Corifollitropin alfa for ovarian stimulation in in vitro fertilization in women of advanced maternal age

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Corifollitropin alfa for ovarian stimulation in in vitro fertilization in women of advanced maternal age. / Yakovlev, P. P.; Kogan, I. Yu ; Gzgzyan, A. M.; Andreeva, N. Yu.

In: Russian Journal of Human Reproduction, Vol. 25, No. 5, 2019, p. 92-99.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{55ffc191fde64f94af55f6c428e71392,

title = "Corifollitropin alfa for ovarian stimulation in in vitro fertilization in women of advanced maternal age",

abstract = "The purpose of the study is to compare the effectiveness of IVF protocols with the use of corinollitropin alfa in women of advanced maternal age, depending on the ovarian reserve. Material and methods. Retrospective trial of infertile women (n=88) undergoing a single IVF/ICSI cycle with corifollitropin alfa. Depending on the age and state of the ovarian reserve, 3 groups of patients are formed. Group I (n=24) consisted of 37—42 years old women with a low ovarian reserve; group II (n=25) included patients of the same age with a normal ovarian reserve; the comparison group III (n=39) was formed from women 28—36 years with a normal ovarian reserve. Embryo transfer was performed in a fresh IVF cycle using GnRH antagonists protocols. Results. The duration of additional stimulation (from the 8th day of controlled ovarian stimulation) in I group was 6 (1—9), in II 3 (1—8) and in III 2 (1—4) days (pI—III = 0.016; pII—-III =0.171). The total dose of additional stimulation of r-FSH in I group was 1687 (275—2650), in II 675 (200—1950) and in III 450 (225—750) IU, (pI—III = 0.005; pII—III = 0.118). The dose of gonadotropins per 1 oocyte in group I was 1433 (748—2375), in II — 813 (506—900) and in III — 321 (192—386) IU (pI—III/pII—III <0.001). Percentage of mature oocytes (p=0.987) and fertilization rate (p=0.703) did not differ among groups. The frequency of biochemical pregnancy on ET in groups I, II, and III was 6.25, 25.5 and 36.4%, respectively (pI—III =0.037; pII—III = 0.548). The frequency of clinical pregnancies on ET in group I was 6.25%, in group II 17.6% and in group III 36.4% (pI—III = 0.037; pII—III =0.297). Conclusion. The use of fresh ET in the protocol with GnRH antagonists and coryphollitropin alfa is associated with the additional administration of high doses of r-FSH, furthermore the effectiveness of treatment remains extremely low. Reduced ovarian reserve is an equally important factor affecting the effectiveness of IVF programs in addition to the woman{\textquoteright}s age.",

keywords = "Advanced maternal age, Coripollitropin alfa, Diminished ovarian reserve, Infertility, IVF",

author = "Yakovlev, {P. P.} and Kogan, {I. Yu} and Gzgzyan, {A. M.} and Andreeva, {N. Yu}",

year = "2019",

doi = "10.17116/repro20192505192",

language = "English",

volume = "25",

pages = "92--99",

journal = "ПРОБЛЕМЫ РЕПРОДУКЦИИ",

issn = "1025-7217",

publisher = "Медиа Сфера",

number = "5",

}

RIS

TY - JOUR

T1 - Corifollitropin alfa for ovarian stimulation in in vitro fertilization in women of advanced maternal age

AU - Yakovlev, P. P.

AU - Kogan, I. Yu

AU - Gzgzyan, A. M.

