The development of the promising new field of sensor applications, multisensor arrays for liquid analysis based on the principles of the electronic tongue, implies some new demands on sensor material research and development. Stable and reproducible sensors with partial specificity and considerable cross-sensitivities to different components in solutions are of primary interest. Solid-state potentiometric sensors, both crystalline and vitreous, are likely to be the most promising ones for multisensor devices designed for long-term analytical application in natural and artificial complex media. The present paper deals with development of a method of evaluation of integral heavy metal cation sensitivity of solid-state sensors with special consideration of cross-sensitivity features. The method involves a comparative study of different sensor materials in individual component solutions, using several criteria based on integral response parameters. The procedure scheme can be applied to evaluate cross-sensitivity of any kind of potentiometric sensors for liquid media.