Macroporous monolithic material containing covalently linked ribonuclease A was used to create high-performance flow heterogeneous biocatalysts (bioreactors). The kinetic parameters of the degradation of polycytidylic acid were identified, and the properties of the obtained systems were compared. A HPLC method has been developed for monitoring products of biocatalytic degradation of RNA, and the possibility of using biocatalytic and HPLC columns in RNA degradation processes in a multicomponent mixture of biological molecules was shown.
Original language | English |
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Pages (from-to) | 629-636 |
Number of pages | 9 |
Journal | Applied Biochemistry and Microbiology |
Volume | 50 |
Issue number | 6 |
DOIs | |
State | Published - 2014 |
ID: 7011442