TY - JOUR

T1 - Developing Peripheral Biochemical Biomarkers of Brain Disorders: Insights from Zebrafish Models

AU - Галстян, Давид Самвелович

AU - Ильин, Никита Петрович

AU - Колесникова, Татьяна Олеговна

AU - Демин, Константин Андреевич

AU - Калуев, Алан Валерьевич

N1 - Ilyin, N.P., Petersen, E.V., Kolesnikova, T.O. et al. Developing Peripheral Biochemical Biomarkers of Brain Disorders: Insights from Zebrafish Models. Biochemistry Moscow 89, 377–391 (2024). https://doi.org/10.1134/S0006297924020160

PY - 2024/3/20

Y1 - 2024/3/20

N2 - High prevalence of human brain disorders necessitates development of the reliable peripheral biomarkers as diagnostic and disease-monitoring tools. In addition to clinical studies, animal models markedly advance studying of non-brain abnormalities associated with brain pathogenesis. The zebrafish (Danio rerio) is becoming increasingly popular as an animal model organism in translational neuroscience. These fish share some practical advantages over mammalian models together with high genetic homology and evolutionarily conserved biochemical and neurobehavioral phenotypes, thus enabling large-scale modeling of human brain diseases. Here, we review mounting evidence on peripheral biomarkers of brain disorders in zebrafish models, focusing on altered biochemistry (lipids, carbohydrates, proteins, and other non-signal molecules, as well as metabolic reactions and activity of enzymes). Collectively, these data strongly support the utility of zebrafish (from a systems biology standpoint) to study peripheral manifestations of brain disorders, as well as highlight potential applications of biochemical biomarkers in zebrafish models to biomarker-based drug discovery and development.

AB - High prevalence of human brain disorders necessitates development of the reliable peripheral biomarkers as diagnostic and disease-monitoring tools. In addition to clinical studies, animal models markedly advance studying of non-brain abnormalities associated with brain pathogenesis. The zebrafish (Danio rerio) is becoming increasingly popular as an animal model organism in translational neuroscience. These fish share some practical advantages over mammalian models together with high genetic homology and evolutionarily conserved biochemical and neurobehavioral phenotypes, thus enabling large-scale modeling of human brain diseases. Here, we review mounting evidence on peripheral biomarkers of brain disorders in zebrafish models, focusing on altered biochemistry (lipids, carbohydrates, proteins, and other non-signal molecules, as well as metabolic reactions and activity of enzymes). Collectively, these data strongly support the utility of zebrafish (from a systems biology standpoint) to study peripheral manifestations of brain disorders, as well as highlight potential applications of biochemical biomarkers in zebrafish models to biomarker-based drug discovery and development.

KW - biomarker

KW - brain disorders

KW - epilepsy

KW - neurodegeneration

KW - peripheral

KW - stress

KW - zebrafish

UR - https://www.mendeley.com/catalogue/9c447202-6dc3-38f9-b7db-bb02fb391971/

U2 - 10.1134/s0006297924020160

DO - 10.1134/s0006297924020160

M3 - Article

VL - 89

SP - 377

EP - 391

JO - Biochemistry (Moscow)

JF - Biochemistry (Moscow)

SN - 0006-2979

IS - 2

ER -