Composite Biomaterials Based on Poly (L-Lactic Acid ) and Functionalized Cellulose Nanocrystals

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Composite Biomaterials Based on Poly (L-Lactic Acid ) and Functionalized Cellulose Nanocrystals. / Stepanova, Mariia ; Averianov, Ilia ; Solomakha, Olga ; Zabolotnykh, Natalia ; Gofman, Iosif ; Serdobintsev, Mikhail ; Vinogradova, Tatiana ; Korzhikov-Vlakh, Viktor ; Korzhikova-Vlakh, Evgenia .

In: Journal of Renewable Materials, Vol. 8, No. 4, 2020, p. 383-395.

Research output: Contribution to journal › Article › peer-review

Author

Stepanova, Mariia ; Averianov, Ilia ; Solomakha, Olga ; Zabolotnykh, Natalia ; Gofman, Iosif ; Serdobintsev, Mikhail ; Vinogradova, Tatiana ; Korzhikov-Vlakh, Viktor ; Korzhikova-Vlakh, Evgenia . / Composite Biomaterials Based on Poly (L-Lactic Acid ) and Functionalized Cellulose Nanocrystals. In: Journal of Renewable Materials. 2020 ; Vol. 8, No. 4. pp. 383-395.

BibTeX

@article{2980ee34dd3345c9bb432b81452aa081,

title = "Composite Biomaterials Based on Poly (L-Lactic Acid ) and Functionalized Cellulose Nanocrystals",

abstract = "The biocompositefilms were prepared from poly(L-lactic acid) and cel-lulose nanocrystals. To improve interfacial compatibility of hydrophilic cellulosenanocrystals with hydrophobic matrix polymer as well as to provide the osteocon-ductive properties, cellulose was functionalized with poly(glutamic acid). Themodified cellulose nanocrystals were better distributed and less aggregated withinthe matrix, which was testified by scanning electron, optical and polarized lightmicroscopy. According to mechanical tests, compositesfilled with nanocrystalsmodified with PGlu demonstrated higher values of Young{\textquoteright}s modulus, elongationat break and tensile strength. Incubation of composite materials in model buffersolutions for 30 weeks followed with staining of Ca2+deposits with AlizarinRed S assay testified better mineralization of materials containing PGlu-modifiedcellulose nanocrystals asfiller. As the result of in vivo experiment, the developedcomposite materials showed less level of inflammation in comparison with purepolymer matrix and compositesfilled with non-functionalized cellulosenanocrystals.Keywords:Bio",

keywords = "Biomaterials, polymer composites, biodegradable and biocompatiblepolymers, poly(L-lactic acid), Cellulose nanocrystals, modification, Modification, Poly(L-lactic acid), Polymer composites, Biodegradable and biocompatible polymers",

author = "Mariia Stepanova and Ilia Averianov and Olga Solomakha and Natalia Zabolotnykh and Iosif Gofman and Mikhail Serdobintsev and Tatiana Vinogradova and Viktor Korzhikov-Vlakh and Evgenia Korzhikova-Vlakh",

year = "2020",

doi = "10.32604/jrm.2020.09206",

language = "English",

volume = "8",

pages = "383--395",

journal = "Journal of Renewable Materials",

issn = "2164-6325",

publisher = "Scrivener Publishing",

number = "4",

}

RIS

TY - JOUR

T1 - Composite Biomaterials Based on Poly (L-Lactic Acid ) and Functionalized Cellulose Nanocrystals

AU - Stepanova, Mariia

AU - Averianov, Ilia

AU - Solomakha, Olga

AU - Zabolotnykh, Natalia

AU - Gofman, Iosif

AU - Serdobintsev, Mikhail

AU - Vinogradova, Tatiana

AU - Korzhikov-Vlakh, Viktor

AU - Korzhikova-Vlakh, Evgenia

PY - 2020

Y1 - 2020

N2 - The biocompositefilms were prepared from poly(L-lactic acid) and cel-lulose nanocrystals. To improve interfacial compatibility of hydrophilic cellulosenanocrystals with hydrophobic matrix polymer as well as to provide the osteocon-ductive properties, cellulose was functionalized with poly(glutamic acid). Themodified cellulose nanocrystals were better distributed and less aggregated withinthe matrix, which was testified by scanning electron, optical and polarized lightmicroscopy. According to mechanical tests, compositesfilled with nanocrystalsmodified with PGlu demonstrated higher values of Young’s modulus, elongationat break and tensile strength. Incubation of composite materials in model buffersolutions for 30 weeks followed with staining of Ca2+deposits with AlizarinRed S assay testified better mineralization of materials containing PGlu-modifiedcellulose nanocrystals asfiller. As the result of in vivo experiment, the developedcomposite materials showed less level of inflammation in comparison with purepolymer matrix and compositesfilled with non-functionalized cellulosenanocrystals.Keywords:Bio

AB - The biocompositefilms were prepared from poly(L-lactic acid) and cel-lulose nanocrystals. To improve interfacial compatibility of hydrophilic cellulosenanocrystals with hydrophobic matrix polymer as well as to provide the osteocon-ductive properties, cellulose was functionalized with poly(glutamic acid). Themodified cellulose nanocrystals were better distributed and less aggregated withinthe matrix, which was testified by scanning electron, optical and polarized lightmicroscopy. According to mechanical tests, compositesfilled with nanocrystalsmodified with PGlu demonstrated higher values of Young’s modulus, elongationat break and tensile strength. Incubation of composite materials in model buffersolutions for 30 weeks followed with staining of Ca2+deposits with AlizarinRed S assay testified better mineralization of materials containing PGlu-modifiedcellulose nanocrystals asfiller. As the result of in vivo experiment, the developedcomposite materials showed less level of inflammation in comparison with purepolymer matrix and compositesfilled with non-functionalized cellulosenanocrystals.Keywords:Bio

KW - Biomaterials

KW - polymer composites

KW - biodegradable and biocompatiblepolymers

KW - poly(L-lactic acid)

KW - Cellulose nanocrystals

KW - modification

KW - Modification

KW - Poly(L-lactic acid)

KW - Polymer composites

KW - Biodegradable and biocompatible polymers

UR - http://www.scopus.com/inward/record.url?scp=85084477747&partnerID=8YFLogxK

U2 - 10.32604/jrm.2020.09206

DO - 10.32604/jrm.2020.09206

M3 - Article

VL - 8

SP - 383

EP - 395

JO - Journal of Renewable Materials

JF - Journal of Renewable Materials

SN - 2164-6325

IS - 4

ER -

ID: 51734969