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Coordination to Imidazole Ring Switches On Phosphorescence of Platinum Cyclometalated Complexes: The Route to Selective Labeling of Peptides and Proteins via Histidine Residues. / Solomatina, Anastasia I.; Chelushkin, Pavel S; Krupenya, Dmitrii V.; Podkorytov, Ivan S.; Artamonova, Tatiana O.; Sizov, Vladimir V.; Melnikov, Alexei S; Gurzhiy, Vladislav V.; Koshel, Elena I.; Shcheslavskiy, Vladislav; Tunik, Sergey P.

In: Bioconjugate Chemistry, Vol. 28, No. 2, 2016, p. 426–437.

Research output: Contribution to journal › Article

Harvard

Solomatina, AI, Chelushkin, PS, Krupenya, DV, Podkorytov, IS, Artamonova, TO, Sizov, VV, Melnikov, AS, Gurzhiy, VV, Koshel, EI, Shcheslavskiy, V & Tunik, SP 2016, 'Coordination to Imidazole Ring Switches On Phosphorescence of Platinum Cyclometalated Complexes: The Route to Selective Labeling of Peptides and Proteins via Histidine Residues', Bioconjugate Chemistry, vol. 28, no. 2, pp. 426–437. https://doi.org/10.1021/acs.bioconjchem.6b00598

APA

Solomatina, A. I., Chelushkin, P. S., Krupenya, D. V., Podkorytov, I. S., Artamonova, T. O., Sizov, V. V., Melnikov, A. S., Gurzhiy, V. V., Koshel, E. I., Shcheslavskiy, V., & Tunik, S. P. (2016). Coordination to Imidazole Ring Switches On Phosphorescence of Platinum Cyclometalated Complexes: The Route to Selective Labeling of Peptides and Proteins via Histidine Residues. Bioconjugate Chemistry, 28(2), 426–437. https://doi.org/10.1021/acs.bioconjchem.6b00598

Vancouver

Solomatina AI, Chelushkin PS, Krupenya DV, Podkorytov IS, Artamonova TO, Sizov VV et al. Coordination to Imidazole Ring Switches On Phosphorescence of Platinum Cyclometalated Complexes: The Route to Selective Labeling of Peptides and Proteins via Histidine Residues. Bioconjugate Chemistry. 2016;28(2):426–437. https://doi.org/10.1021/acs.bioconjchem.6b00598

Author

Solomatina, Anastasia I. ; Chelushkin, Pavel S ; Krupenya, Dmitrii V. ; Podkorytov, Ivan S. ; Artamonova, Tatiana O. ; Sizov, Vladimir V. ; Melnikov, Alexei S ; Gurzhiy, Vladislav V. ; Koshel, Elena I. ; Shcheslavskiy, Vladislav ; Tunik, Sergey P. / Coordination to Imidazole Ring Switches On Phosphorescence of Platinum Cyclometalated Complexes: The Route to Selective Labeling of Peptides and Proteins via Histidine Residues. In: Bioconjugate Chemistry. 2016 ; Vol. 28, No. 2. pp. 426–437.

