TY - JOUR

T1 - Decoding Molecular Bases of Rodent Social Hetero-Grooming Behavior Using in Silico Analyses and Bioinformatics Tools

AU - Галстян, Давид Самвелович

AU - Колесникова, Татьяна Олеговна

AU - Калуев, Алан Валерьевич

PY - 2024/8/1

Y1 - 2024/8/1

N2 - Highly prevalent in laboratory rodents, ‘social’ hetero-grooming behavior is translationally relevant to modeling a wide range of neuropsychiatric disorders. Here, we comprehensively evaluated known mouse genes linked to aberrant hetero-grooming phenotype and applied bioinformatics tools to construct a network of their established protein–protein interactions (PPI). We next identified several distinct molecular clusters within this network, including neuronal differentiation, cytoskeletal, WNT-signaling and synapsins-associated pathways. Using additional bioinformatics analyses, we further identified ‘central’ (hub) proteins within these molecular clusters, likely key for mouse hetero-grooming behavior. Overall, a more comprehensive characterization of intricate molecular pathways linked to aberrant rodent grooming may markedly advance our understanding of underlying cellular mechanisms and related neurological disorders, eventually helping discover novel targets for their pharmacological or gene therapy interventions.

AB - Highly prevalent in laboratory rodents, ‘social’ hetero-grooming behavior is translationally relevant to modeling a wide range of neuropsychiatric disorders. Here, we comprehensively evaluated known mouse genes linked to aberrant hetero-grooming phenotype and applied bioinformatics tools to construct a network of their established protein–protein interactions (PPI). We next identified several distinct molecular clusters within this network, including neuronal differentiation, cytoskeletal, WNT-signaling and synapsins-associated pathways. Using additional bioinformatics analyses, we further identified ‘central’ (hub) proteins within these molecular clusters, likely key for mouse hetero-grooming behavior. Overall, a more comprehensive characterization of intricate molecular pathways linked to aberrant rodent grooming may markedly advance our understanding of underlying cellular mechanisms and related neurological disorders, eventually helping discover novel targets for their pharmacological or gene therapy interventions.

UR - https://www.mendeley.com/catalogue/dd69d5e7-d647-300a-b3a3-6bcace8a7cdb/

U2 - 10.1016/j.neuroscience.2024.06.004

DO - 10.1016/j.neuroscience.2024.06.004

M3 - Article

VL - 554

SP - 146

EP - 155

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

ER -