AU - Andreeva, N. Yu

PY - 2019

Y1 - 2019

N2 - The purpose of the study is to compare the effectiveness of IVF protocols with the use of corinollitropin alfa in women of advanced maternal age, depending on the ovarian reserve. Material and methods. Retrospective trial of infertile women (n=88) undergoing a single IVF/ICSI cycle with corifollitropin alfa. Depending on the age and state of the ovarian reserve, 3 groups of patients are formed. Group I (n=24) consisted of 37—42 years old women with a low ovarian reserve; group II (n=25) included patients of the same age with a normal ovarian reserve; the comparison group III (n=39) was formed from women 28—36 years with a normal ovarian reserve. Embryo transfer was performed in a fresh IVF cycle using GnRH antagonists protocols. Results. The duration of additional stimulation (from the 8th day of controlled ovarian stimulation) in I group was 6 (1—9), in II 3 (1—8) and in III 2 (1—4) days (pI—III = 0.016; pII—-III =0.171). The total dose of additional stimulation of r-FSH in I group was 1687 (275—2650), in II 675 (200—1950) and in III 450 (225—750) IU, (pI—III = 0.005; pII—III = 0.118). The dose of gonadotropins per 1 oocyte in group I was 1433 (748—2375), in II — 813 (506—900) and in III — 321 (192—386) IU (pI—III/pII—III <0.001). Percentage of mature oocytes (p=0.987) and fertilization rate (p=0.703) did not differ among groups. The frequency of biochemical pregnancy on ET in groups I, II, and III was 6.25, 25.5 and 36.4%, respectively (pI—III =0.037; pII—III = 0.548). The frequency of clinical pregnancies on ET in group I was 6.25%, in group II 17.6% and in group III 36.4% (pI—III = 0.037; pII—III =0.297). Conclusion. The use of fresh ET in the protocol with GnRH antagonists and coryphollitropin alfa is associated with the additional administration of high doses of r-FSH, furthermore the effectiveness of treatment remains extremely low. Reduced ovarian reserve is an equally important factor affecting the effectiveness of IVF programs in addition to the woman’s age.

AB - The purpose of the study is to compare the effectiveness of IVF protocols with the use of corinollitropin alfa in women of advanced maternal age, depending on the ovarian reserve. Material and methods. Retrospective trial of infertile women (n=88) undergoing a single IVF/ICSI cycle with corifollitropin alfa. Depending on the age and state of the ovarian reserve, 3 groups of patients are formed. Group I (n=24) consisted of 37—42 years old women with a low ovarian reserve; group II (n=25) included patients of the same age with a normal ovarian reserve; the comparison group III (n=39) was formed from women 28—36 years with a normal ovarian reserve. Embryo transfer was performed in a fresh IVF cycle using GnRH antagonists protocols. Results. The duration of additional stimulation (from the 8th day of controlled ovarian stimulation) in I group was 6 (1—9), in II 3 (1—8) and in III 2 (1—4) days (pI—III = 0.016; pII—-III =0.171). The total dose of additional stimulation of r-FSH in I group was 1687 (275—2650), in II 675 (200—1950) and in III 450 (225—750) IU, (pI—III = 0.005; pII—III = 0.118). The dose of gonadotropins per 1 oocyte in group I was 1433 (748—2375), in II — 813 (506—900) and in III — 321 (192—386) IU (pI—III/pII—III <0.001). Percentage of mature oocytes (p=0.987) and fertilization rate (p=0.703) did not differ among groups. The frequency of biochemical pregnancy on ET in groups I, II, and III was 6.25, 25.5 and 36.4%, respectively (pI—III =0.037; pII—III = 0.548). The frequency of clinical pregnancies on ET in group I was 6.25%, in group II 17.6% and in group III 36.4% (pI—III = 0.037; pII—III =0.297). Conclusion. The use of fresh ET in the protocol with GnRH antagonists and coryphollitropin alfa is associated with the additional administration of high doses of r-FSH, furthermore the effectiveness of treatment remains extremely low. Reduced ovarian reserve is an equally important factor affecting the effectiveness of IVF programs in addition to the woman’s age.

KW - Advanced maternal age

KW - Coripollitropin alfa

KW - Diminished ovarian reserve

KW - Infertility

KW - IVF

UR - http://www.scopus.com/inward/record.url?scp=85077033341&partnerID=8YFLogxK

U2 - 10.17116/repro20192505192

DO - 10.17116/repro20192505192

M3 - Article

AN - SCOPUS:85077033341

VL - 25

SP - 92

EP - 99

JO - ПРОБЛЕМЫ РЕПРОДУКЦИИ

JF - ПРОБЛЕМЫ РЕПРОДУКЦИИ

SN - 1025-7217

IS - 5

ER -

ID: 76493610