BibTeX

@article{a2060a79d02d45e3a3e97fcb2b5e1daa,
title = "Coordination to Imidazole Ring Switches On Phosphorescence of Platinum Cyclometalated Complexes: The Route to Selective Labeling of Peptides and Proteins via Histidine Residues",
abstract = "In this study we have shown that substitution of chloride ligand for imidazole (Im) ring in cyclometalated platinum complex, Pt(phpy)(PPh3)Cl (1; phpy = 2-phenylpyridine; PPh3 = triphenylphosphine), which is non-emissive in solution, switches on phosphorescence of the resulting compound. Crystallographic and NMR spectroscopic studies of the substitution product showed that the luminescence ignition is a result of Im coordination to give the [Pt(phpy)(Im)(PPh3)]Cl complex. The other imidazole-containing biomolecules such as histidine and histidine-containing peptides and proteins also trigger luminescence of the substitution products. The complex 1 proved to be highly selective towards the imidazole ring coordination that allows site-specific labelling of peptides and proteins with 1 using the route, which is orthogonal to the common bioconjugation schemes via lysine, aspartic/glutamic acids or cysteine and does not require any preliminary modification of a biomolecule. The utility of this approach was demonst",
author = "Solomatina, {Anastasia I.} and Chelushkin, {Pavel S} and Krupenya, {Dmitrii V.} and Podkorytov, {Ivan S.} and Artamonova, {Tatiana O.} and Sizov, {Vladimir V.} and Melnikov, {Alexei S} and Gurzhiy, {Vladislav V.} and Koshel, {Elena I.} and Vladislav Shcheslavskiy and Tunik, {Sergey P}",
year = "2016",
doi = "10.1021/acs.bioconjchem.6b00598",
language = "English",
volume = "28",
pages = "426–437",
journal = "Bioconjugate Chemistry",
issn = "1043-1802",
publisher = "American Chemical Society",
number = "2",

}

RIS

TY - JOUR

T1 - Coordination to Imidazole Ring Switches On Phosphorescence of Platinum Cyclometalated Complexes: The Route to Selective Labeling of Peptides and Proteins via Histidine Residues

AU - Solomatina, Anastasia I.

AU - Chelushkin, Pavel S

AU - Krupenya, Dmitrii V.

AU - Podkorytov, Ivan S.

AU - Artamonova, Tatiana O.

AU - Sizov, Vladimir V.

AU - Melnikov, Alexei S

AU - Gurzhiy, Vladislav V.

AU - Koshel, Elena I.

AU - Shcheslavskiy, Vladislav

AU - Tunik, Sergey P

PY - 2016

Y1 - 2016

N2 - In this study we have shown that substitution of chloride ligand for imidazole (Im) ring in cyclometalated platinum complex, Pt(phpy)(PPh3)Cl (1; phpy = 2-phenylpyridine; PPh3 = triphenylphosphine), which is non-emissive in solution, switches on phosphorescence of the resulting compound. Crystallographic and NMR spectroscopic studies of the substitution product showed that the luminescence ignition is a result of Im coordination to give the [Pt(phpy)(Im)(PPh3)]Cl complex. The other imidazole-containing biomolecules such as histidine and histidine-containing peptides and proteins also trigger luminescence of the substitution products. The complex 1 proved to be highly selective towards the imidazole ring coordination that allows site-specific labelling of peptides and proteins with 1 using the route, which is orthogonal to the common bioconjugation schemes via lysine, aspartic/glutamic acids or cysteine and does not require any preliminary modification of a biomolecule. The utility of this approach was demonst

AB - In this study we have shown that substitution of chloride ligand for imidazole (Im) ring in cyclometalated platinum complex, Pt(phpy)(PPh3)Cl (1; phpy = 2-phenylpyridine; PPh3 = triphenylphosphine), which is non-emissive in solution, switches on phosphorescence of the resulting compound. Crystallographic and NMR spectroscopic studies of the substitution product showed that the luminescence ignition is a result of Im coordination to give the [Pt(phpy)(Im)(PPh3)]Cl complex. The other imidazole-containing biomolecules such as histidine and histidine-containing peptides and proteins also trigger luminescence of the substitution products. The complex 1 proved to be highly selective towards the imidazole ring coordination that allows site-specific labelling of peptides and proteins with 1 using the route, which is orthogonal to the common bioconjugation schemes via lysine, aspartic/glutamic acids or cysteine and does not require any preliminary modification of a biomolecule. The utility of this approach was demonst

U2 - 10.1021/acs.bioconjchem.6b00598

DO - 10.1021/acs.bioconjchem.6b00598

M3 - Article

VL - 28

SP - 426

EP - 437

JO - Bioconjugate Chemistry

JF - Bioconjugate Chemistry

SN - 1043-1802

IS - 2

ER -

ID: 7616623