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DARK Classics in Chemical Neuroscience : Arecoline. / Volgin, Andrey D.; Bashirzade, Alim; Amstislavskaya, Tamara G.; Yakovlev, Oleg A.; Demin, Konstantin A.; Ho, Ying Jui; Wang, Dongmei; Shevyrin, Vadim A.; Yan, Dongni; Tang, Zhichong; Wang, Jingtao; Wang, Mengyao; Alpyshov, Erik T.; Serikuly, Nazar; Wappler-Guzzetta, Edina A.; Lakstygal, Anton M.; Kalueff, Allan V.

In: ACS Chemical Neuroscience, Vol. 10, No. 5, 15.05.2019, p. 2176-2185.

Research output: Contribution to journal › Review article › peer-review

Harvard

Volgin, AD, Bashirzade, A, Amstislavskaya, TG, Yakovlev, OA, Demin, KA, Ho, YJ, Wang, D, Shevyrin, VA, Yan, D, Tang, Z, Wang, J, Wang, M, Alpyshov, ET, Serikuly, N, Wappler-Guzzetta, EA, Lakstygal, AM & Kalueff, AV 2019, 'DARK Classics in Chemical Neuroscience: Arecoline', ACS Chemical Neuroscience, vol. 10, no. 5, pp. 2176-2185. https://doi.org/10.1021/acschemneuro.8b00711

APA

Volgin, A. D., Bashirzade, A., Amstislavskaya, T. G., Yakovlev, O. A., Demin, K. A., Ho, Y. J., Wang, D., Shevyrin, V. A., Yan, D., Tang, Z., Wang, J., Wang, M., Alpyshov, E. T., Serikuly, N., Wappler-Guzzetta, E. A., Lakstygal, A. M., & Kalueff, A. V. (2019). DARK Classics in Chemical Neuroscience: Arecoline. ACS Chemical Neuroscience, 10(5), 2176-2185. https://doi.org/10.1021/acschemneuro.8b00711

Vancouver

Volgin AD, Bashirzade A, Amstislavskaya TG, Yakovlev OA, Demin KA, Ho YJ et al. DARK Classics in Chemical Neuroscience: Arecoline. ACS Chemical Neuroscience. 2019 May 15;10(5):2176-2185. https://doi.org/10.1021/acschemneuro.8b00711

Author

Volgin, Andrey D. ; Bashirzade, Alim ; Amstislavskaya, Tamara G. ; Yakovlev, Oleg A. ; Demin, Konstantin A. ; Ho, Ying Jui ; Wang, Dongmei ; Shevyrin, Vadim A. ; Yan, Dongni ; Tang, Zhichong ; Wang, Jingtao ; Wang, Mengyao ; Alpyshov, Erik T. ; Serikuly, Nazar ; Wappler-Guzzetta, Edina A. ; Lakstygal, Anton M. ; Kalueff, Allan V. / DARK Classics in Chemical Neuroscience : Arecoline. In: ACS Chemical Neuroscience. 2019 ; Vol. 10, No. 5. pp. 2176-2185.

BibTeX

@article{24284a4c68ec4bfcb7a3df1bce061f1d,
title = "DARK Classics in Chemical Neuroscience: Arecoline",
abstract = "Arecoline is a naturally occurring psychoactive alkaloid from areca (betel) nuts of the areca palm (Areca catechu) endemic to South and Southeast Asia. A partial agonist of nicotinic and muscarinic acetylcholine receptors, arecoline evokes multiple effects on the central nervous system (CNS), including stimulation, alertness, elation, and anxiolysis. Like nicotine, arecoline also evokes addiction and withdrawal symptoms (upon discontinuation). The abuse of areca nuts is widespread, with over 600 million users globally. The importance of arecoline is further supported by its being the world's fourth most commonly used human psychoactive substance (after alcohol, nicotine, and caffeine). Here, we discuss neuropharmacology, pharmacokinetics, and metabolism of arecoline, as well as social and historical aspects of its use and abuse. Paralleling clinical findings, we also evaluate its effects in animal models and outline future clinical and preclinical CNS research in this field.",
keywords = "alkaloid, animal models, Arecoline, clinical effects, nicotine-like action, ZEBRAFISH, RAT, DRUG DISCOVERY, MOUSE, ARECA NUT USE, PREVALENCE, BETEL QUID CARCINOGENESIS, N-OXIDE, PHARMACOLOGY, STRESS",
author = "Volgin, {Andrey D.} and Alim Bashirzade and Amstislavskaya, {Tamara G.} and Yakovlev, {Oleg A.} and Demin, {Konstantin A.} and Ho, {Ying Jui} and Dongmei Wang and Shevyrin, {Vadim A.} and Dongni Yan and Zhichong Tang and Jingtao Wang and Mengyao Wang and Alpyshov, {Erik T.} and Nazar Serikuly and Wappler-Guzzetta, {Edina A.} and Lakstygal, {Anton M.} and Kalueff, {Allan V.}",
year = "2019",
month = may,
day = "15",
doi = "10.1021/acschemneuro.8b00711",
language = "English",
volume = "10",
pages = "2176--2185",
journal = "ACS Chemical Neuroscience",
issn = "1948-7193",
publisher = "American Chemical Society",
number = "5",

