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Critical view on drug dissolution in artificial saliva: A possible use of in-line e-tongue measurements. / Khaydukova, M.; Kirsanov, D.; Pein-Hackelbusch, M.; Immohr, L.I.; Gilemkhanova, V.; Legin, A.

In: European Journal of Pharmaceutical Sciences, Vol. 99, 2017, p. 266-271.

Research output: Contribution to journal › Article › peer-review

Harvard

Khaydukova, M, Kirsanov, D, Pein-Hackelbusch, M, Immohr, LI, Gilemkhanova, V & Legin, A 2017, 'Critical view on drug dissolution in artificial saliva: A possible use of in-line e-tongue measurements', European Journal of Pharmaceutical Sciences, vol. 99, pp. 266-271. https://doi.org/10.1016/j.ejps.2016.12.028, https://doi.org/10.1016/j.ejps.2016.12.028

APA

Khaydukova, M., Kirsanov, D., Pein-Hackelbusch, M., Immohr, L. I., Gilemkhanova, V., & Legin, A. (2017). Critical view on drug dissolution in artificial saliva: A possible use of in-line e-tongue measurements. European Journal of Pharmaceutical Sciences, 99, 266-271. https://doi.org/10.1016/j.ejps.2016.12.028, https://doi.org/10.1016/j.ejps.2016.12.028

Vancouver

Khaydukova M, Kirsanov D, Pein-Hackelbusch M, Immohr LI, Gilemkhanova V, Legin A. Critical view on drug dissolution in artificial saliva: A possible use of in-line e-tongue measurements. European Journal of Pharmaceutical Sciences. 2017;99:266-271. https://doi.org/10.1016/j.ejps.2016.12.028, https://doi.org/10.1016/j.ejps.2016.12.028

Author

Khaydukova, M. ; Kirsanov, D. ; Pein-Hackelbusch, M. ; Immohr, L.I. ; Gilemkhanova, V. ; Legin, A. / Critical view on drug dissolution in artificial saliva: A possible use of in-line e-tongue measurements. In: European Journal of Pharmaceutical Sciences. 2017 ; Vol. 99. pp. 266-271.

BibTeX

@article{44f193e0fcc2475da5c5c303b0e45e25,
title = "Critical view on drug dissolution in artificial saliva: A possible use of in-line e-tongue measurements",
abstract = "{\textcopyright} 2016 Elsevier B.V.Proper monitoring of drug's dissolution is a prerequisite for assessing of taste masking efficacy of pharmaceuticals. Corresponding dissolution procedure is likely to be performed with water. Since the objective of these tests is to examine fate of a pharmaceutical formulation in oral cavity, this choice of solvent seems unsuitable because physical and chemical properties of human saliva are quite far from those of water. Obviously, dissolution profiles registered in water may differ significantly from what really happens with a drug in a mouth cavity. In order to address this discrepancy we examined three different compositions of artificial saliva in dissolution test context in present study. It was found that certain compositions preclude the employment of traditional UV–vis spectroscopy as a detection tool due to strong light scattering in the media caused by viscosity and protein composition modifiers. This issue was circumvented by the use of in-line applied potentiometric multisenso",
author = "M. Khaydukova and D. Kirsanov and M. Pein-Hackelbusch and L.I. Immohr and V. Gilemkhanova and A. Legin",
year = "2017",
doi = "10.1016/j.ejps.2016.12.028",
language = "English",
volume = "99",
pages = "266--271",
journal = "European Journal of Pharmaceutical Sciences",
issn = "0928-0987",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Critical view on drug dissolution in artificial saliva: A possible use of in-line e-tongue measurements

AU - Khaydukova, M.

AU - Kirsanov, D.

AU - Pein-Hackelbusch, M.

AU - Immohr, L.I.

AU - Gilemkhanova, V.

AU - Legin, A.

PY - 2017

Y1 - 2017

N2 - © 2016 Elsevier B.V.Proper monitoring of drug's dissolution is a prerequisite for assessing of taste masking efficacy of pharmaceuticals. Corresponding dissolution procedure is likely to be performed with water. Since the objective of these tests is to examine fate of a pharmaceutical formulation in oral cavity, this choice of solvent seems unsuitable because physical and chemical properties of human saliva are quite far from those of water. Obviously, dissolution profiles registered in water may differ significantly from what really happens with a drug in a mouth cavity. In order to address this discrepancy we examined three different compositions of artificial saliva in dissolution test context in present study. It was found that certain compositions preclude the employment of traditional UV–vis spectroscopy as a detection tool due to strong light scattering in the media caused by viscosity and protein composition modifiers. This issue was circumvented by the use of in-line applied potentiometric multisenso

AB - © 2016 Elsevier B.V.Proper monitoring of drug's dissolution is a prerequisite for assessing of taste masking efficacy of pharmaceuticals. Corresponding dissolution procedure is likely to be performed with water. Since the objective of these tests is to examine fate of a pharmaceutical formulation in oral cavity, this choice of solvent seems unsuitable because physical and chemical properties of human saliva are quite far from those of water. Obviously, dissolution profiles registered in water may differ significantly from what really happens with a drug in a mouth cavity. In order to address this discrepancy we examined three different compositions of artificial saliva in dissolution test context in present study. It was found that certain compositions preclude the employment of traditional UV–vis spectroscopy as a detection tool due to strong light scattering in the media caused by viscosity and protein composition modifiers. This issue was circumvented by the use of in-line applied potentiometric multisenso

U2 - 10.1016/j.ejps.2016.12.028

DO - 10.1016/j.ejps.2016.12.028

M3 - Article

VL - 99

SP - 266

EP - 271

JO - European Journal of Pharmaceutical Sciences

JF - European Journal of Pharmaceutical Sciences

SN - 0928-0987

ER -

ID: 7908128