The purpose of this study was to evaluate the clinical efficiency of desmopressine and diclofenac in in-continent patients with nocturnal polyuria and polyuria. A total of 277 patients ≥18 ≤ 55 years of age with complaints of urinary incontinence were included. 143 women had stress incontinence, 43 — urge incontinence and 91 — mixed incontinence. The overall prevalence of nocturia was 34.7 ± 2.9% (96 wo-men). The frequency of poliuriya was 7 ± 2.1 % in stress incontinence, 11.6 ± 4.9 % in urge incon-tinence and 9.9 ± 3.1 % in mixed incontinence (p > 0.05). The frequency of nocturnal polyuria was 17.5 ± 3.2% in stress incontinence, 27.9 ± 6.8% in urge incontinence and 25.3 ± 4.6 % mixed incon-tinence (p > 0.05). Patients were randomized to receive either desmopressin or diclofenac in a dou-ble — blind fashion. The statistically significant recovery of renal function occurred in 8 incontinent women with polyuria and 19 with nocturnal polyuria who received diclofenac and in 12 incontinent women with polyuria and 18 with nocturnal polyuria who received desmopressin (Minirin).