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Developing zebrafish models for the study of Wnt-related central nervous system pathologies. / Ерофеева, Наталья Олеговна; de Abreu, Murilo S; Jiahao Cui; Lim, Lee Wei; Yang, LongEn; Калуев, Алан Валерьевич.

In: Neuroscience, Vol. 579, 23.07.2025, p. 239-249.

Research output: Contribution to journal › Article › peer-review

Harvard

Ерофеева, НО, de Abreu, MS, Jiahao Cui, Lim, LW, Yang, L & Калуев, АВ 2025, 'Developing zebrafish models for the study of Wnt-related central nervous system pathologies', Neuroscience, vol. 579, pp. 239-249. https://doi.org/10.1016/j.neuroscience.2025.06.003

APA

Ерофеева, Н. О., de Abreu, M. S., Jiahao Cui, Lim, L. W., Yang, L., & Калуев, А. В. (2025). Developing zebrafish models for the study of Wnt-related central nervous system pathologies. Neuroscience, 579, 239-249. https://doi.org/10.1016/j.neuroscience.2025.06.003

Vancouver

Ерофеева НО, de Abreu MS, Jiahao Cui, Lim LW, Yang L, Калуев АВ. Developing zebrafish models for the study of Wnt-related central nervous system pathologies. Neuroscience. 2025 Jul 23;579:239-249. https://doi.org/10.1016/j.neuroscience.2025.06.003

Author

Ерофеева, Наталья Олеговна ; de Abreu, Murilo S ; Jiahao Cui ; Lim, Lee Wei ; Yang, LongEn ; Калуев, Алан Валерьевич. / Developing zebrafish models for the study of Wnt-related central nervous system pathologies. In: Neuroscience. 2025 ; Vol. 579. pp. 239-249.

BibTeX

@article{05a694cebaac45ff9e259eec3db8262d,
title = "Developing zebrafish models for the study of Wnt-related central nervous system pathologies",
abstract = "The wingless-related integration site (Wnt) signaling pathway plays a crucial role in the development and pathology of the central nervous system (CNS), modulating neurogenesis, synaptic plasticity, and cell fate determination. Dysregulation of this pathway is strongly implicated in the pathogenesis of several CNS disorders. Recognizing the growing importance of Wnt signaling in the brain, here we provide novel insights into experimental animal models studying this mechanism, with a particular emphasis on zebrafish (Danio rerio), including CNS development, and high-throughput drug screening of compounds that modulate Wnt signaling. Despite certain limitations, zebrafish provide a promising and powerful model system to increase our understanding of the role of Wnt signaling in CNS function, and to foster the development of novel therapies for brain disorders associated with this signaling pathway.",
keywords = "Animal model, Neurodegeneration, Wnt-signaling pathway, Zebrafish",
author = "Ерофеева, {Наталья Олеговна} and {de Abreu}, {Murilo S} and {Jiahao Cui} and Lim, {Lee Wei} and LongEn Yang and Калуев, {Алан Валерьевич}",
year = "2025",
month = jul,
day = "23",
doi = "10.1016/j.neuroscience.2025.06.003",
language = "English",
volume = "579",
pages = "239--249",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Developing zebrafish models for the study of Wnt-related central nervous system pathologies

AU - Ерофеева, Наталья Олеговна

AU - de Abreu, Murilo S

AU - Jiahao Cui,

AU - Lim, Lee Wei

AU - Yang, LongEn

AU - Калуев, Алан Валерьевич

PY - 2025/7/23

Y1 - 2025/7/23

N2 - The wingless-related integration site (Wnt) signaling pathway plays a crucial role in the development and pathology of the central nervous system (CNS), modulating neurogenesis, synaptic plasticity, and cell fate determination. Dysregulation of this pathway is strongly implicated in the pathogenesis of several CNS disorders. Recognizing the growing importance of Wnt signaling in the brain, here we provide novel insights into experimental animal models studying this mechanism, with a particular emphasis on zebrafish (Danio rerio), including CNS development, and high-throughput drug screening of compounds that modulate Wnt signaling. Despite certain limitations, zebrafish provide a promising and powerful model system to increase our understanding of the role of Wnt signaling in CNS function, and to foster the development of novel therapies for brain disorders associated with this signaling pathway.

AB - The wingless-related integration site (Wnt) signaling pathway plays a crucial role in the development and pathology of the central nervous system (CNS), modulating neurogenesis, synaptic plasticity, and cell fate determination. Dysregulation of this pathway is strongly implicated in the pathogenesis of several CNS disorders. Recognizing the growing importance of Wnt signaling in the brain, here we provide novel insights into experimental animal models studying this mechanism, with a particular emphasis on zebrafish (Danio rerio), including CNS development, and high-throughput drug screening of compounds that modulate Wnt signaling. Despite certain limitations, zebrafish provide a promising and powerful model system to increase our understanding of the role of Wnt signaling in CNS function, and to foster the development of novel therapies for brain disorders associated with this signaling pathway.

KW - Animal model

KW - Neurodegeneration

KW - Wnt-signaling pathway

KW - Zebrafish

UR - https://www.mendeley.com/catalogue/29653a4e-2597-34f8-a4a6-878aa96c0d3c/

U2 - 10.1016/j.neuroscience.2025.06.003

DO - 10.1016/j.neuroscience.2025.06.003

M3 - Article

VL - 579

SP - 239

EP - 249

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

ER -

ID: 137659274