}

RIS

TY - JOUR

T1 - DARK Classics in Chemical Neuroscience

T2 - Arecoline

AU - Volgin, Andrey D.

AU - Bashirzade, Alim

AU - Amstislavskaya, Tamara G.

AU - Yakovlev, Oleg A.

AU - Demin, Konstantin A.

AU - Ho, Ying Jui

AU - Wang, Dongmei

AU - Shevyrin, Vadim A.

AU - Yan, Dongni

AU - Tang, Zhichong

AU - Wang, Jingtao

AU - Wang, Mengyao

AU - Alpyshov, Erik T.

AU - Serikuly, Nazar

AU - Wappler-Guzzetta, Edina A.

AU - Lakstygal, Anton M.

AU - Kalueff, Allan V.

PY - 2019/5/15

Y1 - 2019/5/15

N2 - Arecoline is a naturally occurring psychoactive alkaloid from areca (betel) nuts of the areca palm (Areca catechu) endemic to South and Southeast Asia. A partial agonist of nicotinic and muscarinic acetylcholine receptors, arecoline evokes multiple effects on the central nervous system (CNS), including stimulation, alertness, elation, and anxiolysis. Like nicotine, arecoline also evokes addiction and withdrawal symptoms (upon discontinuation). The abuse of areca nuts is widespread, with over 600 million users globally. The importance of arecoline is further supported by its being the world's fourth most commonly used human psychoactive substance (after alcohol, nicotine, and caffeine). Here, we discuss neuropharmacology, pharmacokinetics, and metabolism of arecoline, as well as social and historical aspects of its use and abuse. Paralleling clinical findings, we also evaluate its effects in animal models and outline future clinical and preclinical CNS research in this field.

AB - Arecoline is a naturally occurring psychoactive alkaloid from areca (betel) nuts of the areca palm (Areca catechu) endemic to South and Southeast Asia. A partial agonist of nicotinic and muscarinic acetylcholine receptors, arecoline evokes multiple effects on the central nervous system (CNS), including stimulation, alertness, elation, and anxiolysis. Like nicotine, arecoline also evokes addiction and withdrawal symptoms (upon discontinuation). The abuse of areca nuts is widespread, with over 600 million users globally. The importance of arecoline is further supported by its being the world's fourth most commonly used human psychoactive substance (after alcohol, nicotine, and caffeine). Here, we discuss neuropharmacology, pharmacokinetics, and metabolism of arecoline, as well as social and historical aspects of its use and abuse. Paralleling clinical findings, we also evaluate its effects in animal models and outline future clinical and preclinical CNS research in this field.

KW - alkaloid

KW - animal models

KW - Arecoline

KW - clinical effects

KW - nicotine-like action

KW - ZEBRAFISH

KW - RAT

KW - DRUG DISCOVERY

KW - MOUSE

KW - ARECA NUT USE

KW - PREVALENCE

KW - BETEL QUID CARCINOGENESIS

KW - N-OXIDE

KW - PHARMACOLOGY

KW - STRESS

UR - http://www.scopus.com/inward/record.url?scp=85062369621&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/dark-classics-chemical-neuroscience-arecoline

U2 - 10.1021/acschemneuro.8b00711

DO - 10.1021/acschemneuro.8b00711

M3 - Review article

C2 - 30664352

AN - SCOPUS:85062369621

VL - 10

SP - 2176

EP - 2185

JO - ACS Chemical Neuroscience

JF - ACS Chemical Neuroscience

SN - 1948-7193

IS - 5

ER -

ID: 47608216