Demonstration of Physical and Analytical Features of Surface-Enhanced Raman Scattering by Analysis of Folic Acid in Commercial Tablets

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Demonstration of Physical and Analytical Features of Surface-Enhanced Raman Scattering by Analysis of Folic Acid in Commercial Tablets. / Solovyeva, Elena V.; Borisov, Evgenii.

In: Journal of Chemical Education, Vol. 97, No. 8, 11.08.2020, p. 2249-2253.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{9a6c1f51317341ebbdf13aa9b4005c08,

title = "Demonstration of Physical and Analytical Features of Surface-Enhanced Raman Scattering by Analysis of Folic Acid in Commercial Tablets",

abstract = "A novel two-part laboratory demonstration of surface-enhanced Raman scattering (SERS) spectroscopy was successfully implemented for undergraduate and graduate students in physical and analytical chemistry. The first part enables students to understand how the choice of the excitation laser line affects the SERS spectra. It is clearly demonstrated that intense SERS spectra arise only when the wavelength of the excitation line falls into the region of electromagnetic resonance, while the enhancement is negligible under off-resonance conditions. The second part illustrates to the students the analytical benefits of SERS spectroscopy through fast and simple identification of folic acid in a commercial tablet. The presented demonstration is designed to allow students to use silver nanoparticles that they obtained in other related laboratory experiments. Using a well-known drug also stirs up the student's interest and was applied to teaching the SERS method for the first time. Importantly, the demonstration allows students to understand some fundamentals of SERS spectroscopy and at the same time to recognize its practical potential for high-throughput analysis.",

keywords = "Analytical Chemistry, Demonstrations, Drugs/Pharmaceuticals, First-Year Undergraduate/General, Hands-On Learning/Manipulatives, Physical Chemistry, Spectroscopy, Upper-Division Undergraduate, SILVER NANOPARTICLES, SUPPLEMENTATION, SPECTROSCOPY, ORIENTATION, SUBSTRATE, FABRICATION, SWEET NANOCHEMISTRY, COLORANTS",

author = "Solovyeva, {Elena V.} and Evgenii Borisov",

note = "Publisher Copyright: Copyright {\textcopyright} 2020 American Chemical Society and Division of Chemical Education, Inc.",

year = "2020",

month = aug,

day = "11",

doi = "10.1021/acs.jchemed.0c00103",

language = "English",

volume = "97",

pages = "2249--2253",

journal = "Journal of Chemical Education",

issn = "0021-9584",

publisher = "American Chemical Society",

number = "8",

}

RIS

TY - JOUR

T1 - Demonstration of Physical and Analytical Features of Surface-Enhanced Raman Scattering by Analysis of Folic Acid in Commercial Tablets

AU - Solovyeva, Elena V.

AU - Borisov, Evgenii

PY - 2020/8/11

Y1 - 2020/8/11

N2 - A novel two-part laboratory demonstration of surface-enhanced Raman scattering (SERS) spectroscopy was successfully implemented for undergraduate and graduate students in physical and analytical chemistry. The first part enables students to understand how the choice of the excitation laser line affects the SERS spectra. It is clearly demonstrated that intense SERS spectra arise only when the wavelength of the excitation line falls into the region of electromagnetic resonance, while the enhancement is negligible under off-resonance conditions. The second part illustrates to the students the analytical benefits of SERS spectroscopy through fast and simple identification of folic acid in a commercial tablet. The presented demonstration is designed to allow students to use silver nanoparticles that they obtained in other related laboratory experiments. Using a well-known drug also stirs up the student's interest and was applied to teaching the SERS method for the first time. Importantly, the demonstration allows students to understand some fundamentals of SERS spectroscopy and at the same time to recognize its practical potential for high-throughput analysis.

AB - A novel two-part laboratory demonstration of surface-enhanced Raman scattering (SERS) spectroscopy was successfully implemented for undergraduate and graduate students in physical and analytical chemistry. The first part enables students to understand how the choice of the excitation laser line affects the SERS spectra. It is clearly demonstrated that intense SERS spectra arise only when the wavelength of the excitation line falls into the region of electromagnetic resonance, while the enhancement is negligible under off-resonance conditions. The second part illustrates to the students the analytical benefits of SERS spectroscopy through fast and simple identification of folic acid in a commercial tablet. The presented demonstration is designed to allow students to use silver nanoparticles that they obtained in other related laboratory experiments. Using a well-known drug also stirs up the student's interest and was applied to teaching the SERS method for the first time. Importantly, the demonstration allows students to understand some fundamentals of SERS spectroscopy and at the same time to recognize its practical potential for high-throughput analysis.

KW - Analytical Chemistry

KW - Demonstrations

KW - Drugs/Pharmaceuticals

KW - First-Year Undergraduate/General

KW - Hands-On Learning/Manipulatives

KW - Physical Chemistry

KW - Spectroscopy

KW - Upper-Division Undergraduate

KW - SILVER NANOPARTICLES

KW - SUPPLEMENTATION

KW - SPECTROSCOPY

KW - ORIENTATION

KW - SUBSTRATE

KW - FABRICATION

KW - SWEET NANOCHEMISTRY

KW - COLORANTS

UR - http://www.scopus.com/inward/record.url?scp=85088564533&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/537b855a-35a0-3266-8f51-69b41333c583/

U2 - 10.1021/acs.jchemed.0c00103

DO - 10.1021/acs.jchemed.0c00103

M3 - Article

AN - SCOPUS:85088564533

VL - 97

SP - 2249

EP - 2253

JO - Journal of Chemical Education

JF - Journal of Chemical Education

SN - 0021-9584

IS - 8

ER -

ID: 62120523