Design, Fabrication and Characterization of Biodegradable Composites Containing Closo-Borates as Potential Materials for Boron Neutron Capture Therapy

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Design, Fabrication and Characterization of Biodegradable Composites Containing Closo-Borates as Potential Materials for Boron Neutron Capture Therapy. / Stepanova, Mariia A.; Dobrodumov, Anatoliy V.; Averianov, Ilia; Gofman, Iosif V.; Nashchekina , Juliya ; Guryanov , Ivan ; Klyukin, Ilya N.; Zhdanov, Andrey P.; Коржикова-Влах, Евгения Георгиевна; Zhizhin, Konstantin Yu.

In: Polymers, Vol. 14, No. 18, 3864, 15.09.2022.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{7926628547b84d83b7ce85234eabe061,

title = "Design, Fabrication and Characterization of Biodegradable Composites Containing Closo-Borates as Potential Materials for Boron Neutron Capture Therapy",

abstract = "Boron neutron capture therapy (BNCT) has been recognized as a very promising approach for cancer treatment. In the case of osteosarcoma, boron-containing scaffolds can be a powerful tool to combine boron delivery to the tumor cells and the repair of postoperative bone defects. Here we describe the fabrication and characterization of novel biodegradable polymer composites as films and 3D-printed matrices based on aliphatic polyesters containing closo-borates (CB) for BNCT. Different approaches to the fabrication of composites have been applied, and the mechanical properties of these composites, kinetics of their degradation, and the release of closo-borate have been studied. The most complex scaffold was a 3D-printed poly(ε-caprolactone) matrix filled with CB-containing alginate/gelatin hydrogel to enhance biocompatibility. The results obtained allowed us to confirm the high potential of the developed composite materials for application in BNCT and bone tissue regeneration.",

keywords = "closo-borates, Aliphatic polyesters, poly(lactic acid), poly(ε-caprolactone), alginate/gelatin hydrogel, biocompatible 2D and 3D polymer composites, mechanical and degradation properties, drug delivery system for boron neutron capture therapy, aliphatic polyesters",

author = "Stepanova, {Mariia A.} and Dobrodumov, {Anatoliy V.} and Ilia Averianov and Gofman, {Iosif V.} and Juliya Nashchekina and Ivan Guryanov and Klyukin, {Ilya N.} and Zhdanov, {Andrey P.} and Коржикова-Влах, {Евгения Георгиевна} and Zhizhin, {Konstantin Yu.}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = sep,

day = "15",

doi = "10.3390/polym14183864",

language = "English",

volume = "14",

journal = "Polymers",

issn = "2073-4360",

publisher = "MDPI AG",

number = "18",

}

RIS

TY - JOUR

T1 - Design, Fabrication and Characterization of Biodegradable Composites Containing Closo-Borates as Potential Materials for Boron Neutron Capture Therapy

AU - Stepanova, Mariia A.

AU - Dobrodumov, Anatoliy V.

AU - Averianov, Ilia

AU - Gofman, Iosif V.

AU - Nashchekina , Juliya

AU - Guryanov , Ivan

AU - Klyukin, Ilya N.

AU - Zhdanov, Andrey P.

AU - Коржикова-Влах, Евгения Георгиевна

AU - Zhizhin, Konstantin Yu.

PY - 2022/9/15

Y1 - 2022/9/15

N2 - Boron neutron capture therapy (BNCT) has been recognized as a very promising approach for cancer treatment. In the case of osteosarcoma, boron-containing scaffolds can be a powerful tool to combine boron delivery to the tumor cells and the repair of postoperative bone defects. Here we describe the fabrication and characterization of novel biodegradable polymer composites as films and 3D-printed matrices based on aliphatic polyesters containing closo-borates (CB) for BNCT. Different approaches to the fabrication of composites have been applied, and the mechanical properties of these composites, kinetics of their degradation, and the release of closo-borate have been studied. The most complex scaffold was a 3D-printed poly(ε-caprolactone) matrix filled with CB-containing alginate/gelatin hydrogel to enhance biocompatibility. The results obtained allowed us to confirm the high potential of the developed composite materials for application in BNCT and bone tissue regeneration.

AB - Boron neutron capture therapy (BNCT) has been recognized as a very promising approach for cancer treatment. In the case of osteosarcoma, boron-containing scaffolds can be a powerful tool to combine boron delivery to the tumor cells and the repair of postoperative bone defects. Here we describe the fabrication and characterization of novel biodegradable polymer composites as films and 3D-printed matrices based on aliphatic polyesters containing closo-borates (CB) for BNCT. Different approaches to the fabrication of composites have been applied, and the mechanical properties of these composites, kinetics of their degradation, and the release of closo-borate have been studied. The most complex scaffold was a 3D-printed poly(ε-caprolactone) matrix filled with CB-containing alginate/gelatin hydrogel to enhance biocompatibility. The results obtained allowed us to confirm the high potential of the developed composite materials for application in BNCT and bone tissue regeneration.

KW - closo-borates

KW - Aliphatic polyesters

KW - poly(lactic acid)

KW - poly(ε-caprolactone)

KW - alginate/gelatin hydrogel

KW - biocompatible 2D and 3D polymer composites

KW - mechanical and degradation properties

KW - drug delivery system for boron neutron capture therapy

KW - aliphatic polyesters

UR - https://www.mendeley.com/catalogue/6f360aab-ba6b-3a49-a4f8-75017083774f/

UR - http://www.scopus.com/inward/record.url?scp=85138754952&partnerID=8YFLogxK

U2 - 10.3390/polym14183864

DO - 10.3390/polym14183864

M3 - Article

VL - 14

JO - Polymers

JF - Polymers

SN - 2073-4360

IS - 18

M1 - 3864

ER -

ID: 98737455