The reaction of benzamidines with 2-bromo- and 2-iodobenzaldehydes catalyzed by the CuI/L-proline system has been studied. Reaction with 2-iodobenzaldehyde leads to the formation of quinazolines in good yield. 2-Bromobenzaldehyde forms 2-arylquinazolines in low yield due to the competing reaction involving two molecules of amidine leading to a dihydrotriazine.

Original languageEnglish
Pages (from-to)1481-1485
Number of pages5
JournalChemistry of Heterocyclic Compounds
Volume46
Issue number12
DOIs
StatePublished - 1 Mar 2011

    Research areas

  • 2-iodobenzaldehyde, benzamidine, catalysis by copper(I), quinazoline

    Scopus subject areas

  • Organic Chemistry

ID: 36261431