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Corticospinal neuroprostheses to restore locomotion after spinal cord injury. / Borton, David; Bonizzato, Marco; Beauparlant, Janine; DiGiovanna, Jack; Moraud, Eduardo M.; Wenger, Nikolaus; Musienko, Pavel; Minev, Ivan R.; Lacour, Stéphanie P.; Millán, José del R.; Micera, Silvestro; Courtine, Grégoire.

In: Neuroscience Research, Vol. 78, No. 1, 01.2014, p. 21-29.

Research output: Contribution to journal › Review article › peer-review

Harvard

Borton, D, Bonizzato, M, Beauparlant, J, DiGiovanna, J, Moraud, EM, Wenger, N, Musienko, P, Minev, IR, Lacour, SP, Millán, JDR, Micera, S & Courtine, G 2014, 'Corticospinal neuroprostheses to restore locomotion after spinal cord injury', Neuroscience Research, vol. 78, no. 1, pp. 21-29. https://doi.org/10.1016/j.neures.2013.10.001

APA

Borton, D., Bonizzato, M., Beauparlant, J., DiGiovanna, J., Moraud, E. M., Wenger, N., Musienko, P., Minev, I. R., Lacour, S. P., Millán, J. D. R., Micera, S., & Courtine, G. (2014). Corticospinal neuroprostheses to restore locomotion after spinal cord injury. Neuroscience Research, 78(1), 21-29. https://doi.org/10.1016/j.neures.2013.10.001

Vancouver

Borton D, Bonizzato M, Beauparlant J, DiGiovanna J, Moraud EM, Wenger N et al. Corticospinal neuroprostheses to restore locomotion after spinal cord injury. Neuroscience Research. 2014 Jan;78(1):21-29. https://doi.org/10.1016/j.neures.2013.10.001

Author

Borton, David ; Bonizzato, Marco ; Beauparlant, Janine ; DiGiovanna, Jack ; Moraud, Eduardo M. ; Wenger, Nikolaus ; Musienko, Pavel ; Minev, Ivan R. ; Lacour, Stéphanie P. ; Millán, José del R. ; Micera, Silvestro ; Courtine, Grégoire. / Corticospinal neuroprostheses to restore locomotion after spinal cord injury. In: Neuroscience Research. 2014 ; Vol. 78, No. 1. pp. 21-29.

BibTeX

@article{dfe1c8e0b289493fa66a72e5179350c1,
title = "Corticospinal neuroprostheses to restore locomotion after spinal cord injury",
abstract = "In this conceptual review, we highlight our strategy for, and progress in the development of corticospinal neuroprostheses for restoring locomotor functions and promoting neural repair after thoracic spinal cord injury in experimental animal models. We specifically focus on recent developments in recording and stimulating neural interfaces, decoding algorithms, extraction of real-time feedback information, and closed-loop control systems. Each of these complex neurotechnologies plays a significant role for the design of corticospinal neuroprostheses. Even more challenging is the coordinated integration of such multifaceted technologies into effective and practical neuroprosthetic systems to improve movement execution, and augment neural plasticity after injury. In this review we address our progress in rodent animal models to explore the viability of a technology-intensive strategy for recovery and repair of the damaged nervous system. The technical, practical, and regulatory hurdles that lie ahead along the path toward clinical applications are enormous - and their resolution is uncertain at this stage. However, it is imperative that the discoveries and technological developments being made across the field of neuroprosthetics do not stay in the lab, but instead reach clinical fruition at the fastest pace possible.",
keywords = "Brain-machine interface, Neuromotor rehabilitation, Neuroprosthetics, Spinal interface",
author = "David Borton and Marco Bonizzato and Janine Beauparlant and Jack DiGiovanna and Moraud, {Eduardo M.} and Nikolaus Wenger and Pavel Musienko and Minev, {Ivan R.} and Lacour, {St{\'e}phanie P.} and Mill{\'a}n, {Jos{\'e} del R.} and Silvestro Micera and Gr{\'e}goire Courtine",
note = "Funding Information: David Borton is supported by a Marie Curie International Incoming Fellowship (IIF, e-Walk #331602). The work mentioned here is also supported by a Starting Grant from the European Research Council to Gr{\'e}goire Courtine ( ERC 261247 , Walk Again), European Community's Seventh Framework Program ( CP-IP 258654 , NeuWALK), NCCR Robotics , and funding from the NanoTera.ch program of the Swiss National Science Foundation (SpineRepair).",
year = "2014",
month = jan,
doi = "10.1016/j.neures.2013.10.001",
language = "English",
volume = "78",
pages = "21--29",
journal = "Neuroscience Research",
issn = "0168-0102",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Corticospinal neuroprostheses to restore locomotion after spinal cord injury

