Design principles of ocular drug delivery systems

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Design principles of ocular drug delivery systems : importance of drug payload, release rate, and material properties. / Subrizi, Astrid; del Amo, Eva M.; Korzhikov-Vlakh, Viktor ; Tennikova, Tatiana; Ruponen, Marika; Urtti, Arto.

In: Drug Discovery Today, Vol. 24, No. 8, 08.2019, p. 1446-1457.

Research output: Contribution to journal › Review article › peer-review

BibTeX

@article{f49b8a70fc574ad2b8f2b443b06aaa4d,

title = "Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties",

abstract = "Ocular drugs are usually delivered locally to the eye. Required drug loading, release rate, and ocular retention time of drug delivery systems depend on the potency, bioavailability, and clearance of the drug at the target site. Drug-loading capacity of the formulation is limited by the material properties and size constraints of the eye. The design aid described herein for ocular drug delivery systems guides the calculation of steady-state drug concentrations in the ocular compartments, taking into account drug dose, bioavailability, and clearance. The dosing rate can be adjusted to reach the target drug concentrations, thereby guiding the design of drug delivery systems for topical, intravitreal, and subconjunctival administration. The simple design aid can be used at early stages of drug development by investigators without expertise in pharmacokinetic and pharmacodynamic modeling. Successful drug delivery to ocular targets depends on ocular biology, drug properties, and formulation characteristics. A multifactorial design aid for ocular drug delivery is presented.",

keywords = "интраокулярная доставка лекарств, RETINAL-PIGMENT EPITHELIUM, HYALURONIC-ACID HYDROGELS, SUSTAINED-RELEASE, IN-VITRO, OPHTHALMIC DELIVERY, POSTERIOR SEGMENT, MOLECULAR-WEIGHT, CIPROFLOXACIN HYDROCHLORIDE, MATRIX METALLOPROTEINASES, PHARMACOKINETIC MODEL",

author = "Astrid Subrizi and {del Amo}, {Eva M.} and Viktor Korzhikov-Vlakh and Tatiana Tennikova and Marika Ruponen and Arto Urtti",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = aug,

doi = "10.1016/j.drudis.2019.02.001",

language = "English",

volume = "24",

pages = "1446--1457",

journal = "Drug Discovery Today",

issn = "1359-6446",

publisher = "Elsevier",

number = "8",

}

RIS

TY - JOUR

T1 - Design principles of ocular drug delivery systems

T2 - importance of drug payload, release rate, and material properties

AU - Subrizi, Astrid

AU - del Amo, Eva M.

AU - Korzhikov-Vlakh, Viktor

AU - Tennikova, Tatiana

AU - Ruponen, Marika

AU - Urtti, Arto

PY - 2019/8

Y1 - 2019/8

N2 - Ocular drugs are usually delivered locally to the eye. Required drug loading, release rate, and ocular retention time of drug delivery systems depend on the potency, bioavailability, and clearance of the drug at the target site. Drug-loading capacity of the formulation is limited by the material properties and size constraints of the eye. The design aid described herein for ocular drug delivery systems guides the calculation of steady-state drug concentrations in the ocular compartments, taking into account drug dose, bioavailability, and clearance. The dosing rate can be adjusted to reach the target drug concentrations, thereby guiding the design of drug delivery systems for topical, intravitreal, and subconjunctival administration. The simple design aid can be used at early stages of drug development by investigators without expertise in pharmacokinetic and pharmacodynamic modeling. Successful drug delivery to ocular targets depends on ocular biology, drug properties, and formulation characteristics. A multifactorial design aid for ocular drug delivery is presented.

AB - Ocular drugs are usually delivered locally to the eye. Required drug loading, release rate, and ocular retention time of drug delivery systems depend on the potency, bioavailability, and clearance of the drug at the target site. Drug-loading capacity of the formulation is limited by the material properties and size constraints of the eye. The design aid described herein for ocular drug delivery systems guides the calculation of steady-state drug concentrations in the ocular compartments, taking into account drug dose, bioavailability, and clearance. The dosing rate can be adjusted to reach the target drug concentrations, thereby guiding the design of drug delivery systems for topical, intravitreal, and subconjunctival administration. The simple design aid can be used at early stages of drug development by investigators without expertise in pharmacokinetic and pharmacodynamic modeling. Successful drug delivery to ocular targets depends on ocular biology, drug properties, and formulation characteristics. A multifactorial design aid for ocular drug delivery is presented.

KW - интраокулярная доставка лекарств

KW - RETINAL-PIGMENT EPITHELIUM

KW - HYALURONIC-ACID HYDROGELS

KW - SUSTAINED-RELEASE

KW - IN-VITRO

KW - OPHTHALMIC DELIVERY

KW - POSTERIOR SEGMENT

KW - MOLECULAR-WEIGHT

KW - CIPROFLOXACIN HYDROCHLORIDE

KW - MATRIX METALLOPROTEINASES

KW - PHARMACOKINETIC MODEL

UR - http://www.scopus.com/inward/record.url?scp=85061607596&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/design-principles-ocular-drug-delivery-systems-importance-drug-payload-release-rate-material-propert

U2 - 10.1016/j.drudis.2019.02.001

DO - 10.1016/j.drudis.2019.02.001

M3 - Review article

AN - SCOPUS:85061607596

VL - 24

SP - 1446

EP - 1457

JO - Drug Discovery Today

JF - Drug Discovery Today

SN - 1359-6446

IS - 8

ER -

ID: 40085114

Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties

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