Research output: Contribution to journal › Review article › peer-review
Developing Novel Experimental Models of m-TORopathic Epilepsy and Related Neuropathologies: Translational Insights from Zebrafish. / de Abreu, Murillo; Demin, Konstantin A. ; Maria, Kotova; Mirzaei, Foad; Shariff, Sanobar; Kantawala, Burhan; Zakharchenko, Ksenia; Kolesnikova, Tatiana; Dilbaryan, Karen; Grigoryan, Artem; Yenkoyan, Konstantin; Kalueff , Allan V. .
In: International Journal of Molecular Sciences, Vol. 24, No. 2, 1530, 12.01.2023.Research output: Contribution to journal › Review article › peer-review
}
TY - JOUR
T1 - Developing Novel Experimental Models of m-TORopathic Epilepsy and Related Neuropathologies: Translational Insights from Zebrafish
AU - de Abreu, Murillo
AU - Demin, Konstantin A.
AU - Maria, Kotova
AU - Mirzaei, Foad
AU - Shariff, Sanobar
AU - Kantawala, Burhan
AU - Zakharchenko, Ksenia
AU - Kolesnikova, Tatiana
AU - Dilbaryan, Karen
AU - Grigoryan, Artem
AU - Yenkoyan, Konstantin
AU - Kalueff , Allan V.
PY - 2023/1/12
Y1 - 2023/1/12
N2 - The mammalian target of rapamycin (mTOR) is an important molecular regulator of cell growth and proliferation. Brain mTOR activity plays a crucial role in synaptic plasticity, cell development, migration and proliferation, as well as memory storage, protein synthesis, autophagy, ion channel expression and axonal regeneration. Aberrant mTOR signaling causes a diverse group of neurological disorders, termed ‘mTORopathies’. Typically arising from mutations within the mTOR signaling pathway, these disorders are characterized by cortical malformations and other neuromorphological abnormalities that usually co-occur with severe, often treatment-resistant, epilepsy. Here, we discuss recent advances and current challenges in developing experimental models of mTOR-dependent epilepsy and other related mTORopathies, including using zebrafish models for studying these disorders, as well as outline future directions of research in this field.
AB - The mammalian target of rapamycin (mTOR) is an important molecular regulator of cell growth and proliferation. Brain mTOR activity plays a crucial role in synaptic plasticity, cell development, migration and proliferation, as well as memory storage, protein synthesis, autophagy, ion channel expression and axonal regeneration. Aberrant mTOR signaling causes a diverse group of neurological disorders, termed ‘mTORopathies’. Typically arising from mutations within the mTOR signaling pathway, these disorders are characterized by cortical malformations and other neuromorphological abnormalities that usually co-occur with severe, often treatment-resistant, epilepsy. Here, we discuss recent advances and current challenges in developing experimental models of mTOR-dependent epilepsy and other related mTORopathies, including using zebrafish models for studying these disorders, as well as outline future directions of research in this field.
KW - mTOR
KW - signaling pathway
KW - zebrafish
KW - animal model
KW - mTORopathy
KW - Zebrafish/metabolism
KW - Animals
KW - Signal Transduction
KW - Epilepsy/genetics
KW - Mammals/metabolism
KW - TOR Serine-Threonine Kinases/metabolism
KW - Disease Models, Animal
UR - https://www.mendeley.com/catalogue/6193d2be-6e81-35f3-b26a-d92a54ba22aa/
U2 - 10.3390/ijms24021530
DO - 10.3390/ijms24021530
M3 - Review article
C2 - 36675042
VL - 24
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1422-0067
IS - 2
M1 - 1530
ER -
ID: 102561584