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Computational search for potential post-translational modification sites in human RNA polymerase III subunits. / Nikitina, T. V.; Tishchenko, L. I.

In: Molekulyarnaya Biologiya, Vol. 39, No. 3, 01.12.2005, p. 437-444.

Research output: Contribution to journal › Article › peer-review

Harvard

Nikitina, TV & Tishchenko, LI 2005, 'Computational search for potential post-translational modification sites in human RNA polymerase III subunits', Molekulyarnaya Biologiya, vol. 39, no. 3, pp. 437-444.

APA

Nikitina, T. V., & Tishchenko, L. I. (2005). Computational search for potential post-translational modification sites in human RNA polymerase III subunits. Molekulyarnaya Biologiya, 39(3), 437-444.

Vancouver

Nikitina TV, Tishchenko LI. Computational search for potential post-translational modification sites in human RNA polymerase III subunits. Molekulyarnaya Biologiya. 2005 Dec 1;39(3):437-444.

Author

Nikitina, T. V. ; Tishchenko, L. I. / Computational search for potential post-translational modification sites in human RNA polymerase III subunits. In: Molekulyarnaya Biologiya. 2005 ; Vol. 39, No. 3. pp. 437-444.

BibTeX

@article{9c9506ab0ade4dbfb68468eddf2cf15a,
title = "Computational search for potential post-translational modification sites in human RNA polymerase III subunits",
abstract = "The transcription of small stable non-translated RNA genes (class III genes), directed by RNA polymerase III, is strictly regulated in accordance to physiological state of the cell (growth rate, cell cycle stage, apoptosis, etc.) Post-translational modifications of the polymerase may play the important role in class III gene transcription regulation. Using computational programs searching for potential post-translational modifications sites in proteins (MotifScan, NetPhos 2.0, and Yin-Yan 1.2), possible sites of phosphorylation were identified in all 17 subunits of human RNA polymerase III, and possible sites of reciprocal phosphorylation and glycosilation ({"}yin-yan{"} sites) - in 13 subunits. Among the identified sites - 17 sites of phosphorylation in seven subunits are conservative in human, Saccharomyces cerevisiae and Schizosaccharomyces pombe, including two {"}yin-yan{"} sites in two subunits. The data obtained can be used for experimental identification of RNA polymerase III modification sites in vivo in cells being in different physiological states.",
author = "Nikitina, {T. V.} and Tishchenko, {L. I.}",
year = "2005",
month = dec,
day = "1",
language = "English",
volume = "39",
pages = "437--444",
journal = "МОЛЕКУЛЯРНАЯ БИОЛОГИЯ",
issn = "0026-8984",
publisher = "Российская академия наук",
number = "3",

}

RIS

TY - JOUR

T1 - Computational search for potential post-translational modification sites in human RNA polymerase III subunits

AU - Nikitina, T. V.

AU - Tishchenko, L. I.

PY - 2005/12/1

Y1 - 2005/12/1

N2 - The transcription of small stable non-translated RNA genes (class III genes), directed by RNA polymerase III, is strictly regulated in accordance to physiological state of the cell (growth rate, cell cycle stage, apoptosis, etc.) Post-translational modifications of the polymerase may play the important role in class III gene transcription regulation. Using computational programs searching for potential post-translational modifications sites in proteins (MotifScan, NetPhos 2.0, and Yin-Yan 1.2), possible sites of phosphorylation were identified in all 17 subunits of human RNA polymerase III, and possible sites of reciprocal phosphorylation and glycosilation ("yin-yan" sites) - in 13 subunits. Among the identified sites - 17 sites of phosphorylation in seven subunits are conservative in human, Saccharomyces cerevisiae and Schizosaccharomyces pombe, including two "yin-yan" sites in two subunits. The data obtained can be used for experimental identification of RNA polymerase III modification sites in vivo in cells being in different physiological states.

AB - The transcription of small stable non-translated RNA genes (class III genes), directed by RNA polymerase III, is strictly regulated in accordance to physiological state of the cell (growth rate, cell cycle stage, apoptosis, etc.) Post-translational modifications of the polymerase may play the important role in class III gene transcription regulation. Using computational programs searching for potential post-translational modifications sites in proteins (MotifScan, NetPhos 2.0, and Yin-Yan 1.2), possible sites of phosphorylation were identified in all 17 subunits of human RNA polymerase III, and possible sites of reciprocal phosphorylation and glycosilation ("yin-yan" sites) - in 13 subunits. Among the identified sites - 17 sites of phosphorylation in seven subunits are conservative in human, Saccharomyces cerevisiae and Schizosaccharomyces pombe, including two "yin-yan" sites in two subunits. The data obtained can be used for experimental identification of RNA polymerase III modification sites in vivo in cells being in different physiological states.

UR - http://www.scopus.com/inward/record.url?scp=22944438106&partnerID=8YFLogxK

M3 - Article

C2 - 15981573

AN - SCOPUS:22944438106

VL - 39

SP - 437

EP - 444

JO - МОЛЕКУЛЯРНАЯ БИОЛОГИЯ

JF - МОЛЕКУЛЯРНАЯ БИОЛОГИЯ

SN - 0026-8984

IS - 3

ER -

ID: 53110669