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Developing better and more valid animal models of brain disorders. / Stewart, Adam Michael; Kalueff, Allan V.

In: Behavioural Brain Research, Vol. 276, 01.01.2015, p. 28-31.

Research output: Contribution to journal › Review article › peer-review

Harvard

Stewart, AM & Kalueff, AV 2015, 'Developing better and more valid animal models of brain disorders', Behavioural Brain Research, vol. 276, pp. 28-31. https://doi.org/10.1016/j.bbr.2013.12.024

APA

Stewart, A. M., & Kalueff, A. V. (2015). Developing better and more valid animal models of brain disorders. Behavioural Brain Research, 276, 28-31. https://doi.org/10.1016/j.bbr.2013.12.024

Vancouver

Stewart AM, Kalueff AV. Developing better and more valid animal models of brain disorders. Behavioural Brain Research. 2015 Jan 1;276:28-31. https://doi.org/10.1016/j.bbr.2013.12.024

Author

Stewart, Adam Michael ; Kalueff, Allan V. / Developing better and more valid animal models of brain disorders. In: Behavioural Brain Research. 2015 ; Vol. 276. pp. 28-31.

BibTeX

@article{b5ed584b24574bf398e49d173c9584eb,
title = "Developing better and more valid animal models of brain disorders",
abstract = "Valid sensitive animal models are crucial for understanding the pathobiology of complex human disorders, such as anxiety, autism, depression and schizophrenia, which all have the 'spectrum' nature. Discussing new important strategic directions of research in this field, here we focus i) on cross-species validation of animal models, ii) ensuring their population (external) validity, and iii) the need to target the interplay between multiple disordered domains. We note that optimal animal models of brain disorders should target evolutionary conserved 'core' traits/domains and specifically mimic the clinically relevant inter-relationships between these domains.",
keywords = "Animal model, Biological psychiatry, Domain interplay, Model validity, Translational neuroscience",
author = "Stewart, {Adam Michael} and Kalueff, {Allan V.}",
year = "2015",
month = jan,
day = "1",
doi = "10.1016/j.bbr.2013.12.024",
language = "English",
volume = "276",
pages = "28--31",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Developing better and more valid animal models of brain disorders

AU - Stewart, Adam Michael

AU - Kalueff, Allan V.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Valid sensitive animal models are crucial for understanding the pathobiology of complex human disorders, such as anxiety, autism, depression and schizophrenia, which all have the 'spectrum' nature. Discussing new important strategic directions of research in this field, here we focus i) on cross-species validation of animal models, ii) ensuring their population (external) validity, and iii) the need to target the interplay between multiple disordered domains. We note that optimal animal models of brain disorders should target evolutionary conserved 'core' traits/domains and specifically mimic the clinically relevant inter-relationships between these domains.

AB - Valid sensitive animal models are crucial for understanding the pathobiology of complex human disorders, such as anxiety, autism, depression and schizophrenia, which all have the 'spectrum' nature. Discussing new important strategic directions of research in this field, here we focus i) on cross-species validation of animal models, ii) ensuring their population (external) validity, and iii) the need to target the interplay between multiple disordered domains. We note that optimal animal models of brain disorders should target evolutionary conserved 'core' traits/domains and specifically mimic the clinically relevant inter-relationships between these domains.

KW - Animal model

KW - Biological psychiatry

KW - Domain interplay

KW - Model validity

KW - Translational neuroscience

UR - http://www.scopus.com/inward/record.url?scp=84910068874&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2013.12.024

DO - 10.1016/j.bbr.2013.12.024

M3 - Review article

C2 - 24384129

AN - SCOPUS:84910068874

VL - 276

SP - 28

EP - 31

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

ER -

ID: 9437592