Research output: Contribution to journal › Article › peer-review
Conformational stabilization of isatin Schiff bases -biologically active chemical probes. / Smirnov, Andrey S.; Nikolaev, Dmitriy N.; Gurzhiy, Vlad V.; Smirnov, Sergey N.; Suslonov, Vitaliy S.; Garabadzhiu, Alexander V.; Davidovich, Pavel B.
In: RSC Advances, Vol. 7, No. 17, 2017, p. 10070-10073.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Conformational stabilization of isatin Schiff bases -biologically active chemical probes
AU - Smirnov, Andrey S.
AU - Nikolaev, Dmitriy N.
AU - Gurzhiy, Vlad V.
AU - Smirnov, Sergey N.
AU - Suslonov, Vitaliy S.
AU - Garabadzhiu, Alexander V.
AU - Davidovich, Pavel B.
PY - 2017
Y1 - 2017
N2 - Isatin Schiff base derivatives have a wide range of biological effects. Unfortunately, these compounds possess a serious topological shortcoming: the conformational E Z interconversion. Two ways of conformation stabilization are reported here: complexation with metals that stabilize the E-conformer and substitution in the 4th position of the isatin core stabilizing the Z-form.
AB - Isatin Schiff base derivatives have a wide range of biological effects. Unfortunately, these compounds possess a serious topological shortcoming: the conformational E Z interconversion. Two ways of conformation stabilization are reported here: complexation with metals that stabilize the E-conformer and substitution in the 4th position of the isatin core stabilizing the Z-form.
UR - http://www.scopus.com/inward/record.url?scp=85011982426&partnerID=8YFLogxK
U2 - 10.1039/c6ra26779c
DO - 10.1039/c6ra26779c
M3 - Article
AN - SCOPUS:85011982426
VL - 7
SP - 10070
EP - 10073
JO - RSC Advances
JF - RSC Advances
SN - 2046-2069
IS - 17
ER -
ID: 9151661