Determination of Zoledronic Acid and Creatinine by Hydrophilic Chromatography

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Determination of Zoledronic Acid and Creatinine by Hydrophilic Chromatography. / Kartsova, L. A.; Somova, V. D.; Bessonova, E. A.

In: Journal of Analytical Chemistry, Vol. 76, No. 2, 02.2021, p. 221-225.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{9fd5c26f3c4f4925800f969ee45a50c4,

title = "Determination of Zoledronic Acid and Creatinine by Hydrophilic Chromatography",

abstract = "We propose a version of the simultaneous determination of zoledronic acid and creatinine in serum and plasma samples by hydrophilic chromatography (HILIC). Factors affecting the determination of zoledronic acid were found: the composition and concentration of the buffer solution, the nature of the stationary phase, the presence of tartaric acid in the eluent as a complexing agent to prevent the complexation of zoledronic acid with metal ions. We determined the linear concentration ranges for zoledronic acid and creatinine and their limits of detection. The following conditions for chromatographic analysis were found: amide stationary phase; a 5 mM phosphate buffer solution, 2 mM tartaric acid (pH 7.0)/CH3CN; gradient 90-70% of CH3CN.",

keywords = "amide stationary phase, complexation, creatinine, hydrophilic chromatography, tartaric acid, zoledronic acid, RETENTION",

author = "Kartsova, {L. A.} and Somova, {V. D.} and Bessonova, {E. A.}",

note = "Kartsova, L.A., Somova, V.D. & Bessonova, E.A. Determination of Zoledronic Acid and Creatinine by Hydrophilic Chromatography. J Anal Chem 76, 221–225 (2021). https://doi.org/10.1134/S1061934821020106",

year = "2021",

month = feb,

doi = "10.1134/s1061934821020106",

language = "English",

volume = "76",

pages = "221--225",

journal = "Journal of Analytical Chemistry",

issn = "1061-9348",

publisher = "МАИК {"}Наука/Интерпериодика{"}",

number = "2",

}

RIS

TY - JOUR

T1 - Determination of Zoledronic Acid and Creatinine by Hydrophilic Chromatography

AU - Kartsova, L. A.

AU - Somova, V. D.

AU - Bessonova, E. A.

N1 - Kartsova, L.A., Somova, V.D. & Bessonova, E.A. Determination of Zoledronic Acid and Creatinine by Hydrophilic Chromatography. J Anal Chem 76, 221–225 (2021). https://doi.org/10.1134/S1061934821020106

PY - 2021/2

Y1 - 2021/2

N2 - We propose a version of the simultaneous determination of zoledronic acid and creatinine in serum and plasma samples by hydrophilic chromatography (HILIC). Factors affecting the determination of zoledronic acid were found: the composition and concentration of the buffer solution, the nature of the stationary phase, the presence of tartaric acid in the eluent as a complexing agent to prevent the complexation of zoledronic acid with metal ions. We determined the linear concentration ranges for zoledronic acid and creatinine and their limits of detection. The following conditions for chromatographic analysis were found: amide stationary phase; a 5 mM phosphate buffer solution, 2 mM tartaric acid (pH 7.0)/CH3CN; gradient 90-70% of CH3CN.

AB - We propose a version of the simultaneous determination of zoledronic acid and creatinine in serum and plasma samples by hydrophilic chromatography (HILIC). Factors affecting the determination of zoledronic acid were found: the composition and concentration of the buffer solution, the nature of the stationary phase, the presence of tartaric acid in the eluent as a complexing agent to prevent the complexation of zoledronic acid with metal ions. We determined the linear concentration ranges for zoledronic acid and creatinine and their limits of detection. The following conditions for chromatographic analysis were found: amide stationary phase; a 5 mM phosphate buffer solution, 2 mM tartaric acid (pH 7.0)/CH3CN; gradient 90-70% of CH3CN.

KW - amide stationary phase

KW - complexation

KW - creatinine

KW - hydrophilic chromatography

KW - tartaric acid

KW - zoledronic acid

KW - RETENTION

UR - http://www.scopus.com/inward/record.url?scp=85101392094&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/1c11c609-1524-3851-b49d-a5bf8af2274c/

U2 - 10.1134/s1061934821020106

DO - 10.1134/s1061934821020106

M3 - Article

AN - SCOPUS:85101392094

VL - 76

SP - 221

EP - 225

JO - Journal of Analytical Chemistry

JF - Journal of Analytical Chemistry

SN - 1061-9348

IS - 2

ER -

ID: 77818644