Research output: Contribution to journal › Article › peer-review
Cytogenetic effect of pheromones on bone marrow cells of male house mice Mus musculus L. / Daev, E. V.; Sverdlova, O. L.; Matskevich, O. A.; Antonyuk, E. V.
In: Genetika, Vol. 31, No. 5, 01.01.1995, p. 632-636.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Cytogenetic effect of pheromones on bone marrow cells of male house mice Mus musculus L.
AU - Daev, E. V.
AU - Sverdlova, O. L.
AU - Matskevich, O. A.
AU - Antonyuk, E. V.
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Young male CBA/LacStoRap mice were exposed for two hours to volatile components of native or dialyzed urine (VC or VC(d), respectively) of mature males of the same line. To estimate the effects of VC and VC(d) on bone marrow cells, cytogenetic analysis of mitotic disturbances in anaphase-telophase cells was performed. The overall-frequency of mitotic disturbances in VC-treated mice became significantly higher 24 and 48 h after exposure but returned to the initial level 72 h after exposure (P < 0.05). Similar effects were observed after 24 h in mice exposed to VC(d). These results suggest that VC and VC(d) are capable of disturbing the stability of genetic processes in proliferating bone marrow cells. Evidence was also obtained that these components are associated with major urinary proteins. The significance and possible mechanisms of effects observed in the study are discussed.
AB - Young male CBA/LacStoRap mice were exposed for two hours to volatile components of native or dialyzed urine (VC or VC(d), respectively) of mature males of the same line. To estimate the effects of VC and VC(d) on bone marrow cells, cytogenetic analysis of mitotic disturbances in anaphase-telophase cells was performed. The overall-frequency of mitotic disturbances in VC-treated mice became significantly higher 24 and 48 h after exposure but returned to the initial level 72 h after exposure (P < 0.05). Similar effects were observed after 24 h in mice exposed to VC(d). These results suggest that VC and VC(d) are capable of disturbing the stability of genetic processes in proliferating bone marrow cells. Evidence was also obtained that these components are associated with major urinary proteins. The significance and possible mechanisms of effects observed in the study are discussed.
UR - http://www.scopus.com/inward/record.url?scp=0029157612&partnerID=8YFLogxK
M3 - статья
C2 - 7622027
AN - SCOPUS:0029157612
VL - 31
SP - 632
EP - 636
JO - ГЕНЕТИКА
JF - ГЕНЕТИКА
SN - 0016-6758
IS - 5
ER -
ID: 42209545