TY - JOUR

T1 - Correlation of the postoperative complications with the predicted pulmonary function after pneumonectomy in pulmonary tuberculosis patients

AU - Denisova, Nina

AU - Kiryukhina, Larisa

AU - Nefedova, Natalia

AU - Kovaleva, Sofia

AU - Kokorina, Elena

AU - Avetisyan, Armen

AU - Sokolovich, Evgeny

AU - Yablonskii, Pyotr

PY - 2020

Y1 - 2020

N2 - Predicted functional respiratory parameters are an important predictor of the postoperative lung morbidity and mortality. But their predictive value for lung resection in pulmonary tuberculosis (PT) remains unstudied. This study assessed a predicted pulmonary function changes effect on the pulmonary complications after pneumonectomy (PE) in PT patients. Methods: 85 patients after PE (57M/28F, mean age 43.1±11.6 yes) in complex PT treatment were evaluated with complex preoperative measurements of FEV1, TLC, VC, RV, FRCpleth and DLCO. The predicted postoperative (ppo) values were compared with the postoperative complications as per R.J. Korst, duration of the operation and intubation, and the additional medical treatment in the first postoperative week. Results: Life-threatening surgical (intrapleural bleeding, hemothorax) and pulmonary (acute respiratory distress syndrome) complications were negatively associated with ppo FEV1 (r=-0.39, p<0.05) and positively associated with ppo TLC, RV, FRCpleth (r=0.53, 0.54, 0.63 respectively, p<0.05). The duration of the operation and intubation were also correlated with ppo VC (r=-0.43 and -0.45, p<0.05), FEV1 (r=-0.59 and -0.48, p<0.05) and FRCpleth (r=0.35 and 0.36, p<0.05). There was also a link between the need to prescribe glucocorticosteroids in the first days after surgery and ppo DLCO and DLCO/AO (rs=-0.29, -0.36, respectively, p<0.05). Conclusions: It was determined that pulmonary complications occurred much more frequently at low ppo values of FEV1 and DLCO and high RV and FRCpleth. Calculating their prognostic values after PE may be especially useful in PT patients with lung function disorders.

AB - Predicted functional respiratory parameters are an important predictor of the postoperative lung morbidity and mortality. But their predictive value for lung resection in pulmonary tuberculosis (PT) remains unstudied. This study assessed a predicted pulmonary function changes effect on the pulmonary complications after pneumonectomy (PE) in PT patients. Methods: 85 patients after PE (57M/28F, mean age 43.1±11.6 yes) in complex PT treatment were evaluated with complex preoperative measurements of FEV1, TLC, VC, RV, FRCpleth and DLCO. The predicted postoperative (ppo) values were compared with the postoperative complications as per R.J. Korst, duration of the operation and intubation, and the additional medical treatment in the first postoperative week. Results: Life-threatening surgical (intrapleural bleeding, hemothorax) and pulmonary (acute respiratory distress syndrome) complications were negatively associated with ppo FEV1 (r=-0.39, p<0.05) and positively associated with ppo TLC, RV, FRCpleth (r=0.53, 0.54, 0.63 respectively, p<0.05). The duration of the operation and intubation were also correlated with ppo VC (r=-0.43 and -0.45, p<0.05), FEV1 (r=-0.59 and -0.48, p<0.05) and FRCpleth (r=0.35 and 0.36, p<0.05). There was also a link between the need to prescribe glucocorticosteroids in the first days after surgery and ppo DLCO and DLCO/AO (rs=-0.29, -0.36, respectively, p<0.05). Conclusions: It was determined that pulmonary complications occurred much more frequently at low ppo values of FEV1 and DLCO and high RV and FRCpleth. Calculating their prognostic values after PE may be especially useful in PT patients with lung function disorders.

UR - https://erj.ersjournals.com/content/56/suppl_64/1710

M3 - Meeting Abstract

VL - 56

SP - 1710

JO - European Respiratory Journal, Supplement

JF - European Respiratory Journal, Supplement

SN - 0904-1850

IS - S64

T2 - ERS International Congress 2021

Y2 - 5 September 2021 through 8 September 2021

ER -