Ferroglobus placidus belongs to the order Archaeoglobales within the archaeal phylum Euryar-chaeota. Strain AEDII12DO is the type strain of the species and was isolated from a shallow marine hydrothermal system at Vulcano, Italy. It is a hyperthermophilic, anaerobic chemoli-thoautotroph, but it can also use a variety of aromatic compounds as electron donors. Here we describe the features of this organism together with the complete genome sequence and anno-tation. The 2,196,266 bp genome with its 2,567 protein-coding and 55 RNA genes was se-quenced as part of a DOE Joint Genome Institute Laboratory Sequencing Program (LSP) project.