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Computational search for potential posttranslational modification sites in human RNA polymerase III subunits. / Nikitina, T. V.; Tishchenko, L. I.

In: Molecular Biology, Vol. 39, No. 3, 01.05.2005, p. 387-393.

Research output: Contribution to journal › Article › peer-review

Harvard

Nikitina, TV & Tishchenko, LI 2005, 'Computational search for potential posttranslational modification sites in human RNA polymerase III subunits', Molecular Biology, vol. 39, no. 3, pp. 387-393. https://doi.org/10.1007/s11008-005-0053-5

APA

Nikitina, T. V., & Tishchenko, L. I. (2005). Computational search for potential posttranslational modification sites in human RNA polymerase III subunits. Molecular Biology, 39(3), 387-393. https://doi.org/10.1007/s11008-005-0053-5

Vancouver

Nikitina TV, Tishchenko LI. Computational search for potential posttranslational modification sites in human RNA polymerase III subunits. Molecular Biology. 2005 May 1;39(3):387-393. https://doi.org/10.1007/s11008-005-0053-5

Author

Nikitina, T. V. ; Tishchenko, L. I. / Computational search for potential posttranslational modification sites in human RNA polymerase III subunits. In: Molecular Biology. 2005 ; Vol. 39, No. 3. pp. 387-393.

BibTeX

@article{a719034792704871b95efc9b421459e8,
title = "Computational search for potential posttranslational modification sites in human RNA polymerase III subunits",
abstract = "The transcription of small stable nontranslated RNA genes (class III genes), directed by RNA polymerase III, is strictly regulated in accordance with the physiological state of the cell (growth rate, cell cycle stage, apoptosis, etc.) Posttranslational modifications of RNA polymerase may play an important role in class III gene transcription regulation. Using computational programs that search for potential posttranslational modification sites in proteins (MotifScan, NetPhos 2.0, and Yin-Yang 1.2), possible sites of phosphorylation were identified in all 17 subunits of human RNA polymerase III, and possible sites of reciprocal phosphorylation and glycosylation (the {"}yin-yang{"} sites) were identified in 13 subunits. Among them, 17 phosphorylation sites in seven subunits proved to be conserved in H. sapiens, Saccharomyces cerevisiae, and Schzosaccharomyces pombe, including two yin-yang sites in two subunits. The data obtained can be used for experimental identification of RNA polymerase III modification sites in vivo in cells that are in different physiological states.",
keywords = "Class III genes, Computational search, Glycosylation, Human RNA polymerase III, Phosphorylation, Protein modification sites, Transcription regulation, Yin-yang sites",
author = "Nikitina, {T. V.} and Tishchenko, {L. I.}",
year = "2005",
month = may,
day = "1",
doi = "10.1007/s11008-005-0053-5",
language = "English",
volume = "39",
pages = "387--393",
journal = "Molecular Biology",
issn = "0026-8933",
publisher = "Pleiades Publishing",
number = "3",

}

RIS

TY - JOUR

T1 - Computational search for potential posttranslational modification sites in human RNA polymerase III subunits

AU - Nikitina, T. V.

AU - Tishchenko, L. I.

PY - 2005/5/1

Y1 - 2005/5/1

N2 - The transcription of small stable nontranslated RNA genes (class III genes), directed by RNA polymerase III, is strictly regulated in accordance with the physiological state of the cell (growth rate, cell cycle stage, apoptosis, etc.) Posttranslational modifications of RNA polymerase may play an important role in class III gene transcription regulation. Using computational programs that search for potential posttranslational modification sites in proteins (MotifScan, NetPhos 2.0, and Yin-Yang 1.2), possible sites of phosphorylation were identified in all 17 subunits of human RNA polymerase III, and possible sites of reciprocal phosphorylation and glycosylation (the "yin-yang" sites) were identified in 13 subunits. Among them, 17 phosphorylation sites in seven subunits proved to be conserved in H. sapiens, Saccharomyces cerevisiae, and Schzosaccharomyces pombe, including two yin-yang sites in two subunits. The data obtained can be used for experimental identification of RNA polymerase III modification sites in vivo in cells that are in different physiological states.

AB - The transcription of small stable nontranslated RNA genes (class III genes), directed by RNA polymerase III, is strictly regulated in accordance with the physiological state of the cell (growth rate, cell cycle stage, apoptosis, etc.) Posttranslational modifications of RNA polymerase may play an important role in class III gene transcription regulation. Using computational programs that search for potential posttranslational modification sites in proteins (MotifScan, NetPhos 2.0, and Yin-Yang 1.2), possible sites of phosphorylation were identified in all 17 subunits of human RNA polymerase III, and possible sites of reciprocal phosphorylation and glycosylation (the "yin-yang" sites) were identified in 13 subunits. Among them, 17 phosphorylation sites in seven subunits proved to be conserved in H. sapiens, Saccharomyces cerevisiae, and Schzosaccharomyces pombe, including two yin-yang sites in two subunits. The data obtained can be used for experimental identification of RNA polymerase III modification sites in vivo in cells that are in different physiological states.

KW - Class III genes

KW - Computational search

KW - Glycosylation

KW - Human RNA polymerase III

KW - Phosphorylation

KW - Protein modification sites

KW - Transcription regulation

KW - Yin-yang sites

UR - http://www.scopus.com/inward/record.url?scp=21544468568&partnerID=8YFLogxK

U2 - 10.1007/s11008-005-0053-5

DO - 10.1007/s11008-005-0053-5

M3 - Article

AN - SCOPUS:21544468568

VL - 39

SP - 387

EP - 393

JO - Molecular Biology

JF - Molecular Biology

SN - 0026-8933

IS - 3

ER -

ID: 53110806