AU - Borton, David

AU - Bonizzato, Marco

AU - Beauparlant, Janine

AU - DiGiovanna, Jack

AU - Moraud, Eduardo M.

AU - Wenger, Nikolaus

AU - Musienko, Pavel

AU - Minev, Ivan R.

AU - Lacour, Stéphanie P.

AU - Millán, José del R.

AU - Micera, Silvestro

AU - Courtine, Grégoire

N1 - Funding Information: David Borton is supported by a Marie Curie International Incoming Fellowship (IIF, e-Walk #331602). The work mentioned here is also supported by a Starting Grant from the European Research Council to Grégoire Courtine ( ERC 261247 , Walk Again), European Community's Seventh Framework Program ( CP-IP 258654 , NeuWALK), NCCR Robotics , and funding from the NanoTera.ch program of the Swiss National Science Foundation (SpineRepair).

PY - 2014/1

Y1 - 2014/1

N2 - In this conceptual review, we highlight our strategy for, and progress in the development of corticospinal neuroprostheses for restoring locomotor functions and promoting neural repair after thoracic spinal cord injury in experimental animal models. We specifically focus on recent developments in recording and stimulating neural interfaces, decoding algorithms, extraction of real-time feedback information, and closed-loop control systems. Each of these complex neurotechnologies plays a significant role for the design of corticospinal neuroprostheses. Even more challenging is the coordinated integration of such multifaceted technologies into effective and practical neuroprosthetic systems to improve movement execution, and augment neural plasticity after injury. In this review we address our progress in rodent animal models to explore the viability of a technology-intensive strategy for recovery and repair of the damaged nervous system. The technical, practical, and regulatory hurdles that lie ahead along the path toward clinical applications are enormous - and their resolution is uncertain at this stage. However, it is imperative that the discoveries and technological developments being made across the field of neuroprosthetics do not stay in the lab, but instead reach clinical fruition at the fastest pace possible.

AB - In this conceptual review, we highlight our strategy for, and progress in the development of corticospinal neuroprostheses for restoring locomotor functions and promoting neural repair after thoracic spinal cord injury in experimental animal models. We specifically focus on recent developments in recording and stimulating neural interfaces, decoding algorithms, extraction of real-time feedback information, and closed-loop control systems. Each of these complex neurotechnologies plays a significant role for the design of corticospinal neuroprostheses. Even more challenging is the coordinated integration of such multifaceted technologies into effective and practical neuroprosthetic systems to improve movement execution, and augment neural plasticity after injury. In this review we address our progress in rodent animal models to explore the viability of a technology-intensive strategy for recovery and repair of the damaged nervous system. The technical, practical, and regulatory hurdles that lie ahead along the path toward clinical applications are enormous - and their resolution is uncertain at this stage. However, it is imperative that the discoveries and technological developments being made across the field of neuroprosthetics do not stay in the lab, but instead reach clinical fruition at the fastest pace possible.

KW - Brain-machine interface

KW - Neuromotor rehabilitation

KW - Neuroprosthetics

KW - Spinal interface

UR - http://www.scopus.com/inward/record.url?scp=84892673750&partnerID=8YFLogxK

U2 - 10.1016/j.neures.2013.10.001

DO - 10.1016/j.neures.2013.10.001

M3 - Review article

C2 - 24135130

AN - SCOPUS:84892673750

VL - 78

SP - 21

EP - 29

JO - Neuroscience Research

JF - Neuroscience Research

SN - 0168-0102

IS - 1

ER -

ID: 92594296