB - Notch signaling is an evolutionarily conserved cellular pathway that regulates various stem cell functions, including fate determination, differentiation, proliferation, and apoptosis. This crucial signaling mechanism also plays an important role in the brain, regulating neurogenesis, cell differentiation, and homeostasis, whereas disrupted Notch signaling is linked to various neurodegenerative diseases and brain cancers. Here, we review the central nervous system (CNS) pathologies associated with aberrant Notch signaling, and summarize the available experimental (animal) models used to study these pathologies, with a special focus on zebrafish (Danio rerio). As genetic, pharmacological, and behavioral models in zebrafish have significantly advanced our understanding of Notch-related CNS disorders, future research is expected to further link Notch signaling to brain disorders and, eventually, lead to their more specific and targeted therapeuties.

KW - Animal model

KW - Neurodegeneration

KW - Notch signaling pathway

KW - Zebrafish

UR - https://www.sciencedirect.com/science/article/abs/pii/S0149763425000594?via%3Dihub

UR - https://www.mendeley.com/catalogue/c77022ce-ba20-3a9b-8ef5-efebc4c6f3cf/

U2 - 10.1016/j.neubiorev.2025.106059

DO - 10.1016/j.neubiorev.2025.106059

M3 - Article

VL - 170

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

SN - 0149-7634

M1 - 106059

ER -

ID: 135555926